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Patent # Description
US-9,493,834 Method for detecting a panel of biomarkers
The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related...
US-9,493,833 Methods for preventing induced synthesis of proteasomes in human cells
Methods and compositions for inhibiting Nrf1 activity are provided for enhancing apoptosis in mammalian cells. Apoptosis is enhanced in mammalian cells by...
US-9,493,832 Methods of detecting sepsis
Methods of detecting sepsis in a sample from a patient are provided. Methods of detecting changes in expression of one or more microRNAs associated with sepsis...
US-9,493,831 Methods of fetal abnormality detection
Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are...
US-9,493,830 Reagents, methods, and libraries for bead-based sequencing
The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded...
US-9,493,829 Method of DNA sequencing by polymerisation
Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule...
US-9,493,828 Methods for determining fraction of fetal nucleic acids in maternal samples
The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and...
US-9,493,827 Determination of in vivo DNA double-strand break localization and application thereof
The present invention relates to a method for determining the in vivo localization of double-strand breaks in a host cell, comprising incubating a host cell...
US-9,493,826 Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also...
US-9,493,825 Materials and methods for profiling microRNAs
The present invention provides materials and methods for detecting, quantifying, and/or high-throughput-profiling microRNAs. Advantageously, the present...
US-9,493,824 Universal reference dye for quantitative amplification
Universal reference dye mixtures for quantitative amplification, and uses thereof, are provided.
US-9,493,823 Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking...
US-9,493,822 Devices and methods for microarray selection
The present invention relates to a device for the specific selection of target molecules, wherein immobilized capture molecules can be organized in a microarray...
US-9,493,821 DNA library, preparation method thereof, and device for detecting SNPs
A DNA library, and a preparing method thereof, a method of determining DNA sequence information, an apparatus and a kit for detecting SNPs, and a method for...
US-9,493,820 Strategies for high throughput identification and detection of polymorphisms
The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more...
US-9,493,819 Sensor device and method for label-free detecting of nucleic acid sequences
A sensor device, which is adapted for detecting target molecules having a target nucleic acid sequence, comprises an optical whispering gallery mode (WGM)...
US-9,493,818 Methods and compositions for detection of small RNAS
Currently, the circularization of small RNAs is broadly regarded as an obstacle in ligation-related assays and explicitly avoided while short lengths of linear...
US-9,493,817 Decomposition method and decomposition apparatus for nucleic acid polymer
A method for decomposing a target nucleic acid polymer, comprising: bonding a probe nucleic acid polymer and a microparticle to form a probe nucleic acid...
US-9,493,816 Composite liquid cells
A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a...
US-9,493,815 Microarray based sample detection system
A microarray assembly for detection of a target molecule is disclosed. The microarray assemblies comprise an array chamber having a microarray located therein...
US-9,493,814 Flavin-binding glucose dehydrogenase having improved substrate specificity
A flavin-binding glucose dehydrogenase having high substrate specificity for D-glucose and decreased reactivity to D-xylose and/or maltose. More specifically, a...
US-9,493,813 Modulation of phosphatidylinositol-5-phosphate-4-kinase activity
The invention features methods for identifying compounds that modulate the activity of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K). Inhibitors of PI5P4K...
US-9,493,812 Method for detecting a target analyte that exhibits protease enzyme activity
The described invention provides a method for detecting a target analyte that exhibits protease enzyme activity. The described method includes contacting a...
US-9,493,811 Method of neonatal serological diagnosis
The present invention provides a method for determining the amino acid polymorphisms of heavy gamma chain of immunoglobulins G by a proteomic approach. This...
US-9,493,810 5-ALA for detection of brain tumors
The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition...
US-9,493,809 Method for specifically labeling living bacteria
The present invention concerns a method for labeling specifically living bacteria of a given category in a sample, the method including: a) incubating said...
US-9,493,808 Reagent composition for biosensor and biosensor having the same
This invention discloses a reagent composition for a biosensor having high sensitivity which is capable of improving analysis linearity of an analyte such as...
US-9,493,807 Foldover sensors and methods for making and using them
The invention disclosed herein includes sensors having three dimensional configurations that allow expansive "360.degree." sensing (i.e. sensing analyte from...
US-9,493,806 Enzymatic biosensing systems
Biosensors and methods of producing biosensors for use in detecting one or more analytes in a solution are disclosed herein.
US-9,493,805 Enzymatic biosensors with enhanced activity retention for detection of organic compounds
Enzymatic biosensors and methods of producing distal tips for biosensor transducers for use in detecting one or more analytes selected from organic compounds...
US-9,493,804 Agents and methods for the expression and secretion of peptides and proteins
The present invention relates to a nucleic acid molecule for recombinant expression and secretion of a peptide or protein of interest comprising a hemolysin A...
US-9,493,803 Artificial introns
The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a...
US-9,493,802 Use of glycohydrolase 61 protein variants with improved thermostability for processing cellulose
The invention provides recombinant GH61 proteins obtained from Myceliophtora thermophila, and nucleic acids that encode such proteins. The invention also...
US-9,493,801 Compositions and methods of producing methionine
Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous...
US-9,493,800 Acyl amino acids
Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered...
US-9,493,799 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using...
US-9,493,798 Process for producing unsaturated fatty acid-containing oils
An edible oil obtained by culturing a microorganism belong to the genus Mortierella subgenus Mortierella in a medium containing a nitrogen source derived from...
US-9,493,797 Method and apparatus for accelerating biotechnical reaction and production
The present invention is related to a method of using an apparatus for biotechnical production. The method includes the receiving a flow of an amount of a raw...
US-9,493,796 Processing biomass
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use...
US-9,493,795 Metabolically enhanced cyanobacterial cell for the production of ethanol
A metabolically enhanced cyanobacterial cell for the production of ethanol is provided. The metabolically enhanced cyanobacterial cell for the production of...
US-9,493,794 Metabolically enhanced cyanobacterial cell for the production of ethanol
A metabolically enhanced cyanobacterial cell for the production of ethanol is provided. The metabolically enhanced cyanobacterial cell for the production of...
US-9,493,793 Compositions and methods for increased ethanol titer from biomass
The present application discloses the identification of novel I. orientalis ADH1, ADHa, and ADHb genes, and the production and characterization of genetically...
US-9,493,792 Process for production of yellow pigment from bacteria
The process for the production of the yellow pigment can include the steps of (a) culturing Bacillus sp. GSK07 bacteria; and (b) extracting the yellow pigment...
US-9,493,791 Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous...
US-9,493,790 Methods for producing multiple recombinant polypeptides in a filamentous fungal host cell
The present invention relates to methods for constructing a filamentous fungal strain for production of multiple recombinant polypeptides having biological...
US-9,493,789 Automated generation of genetically modified stem cells
The invention relates to a process for generation of genetically modified stem cells comprising the steps a) providing a cell sample in suspension comprising...
US-9,493,788 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such...
US-9,493,787 Powdery mildew resistance providing genes in Cucumis sativus
The present invention relates to powdery mildew resistance providing genes of the Cucumis family, and especially Cucumis sativus, wherein said resistance is...
US-9,493,786 Soybean plant and seed corresponding to transgenic event MON87712 comprising a B-box zinc finger protein 32,...
The present invention provides a transgenic soybean comprising event MONS87712 that expresses a B-box zinc-finger protein 32 (BBX32) and exhibits increased...
US-9,493,785 Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth...
Provided are isolated polynucleotides encoding a polypeptide at least 80% homologous to the amino acid sequence selected from the group consisting of SEQ ID...
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