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Patent # Description
US-9,499,616 Modulated lysine variant species compositions and methods for producing and using the same
The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and...
US-9,499,615 Multiple-variable dose regimen for treating idiopathic inflammatory bowel disease
Multiple-variable dose methods for treating TNF.alpha.-related disorders, including Crohn's disease and psoriasis, comprising administering TNF.alpha....
US-9,499,614 Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides...
The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins...
US-9,499,613 Notch1 receptor binding agents and methods of use thereof
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means...
US-9,499,612 Antigen binding constructs
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an...
US-9,499,611 Anti-NGF compositions and use thereof
The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the...
US-9,499,610 Antibodies specific to pyroglutamated A.beta.
The present disclosure relates to antibodies specific for pyroglutamated A.beta., as well as their use in the treatment of Alzheimer's disease and as use in...
US-9,499,609 Monoclonal antibodies against claudin-18 for treatment of cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including...
US-9,499,608 Bispecific monoclonal antibody therapeutics against West Nile virus with improved CNS penetration
The plant-based production of a therapeutic antibody against West Nile Virus is disclosed.
US-9,499,607 Anti-dengue virus antibodies and uses thereof
The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as...
US-9,499,606 Compositions of, and methods for, alpha-1 anti trypsin Fc fusion molecules
A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for...
US-9,499,605 Multivalent heteromultimer scaffold design and constructs
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein...
US-9,499,604 Trail mutant membrane-penetrating peptide-alike and methods of preparation thereof
The invention mainly relates to the field of genetic engineering drugs, in particular to a mutant cDNA sequence obtained by mutating valine at position 114,...
US-9,499,603 PD-1 antibodies
A humanised agonistic antibody which binds human PD-1 comprising a heavy chain and a light chain wherein the variable domain of the heavy chain comprises the...
US-9,499,602 Non-hemolytic LLO fusion proteins and methods of utilizing same
The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a...
US-9,499,601 Molecular probe for sphingolipids
There is presently provided a probe comprising an isolated sphingolipid binding domain (SBD) polypeptide, wherein the isolated SBD polypeptide is capable of...
US-9,499,600 Long-acting single-chain insulin analogues
A single-chain insulin analog containing a basic side chain at position A8 (Arginine, Histidine, Lysine, or Ornithine), a basic side chain at position B29...
US-9,499,599 Composition and methods for stimulating gastrointestinal motility
The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus...
US-9,499,598 Mutants of IL-29
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences...
US-9,499,597 Methods and compositions for treating Huntington's disease
Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides...
US-9,499,596 Compositions and methods for the treatment of immune related diseases
The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.
US-9,499,595 Development of influenza A antivirals
The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the...
US-9,499,594 Biofilm prevention, disruption and treatment with bacteriophage lysin
The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having...
US-9,499,593 Modified biotin-binding protein, fusion proteins thereof and applications
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins...
US-9,499,592 Transcription activator-like effectors
Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.
US-9,499,591 Truncated L1 protein of human papillomavirus type 52
Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at...
US-9,499,590 Antibodies against and methods for producing vaccines for respiratory syncytial virus
The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to...
US-9,499,589 Chimeric vaccines
The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a...
US-9,499,588 Flaviviruses expressing the prM, E, and NS1 proteins of other flaviviruses and uses thereof
This invention provides flavivirus vaccines that comprise live-attenuated flaviviruses and methods of making and using these vaccines. The flavivirus vaccines...
US-9,499,587 Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
The present invention is directed to a novel class of antimicrobial agents called .gamma.-AApeptides. The current invention provides various categories of...
US-9,499,586 Anticancer and anti-obesity cyclic peptide agents
A compound having formula (I) or formula (II): ##STR00001## for use in anticancer or anti-obesity.
US-9,499,585 Bioactive peptide complexes
Herein disclosed are bioactive peptides and proteins having immunomodulating and antiviral activity, more particularly histidine-rich bioactive peptide...
US-9,499,584 GPCR with improved cell surface expression
The present invention surprisingly shows that the addition of a heterologous viral-GPCR (G protein-coupled receptor) derived sequence at the amino terminal end...
US-9,499,583 Antibacterial antisense oligonucleotide and method
A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by ...
US-9,499,582 Compositions and methods for increasing carnitine level in muscle tissue
Compositions and methods utilizing thiol-containing short peptides having the sequence Cys-Lys-Met-Cys (SEQ ID NO: 1) and optionally N- and C-terminal...
US-9,499,581 Compositions comprising enzyme-cleavable oxycodone prodrug
The embodiments provide Compound KC-8, N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]- -arginine-glycine-malonic acid, or acceptable...
US-9,499,580 Method for incorporating internal polar and ionizable groups in proteins
Internal polar and ionizable groups are essential for enzymatic catalysis, proton transport, redox reactions, and many other functional properties of proteins....
US-9,499,579 Branched chain-containing aromatic compound
The present invention provides a particular branched chain-containing aromatic compound. The branched chain-containing aromatic compound of the present...
US-9,499,578 Massively parallel synthesis of biopolymeric arrays
Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic...
US-9,499,577 Natural and synthetic compounds for treating cancer and other diseases
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast,...
US-9,499,576 Compound, nucleic, acid, method for producing nucleic acid, and kit for producing nucleic acid
The present invention relates to a compound represented by Formulas 1, 2 or 3 as described herein, and a nucleic acid each of which contains a dye exhibiting an...
US-9,499,575 Synthesis of carbohydrate-based surfactants
The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate-based surfactants include...
US-9,499,574 Arsenoplatin anti-cancer agents
Disclosed are compound having the structure of formula (I): ##STR00001## wherein M is Pt, Pd or Ni; Q is As, Sb or Bi; Z.sup.1 is N; Z.sup.2 is O or S;...
US-9,499,573 Iridium-based complexes for ECL
The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g....
US-9,499,572 Phosphatidylalkanols and compositions thereof
The present invention discloses a composition comprising a compound of formula I and a deuterated solvent. The deuterated solvent is miscible with water in any...
US-9,499,571 Germanium- and zirconium-containing compositions for vapor deposition of zirconium-containing films
Disclosed are Germanium- and Zirconium-containing precursors having one of the following formulae: ##STR00001## wherein each R.sup.1, R.sup.2, R.sup.3,...
US-9,499,570 Boron containing small molecules
Compounds, pharmaceutical formulations, and methods of treating anti-inflammatory conditions and/or helminth-associated diseases are disclosed.
US-9,499,569 Spherical magnesium halide adduct, a catalyst component and a catalyst for olefin polymerization prepared therefrom
A magnesium halide adduct represented by the formula (I): MgX.sub.2.mROH.nE.pH.sub.2O, in which X is chlorine, bromine, a C.sub.1-C.sub.12 alkoxy, a...
US-9,499,568 Heterocyclic compound and use thereof
Provided is a compound represented by the formula (I): ##STR00001## wherein each symbol is as defined in the specification, or a salt thereof, which has an...
US-9,499,567 Piperidine/piperazine derivatives
The invention further relates to a DGAT inhibitor of formula ##STR00001## including any stereochemically isomeric form thereof, wherein A represents CH or N;...
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