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Patent # Description
US-9,493,583 Anionic polysaccharides functionalized by a hydrophobic acid derivative
A novel anionic polysaccharides functionalized by at least one hydrophobic acid derivative. These novel anionic polysaccharides including hydrophobic groups...
US-9,493,582 Alkylated cyclodextrin compositions and processes for preparing and using the same
The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the...
US-9,493,581 Process for the manufacture of viscose
A process for the manufacture of viscose comprises the steps of: a) providing a non-dissolving pulp as a raw material; b) steeping the pulp in caustic solution;...
US-9,493,580 Multivalent glycopeptide constructs and uses thereof
Glycopeptide conjugates comprising GM2 and/or Gb5 carbohydrate determinants, and methods of making and using such conjugates are disclosed. The immunogenicity...
US-9,493,579 Multivalent antibodies and uses therefor
The present application describes engineered antibodies, with three or more functional antigen binding sites, and uses, such as therapeutic applications, for...
US-9,493,578 Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
Immunoglobulin compositions that simultaneously co-engage antigens, where one of the antigens is bound bivalently and the other antigen is bound monovalently....
US-9,493,577 Human antigen binding proteins that bind .beta.-klotho, FGF receptors and complexes thereof
The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments,...
US-9,493,576 Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and...
US-9,493,575 Methods for manipulating phagocytosis mediated by CD47
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
US-9,493,574 Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may...
US-9,493,573 Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may...
US-9,493,572 GITR antibodies and methods of inducing or enhancing an immune response
The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of...
US-9,493,571 Compositions comprising RANK/RANKL antagonists and related compounds for treating pain
Disclosed herein are methods of treating pain using comprising RANK/RANKL antagonists.
US-9,493,570 Fixed dosage regimens for anti-type I interferon receptor (IFNAR) antibodies
The disclosure provides methods for treating a subject having a type I IFN-mediated disease or disorder comprising administration of a fixed does of an...
US-9,493,569 Structural isomers of sc(Fv)2
Structural isomers in sc(Fv)2 compositions of anti-human Mpl antibody and humanized anti-human Mpl antibody were separated, and the obtained structural isomers...
US-9,493,568 Anti-EGFR antibodies and antibody drug conjugates
The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said...
US-9,493,567 Methods of treating inflammatory and autoimmune diseases with natalizumab
Natalizumab is a safe and efficacious treatment for inflammatory and autoimmune diseases, such as multiple sclerosis, Crohn's Disease, and rheumatoid arthritis....
US-9,493,566 Antibodies to integrin AVB6 and use of same to treat cancer
The invention provides antibodies that specifically bind to integrin .alpha.v.beta.6. The antibodies are useful for treatment and diagnoses of various cancers...
US-9,493,565 Targeted binding agents against B7-H1
Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity...
US-9,493,564 CD86 antagonist multi-target binding proteins
This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an...
US-9,493,563 Production of T cell retargeting hetero-dimeric immunoglobulins
The present invention describes novel hetero-dimeric immunoglobulins or fragments thereof which bind to CD3 and a disease associated antigen. These...
US-9,493,562 Anti-Siglec-15 antibodies
Antibodies and antigen binding fragments that specifically binds to Siglec-15 are described herein. These antibodies or antigen binding fragments may have the...
US-9,493,561 Antibodies to Toso
The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such...
US-9,493,560 Dual variable domain immunoglobulins and uses thereof
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are...
US-9,493,559 Bacterial host strain expressing recombinant DsbC and having reduced Tsp activity
The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding DsbC...
US-9,493,558 Bacterial host strain comprising a mutant SPR gene and a wild-type TSP gene
The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell...
US-9,493,557 Chemokine binding polypeptides for treating autoimmunity and inflammation
Novel polypeptides comprising a chemokine-binding peptide and an Fc fragment are disclosed. The polypeptides are capable of binding to certain chemokines so as...
US-9,493,556 Actriia binding agents and uses thereof
The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIA and uses for same.
US-9,493,555 Modulation of synaptic maintenance
C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual...
US-9,493,554 Methods of treating retinal disorders with anti-apelin antibodies
This disclosure relates to apelin antigen-binding proteins and methods of using the apelin antigen-binding proteins. The antigen-binding protein may comprise an...
US-9,493,553 Anti-alpha-synuclein antibodies and methods of use
Provided herein are anti-human alpha-synuclein antibodies, including, for example, antibodies that bind to human alpha-synuclein which has a free N-terminal...
US-9,493,552 Therapeutic biologic for treatment of hepatocellular carcinoma
The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular...
US-9,493,551 Antibodies containing therapeutic TPO/EPO mimetic peptides
The present disclosure features therapeutic antibodies (e.g., TPO mimetic antibodies) and therapeutically-active fragments thereof as well as methods for...
US-9,493,550 Human anti-human influenza virus antibody
Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes...
US-9,493,549 Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted...
US-9,493,548 Immunoglobulin purification
The current invention reports a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an...
US-9,493,547 Binding proteins to the constant region of immunoglobulin G
The present invention provides polypeptides that bind to immunoglobulin G and methods for their use.
US-9,493,546 Fibronectin based scaffold domain proteins that bind to myostatin
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in...
US-9,493,545 Albumin variants and conjugates
Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a...
US-9,493,544 Von willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making...
US-9,493,543 Factor VIII fusion protein
The present invention relates to modified coagulation factors. In particular, the present invention relates to conjugated Factor VIII molecules fused to a...
US-9,493,542 Methods of using ERBB2 conjugate peptides
Compositions that inhibit or block the interaction between Erbin and ErbB2 and methods of their use are provided. Preferred compositions include peptides that...
US-9,493,541 Antibodies specific for sulfated sclerostin
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a. Also...
US-9,493,540 Ecdysone receptor/invertebrate retinoid X receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More...
US-9,493,539 Peptides associated with HLA-DR MHC class II molecules involved in autoimmune diseases
Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are...
US-9,493,538 Snares for pathogenic or infectious agents and uses related thereto
The present invention provides a snare molecules comprising an attachment moiety (which facilitates attachment of a receptor to a cell) and a receptor for a...
US-9,493,537 Compounds with reduced ring size for use in diagnosing and treating melanoma, including metastatic melanoma and...
The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in...
US-9,493,536 Growth hormone receptor antagonists
We disclose growth hormone fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of...
US-9,493,534 Long-acting oxyntomodulin variants and methods of producing same
This invention is directed to a chorionic gonadotrophin carboxy terminal peptide (CTP) modified dual GLP-1/glucagon receptor agonist, and methods of producing...
US-9,493,533 IL-15 mutants having antagonist activity
The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor...
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