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Patent # Description
US-9,493,532 Compositions for cancer therapy using mutant light molecules with increased affinity to receptors
Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These...
US-9,493,531 Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be...
US-9,493,530 FGF21 mutants comprising a mutation at position 98, 171 and/or 180
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant...
US-9,493,529 Robo1-Fc fusion protein and use thereof for treating tumours
The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in...
US-9,493,528 Microphthalmia-associated transcription factor-derived peptide and composition containing same
Provided are small peptide fragments derived from microphthalmia-associated transcription factor (MITF) and a method for preventing or treating melanoma using...
US-9,493,527 Compositions and methods for the delivery of nitric oxide
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise...
US-9,493,526 Compositions and methods for the delivery of oxygen
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H-NOX proteins...
US-9,493,525 AKT ligands and polynucleotides encoding AKT ligands
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate...
US-9,493,524 Methods for treatment of stroke or cerebrovascular accidents using an ET.sub.B receptor agonist
Methods of using an ET.sub.B receptor agonist, such as IRL-1620, for the treatment of stroke or cerebrovascular accidents are disclosed. The ET.sub.B receptor...
US-9,493,523 RNF8-FHA domain-modified protein and method of producing the same
Provided is an antigen-binding protein prepared merely by a method of in vitro selection using the RNF8-FHA domain, which has no intramolecular disulfide bond...
US-9,493,522 Discovery of candidate biomarkers of in vivo apoptosis by global profiling of caspase cleavage sites
The present invention relates to the discovery of novel biomarkers of in vivo apoptosis based on a large number of caspase-like cleavage sites. These biomarkers...
US-9,493,521 Fluorescent and colored proteins and methods for using them
The field of this invention relates to methods for combining genetic elements such that the activity of one of the elements provides a means for identifying,...
US-9,493,520 Fatty acid desaturases and elongases and uses thereof
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention...
US-9,493,519 Toxin in type A Clostridium perfringens
The present disclosure relates to a novel toxin of Type A C. perfringens and immunogenic compositions and vaccines thereof. The present disclosure further...
US-9,493,518 Compositions and methods for treating clostridium difficile-associated diseases
Described herein are isolated polypeptides each containing one or more receptor-binding sites of toxin A (tcdA) of Clostridium difficile (Cd), nucleic acids...
US-9,493,517 Conjugates comprising an antigen and a carrier molecule
The invention provides a conjugate comprising an antigen and a carrier molecule, wherein the carrier molecule comprises a spr0096 antigen and a spr2021 antigen....
US-9,493,516 Bacteriophage gene 3 protein compositions and use as amyloid binding agents
The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid...
US-9,493,515 Bacteriophage gene 3 protein compositions and use as amyloid binding agents
The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid...
US-9,493,514 Dimeric scaffold proteins comprising HIV-1 GP120 and GP41 epitopes
The present invention relates to novel peptides and methods for inducing an immune response in a subject against an antigen and for treatment, diagnosis and...
US-9,493,513 Polypeptides and their use
The present invention provides polypeptides that bind to inorganic solid surfaces, structures comprising such polypeptides, and methods of making such structures.
US-9,493,512 Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, ##STR00001## wherein the symbols have...
US-9,493,511 Cyclosporin analogs
Disclosed herein are novel analogs of cyclosporin, pharmaceutical compositions containing them, and methods for their use in the treatment of dry eye and other...
US-9,493,510 Peptidomimetic compounds
The present invention relates to inhibitors of protein-protein interactions (PPI). Specifically, the present invention relates to a structural informatics...
US-9,493,509 Triazole macrocycle systems
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming...
US-9,493,508 Polypeptide inhibitors of HSP27 kinase and uses therefor
The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for...
US-9,493,507 Glutathione-elevating compositions and uses thereof
Use of synthetic thiol-containing peptides as highly effective therapeutic and protective agents is described, in clinical and research applications where...
US-9,493,506 Macrocyclic hepatitis C serine protease inhibitors
The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said...
US-9,493,505 Macrocyclic modulators of the ghrelin receptor
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin...
US-9,493,504 Radioconjugation method
The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling a biological targeting molecule...
US-9,493,503 Certain chemical entities, compositions, and methods
Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.
US-9,493,502 Ribofuranosyl purine compounds, methods for preparing the same and use thereof
The present invention relates to the compounds of the formulae (I) and (I-1) and the process for preparing the same, uses of the compounds for the treatment of...
US-9,493,501 Methyltransferase inhibitors for treating cancer
Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structure ##STR00001## and are useful in the treatment of cancer...
US-9,493,500 Fluorinated pyrimidine analogs and methods of use thereof
The present invention provides fluorinated 5-aza-2'-deoxycytidine compounds, such as 2',2'-difluoro-5-aza-2'-deoxycytidine, compositions that include the...
US-9,493,499 Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as...
The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying...
US-9,493,498 Oligosaccharide-protein conjugates
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions...
US-9,493,497 Carbamate glycolipid and use thereof
The invention provides a compound effective as an antitumor active agent or vaccine adjuvant and an intermediate useful for the synthesis of the compound, as...
US-9,493,496 Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same
The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is...
US-9,493,495 Processing biomass
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
US-9,493,494 Phosphinine oxide derivative and preparation method thereof
Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an...
US-9,493,493 Nucleotide analogs
Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus...
US-9,493,492 Compound, manufacturing method therefor, and method for manufacturing optically active .alpha.-aminophosphonate...
A method for producing a compound represented by General Formula (1), the method including: reacting a compound represented by General Formula (3) and a...
US-9,493,491 Method of separating acids from chemical reaction mixtures by means of apolar amines
A process for the removal of acids from reaction mixtures, comprising at least one product of value which is sparingly soluble in water, by at least one unpolar...
US-9,493,490 Boron-containing small molecules
This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds. ##STR00001##
US-9,493,489 Boron-containing small molecules as anti-protozoal agents
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as...
US-9,493,488 Carbazole end capped bipyridine compounds and process for preparation thereof
The present invention is to provide highly solid state emissive fluorophores of the formula 1 and 2 useful for the solid state lighting. The formula 1 and 2...
US-9,493,487 3-(1H-imidazo[4,5-C]pyridin-2-YL)-1H-pyrazolo[3,4-B]pyridine and therapeutic uses thereof
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
US-9,493,486 Diazaspirocycloalkane and azaspirocycloalkane
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, Y and W are as described herein, compositions...
US-9,493,485 Spirocyclic dihydro-thiazine and dihydro-oxazine BACE inhibitors, and compositions and uses thereof
Compounds are provided having a structure according to Formula (I): wherein A.sub.1, A.sub.2, A.sub.3, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6,...
US-9,493,484 Heterocyclic compound and use thereof
Provided is a compound having an AMPA receptor function enhancing action, and useful as a prophylactic or therapeutic drug for depression, schizophrenia,...
US-9,493,483 Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable...
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