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Patent # Description
US-9,499,516 Nitrogen-containing heterocyclic compound
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the...
US-9,499,515 Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same
Provided are an efficient method for producing 3,4-dihydroisoquinoline derivatives and useful production intermediates thereof. Provided is a method for...
US-9,499,514 Antiproliferative compounds and methods of use thereof
Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as...
US-9,499,513 Acid generators and photoresists comprising same
Acid generator compounds are provided that are particularly useful as photoresist composition components. Preferred acid generators include cyclic sulfonium...
US-9,499,512 Process for producing a cyclic acetal in a heterogeneous reaction system
A process for producing a cyclic acetal is disclosed. According to the process, a formaldehyde source is combined with an aprotic compound and contacted with a...
US-9,499,511 N-substituted hydroxylamine derivatives with carbon-based leaving groups
The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds,...
US-9,499,510 Pro-drug compounds
A compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein Z.sub.1, Z.sub.2, and Z.sub.3, Q, R.sup.2, A, and R.sup.1 are as defined in...
US-9,499,509 Dihydrochalcone derivatives and their use as antibiotic agents
A compound of formula (I) as well as pharmaceutical compositions comprising same is provided. An extract of a plant belonging to a species of Populus, the...
US-9,499,508 2-pyrones
The present invention relates to the use of compounds of the formula (I) for the care, preservation or improvement of the general condition or appearance of the...
US-9,499,507 Method for preparing 5-amino-benzoyl-benzofuran derivatives
The invention relates to a method for preparing 5-amino-benzoyl-benzofuran derivatives having the general formula in which R.sub.1 is hydrogen or an alkyl or...
US-9,499,506 Method for preparing 2,5-furandicarboxylic acid
A method for preparing 2,5-furandicarboxylic acid (FDCA) by oxidizing 5-hydroxymethylfurfural (HMF) in water in the presence of a weak base and a supported...
US-9,499,505 Process for the epoxidation of olefins
The subject invention is related to a process for the epoxidation of olefin with peroxide, comprising reacting peroxide with olefin in the presence a solvent,...
US-9,499,504 Crystalline form of vortioxetine hydrobromide
The present invention is directed to a crystalline compound comprising a hydrobromide acid (HBr) salt of a compound of formula (I) ...
US-9,499,503 Mitotic kinesin inhibitors and methods of use thereof
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. ##STR00001##
US-9,499,502 5-substituted iminothiazines and their mono- and dioxides as BACE inhibitors, compositions, and their use
The present invention discloses certain iminothiazine compounds and mono- and dioxides thereof, including compounds Formula (I): and tautomers and stereoisomers...
US-9,499,501 2-Mercaptobenzothiazole manganese zinc, preparation method therefor and application thereof
The present invention belongs to the technical field of agricultural fungicides and discloses a 2-mercaptobenzothiazole manganese zinc, preparation method...
US-9,499,499 Valsartan salts
The invention relates to new salts of valsartan or crystalline, also partly crystalline and amorphous salts of valsartan, the respective production and usage,...
US-9,499,498 Process for the preparation of triazine carbamates
This invention relates to a process for the preparation of triazine carbamates by reacting a mixture of an aminotriazine A having at least two amino groups per...
US-9,499,497 Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable...
US-9,499,496 Inhibitors of respiratory syncytial virus
Described herein are compounds, pharmaceutical compositions and methods for treating a respiratory syncytial virus infection in a subject, or for inhibiting...
US-9,499,495 Quinazolines and azaquinazolines as dual inhibitors of RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways
The present application provides novel quinazolines and azaquinazolines and pharmaceutically acceptable salts thereof. Also provided are methods for preparing...
US-9,499,494 Pyrimidine-2,4,6-triones for use in the treatment of amyotrophic lateral sclerosis
The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating...
US-9,499,493 2,4-pyrimidinediamine compounds and their uses
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical...
US-9,499,492 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group
The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives containing a sulfoximine group of general formula (I) as...
US-9,499,491 One pot process for the preparation of telmisartan
A process for the preparation of bromine free telmisartan in one pot starting from 2-cyano-4'-methyl biphenyl. The process uses raw materials which are readily...
US-9,499,490 Fluorophenyl pyrazol compounds
The present invention provides a compound of the Formula: wherein X is selected from the group consisting of, R is selected from the group consisting of H and...
US-9,499,489 Myxovirus therapeutics, compounds, and uses related thereto
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical...
US-9,499,488 Vitamin D receptor agonists and uses thereof
This invention features vitamin D receptor agonists, and their use in treating bone disorders, cardiovascular disease, hyperparathyroidism, immune disorders,...
US-9,499,487 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, X, R.sup.4, R.sup.5, and R.sup.6 are as...
US-9,499,486 Kinase inhibitor
There is provided a compound of formula I, ##STR00001## which compound has anti-inflammatory activity (e.g. through inhibition of one or more of members of:...
US-9,499,485 Compounds that are S1P modulating agents and/or ATX modulating agents
Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
US-9,499,484 Indole, indoline derivatives, compositions comprising them and uses thereof
The invention provides indole and indoline derivatives and slats thereof, compositions comprising them and uses thereof for the treatment of diseases and...
US-9,499,483 Crystal of pyrrole derivative and method for producing the same
The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic...
US-9,499,482 Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These...
US-9,499,481 Method for preparing lactames, comprising a photonitrosation step, followed by a Beckmann transposition step
The invention relates to a method for preparing lactames, according to which a photonitrosation of a cycloalkane is carried out using nitrosyl chloride (NOCI)....
US-9,499,480 Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human...
US-9,499,479 Molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
This invention provides a compound having the structure: ##STR00001## wherein R.sub.1 is H, halogen, --NR.sub.5R.sub.6, --NR.sub.5--C(.dbd.O)--R.sub.6,...
US-9,499,478 Substituted cyclopentanes for inducing hair growth
Provided herein, inter alia, are, methods of using esters of bimatoprost with the Formula (I): ##STR00001##
US-9,499,477 Hydroxamic acid derivative
Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity...
US-9,499,476 Acetamide stereoisomer
The compound of formula (I) ##STR00001## is a water-stable, long acting .beta..sub.2-selective adrenoceptor agonist useful as a bronchodilator in the...
US-9,499,475 Process for the preparation of arformoterol or salt thereof
Provided is an improved process for the preparation of arformoterol L-(+)-tartrate, and more specifically provided is a novel process for the preparation of...
US-9,499,474 Process for producing arylamines
The invention relates to a process for producing compounds containing at least one arylamino group by means of a coupling reaction of an amino compound with an...
US-9,499,473 Method for producing nitrous acid ester, and method for producing dialkyl oxalate and dialkyl carbonate
A method for producing nitrous acid ester in which nitric oxide, oxygen, and an alcohol are reacted, thereby generating nitrous acid ester includes a step of...
US-9,499,472 Aspartylamide inhibitors of excitatory amino acid transporters
The compounds of the invention are inhibitors of excitatory amino acid transporters (EAAT) that penetrate the blood-brain barrier to access the central nervous...
US-9,499,471 Biphenyl compounds for use in treating malaria and other parasitic disorders
The present invention relates to a compound of formula (I) ##STR00001## as defined herein.
US-9,499,470 Process for the carbonylation of dimethyl ether
Process for preparing methyl acetate by the carbonylation of dimethyl ether with carbon monoxide in the presence of hydrogen and a zeolite catalyst. In a first...
US-9,499,469 Production method of ketomalonic acid compound
Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalinic acid diesters, or a hydrate thereof, by a method more...
US-9,499,468 3-acyloxymethyl-3-butenyl carboxylate compound and method for producing 4-alkyl-3-methylenebutyl carboxylate
Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More...
US-9,499,467 Ortho-fluoro substituted compounds for the treatment of metabolic diseases
There is provided novel fluoro-substituted compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and...
US-9,499,466 Diene-based carboxylate anion and salt thereof, and polymerizable or curable composition thereof
The claimed invention provides a novel compound not having been studied before, that is, a diene carboxylate anion that contains a specific structure, and a...
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