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Patent # Description
US-9,506,066 Repressor on IFN-.lamda. promoter and siRNA against GATA1, EVI1, and CRX to alter IFN-.lamda. gene activity
The present invention is directed to the identification of a novel repressor located between .about.1.2 kb to .about.1.6 kb from the translation start site of...
US-9,506,065 Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or...
US-9,506,064 Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy
The present invention relates to compositions and methods for delivery of siRNA to specific cells or tissue. More particularly, the present invention relates to...
US-9,506,063 SiRNA compositions and methods for treatment of HPV and other infections
The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human...
US-9,506,062 Targeting microRNAs for the treatment of liver cancer
Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide,...
US-9,506,061 Methods and compositions involving miRNA and miRNA inhibitor molecules
The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover,...
US-9,506,060 LNA antisense oligonucleotides for the modulation of Myc expression
The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc...
US-9,506,059 Modifications for antisense compounds
The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from...
US-9,506,058 Compositions for treating muscular dystrophy
Improved compositions and methods for treating muscular dystrophy by administering antisense molecules capable of binding to a selected target site in the human...
US-9,506,057 Modifications for antisense compounds
The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from...
US-9,506,056 Nucleic acid functionalized nanoparticles for therapeutic applications
Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the...
US-9,506,055 Reducing adapter dimer formation
Provided herein is a method of reducing adapter dimer formation comprising contacting a sample comprising target nucleic acid sequences with 5' and 3' adapters...
US-9,506,054 Method for acquiring a heat-stable antibody-displayed phage
Using a biopanning method, a heat-stable antibody-displayed phage is acquired. More particularly, first, an antibody-displayed phage library aqueous solution...
US-9,506,053 Methods of selecting biologic-producing cell lines by next generation sequencing
An optimized multi-step cell line screening method based on next generation sequencing (NGS) and mass spec (MS) is disclosed. The method helps reduce variants...
US-9,506,052 Modified factor VIII and factor IX genes
The present invention relates to a modified and optimized Factor VIII or Factor IX nucleic acid for inclusion in a chimeric virus vector. Use of such vector can...
US-9,506,051 Tau protease compositions and methods of use
Disclosed are mammalian tau proteases, as well as proteolytically-active fragments, variants, and mutants thereof. Also disclosed are polynucleotides and...
US-9,506,050 Polypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides,...
US-9,506,049 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
US-9,506,048 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity, catalytic domains, and cellulose binding domains and polynucleotides...
US-9,506,047 Alpha-amylases
The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the...
US-9,506,046 Polypeptides having amylolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having amylolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
US-9,506,045 DNA polymerases with improved activity
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful...
US-9,506,044 Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates...
US-9,506,043 Diaphorase
A novel diaphorase; a method for producing the diaphorase; and use of the diaphorase are provided. The diaphorase comprises any one of the following...
US-9,506,042 Glucose dehydrogenase
The present invention provides a novel glucose dehydrogenase that has excellent substrate specificity, specific activity, thermal stability, and the like, and...
US-9,506,041 Delivery of packaged RNA to mammalian cells
Described herein are compositions relating to alphavirus-based virus-like particles (VLPs) and methods for making and using the described VLPs. The described...
US-9,506,040 Prevascularized constructs for implantation to provide blood perfusion
This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to...
US-9,506,039 Efficient method for establishing induced pluripotent stem cells
The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of...
US-9,506,038 Extracellular matrix compositions for the treatment of cancer
The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM)...
US-9,506,037 Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
A bicellular vascular population derived from human pluripotent stem cells (hPSCs) undergoes morphogenesis and assembly in a synthetic hydrogel. It is shown...
US-9,506,036 Differentiation of human embryonic stem cells
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present...
US-9,506,035 Methods and compositions to support transplanted tissue integration and innosculation with adipose stromal cells
The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for ...
US-9,506,034 Method of enriching for pancreatic endoderm cells
The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells...
US-9,506,033 Compositions and methods for inducing myoblast differentiation and myotube formation
Provided herein are methods of inducing differentiation of a mammalian myoblast into a mammalian myocyte that include contacting a mammalian myoblast with an...
US-9,506,032 Engineered biological pacemakers
Biological pacemakers engineered to intrinsically generate rhythmic excitations are disclosed. In addition, methods of producing the biological pacemakers are...
US-9,506,031 Methods and materials for increasing potency of cells
Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified...
US-9,506,030 Compounds and methods for enhanced cellular uptake
Described herein are conjugated modified oligonucleotides that are complementary to a target RNA. The conjugate facilitates cellular uptake of the modified...
US-9,506,029 Responsive cell culture hydrogel
The present invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell...
US-9,506,028 Mechanical cell lysis apparatus
The present invention relates to a cell lysis apparatus and a manufacturing method thereof, and more particularly, to a cell lysis apparatus, which mechanically...
US-9,506,027 Microbubble devices, methods and systems
A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator...
US-9,506,026 Culture apparatus provided with heat pipe
A culture apparatus includes a heat insulating box main body having an inner box; a culture vessel; a duct and a circulation blower forcing convection of a gas...
US-9,506,025 Cultured muscle produced by mechanical conditioning
A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a...
US-9,506,024 Circulation system
A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or...
US-9,506,023 Stabilised particles in an alcoholic beverage
The invention relates to an alcoholic beverage containing between 15 and 150 g/l of a particulate nut material, wherein the nut material has a particle size,...
US-9,506,022 Cellulose-based disaggregatable paper containing detergents
A soaped paper which will disaggregate in aqueous liquids comprising: a. cellulose-based fiber pulp: 50-90% by weight; b. disaggregating agent: 30-3% by weight;...
US-9,506,021 Glass-electrode responsive-glass cleaning liquid and method for cleaning glass-electrode responsive-glass
To maintain a uniform etching rate during cleaning of a responsive glass in a glass electrode, a responsive-glass cleaning liquid for a glass electrode 1 serves...
US-9,506,020 Automatic dishwashing composition
An automatic dishwashing composition offering good performance especially in the removal of stubborn stains, such as tea stains, comprises a chelating agent...
US-9,506,019 Silicone nanoemulsion comprising alkylene glycol alkyl ether
Silicone nanoemulsions that include alkylene glycol alkyl ethers. Treatment compositions that include such silicone nanoemulsions. Methods of making such...
US-9,506,018 Microfibrous cellulose and alkaline earth metal ion structured surfactant composition
An aqueous composition comprising at least one surfactant; a suspending agent comprising micro fibrous cellulose; 10 to 600 ppm of an alkaline earth metal ion,...
US-9,506,017 Aqueous cleaning compositions including an alkyl 3-hydroxybutyrate
Cleaning compositions and methods of making and using the same are provided. The cleaning compositions of the present invention may include at least one alkyl...
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