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Patent # Description
US-9,512,209 Methods of modulating inflammasome activity to treat inflammatory conditions
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the...
US-9,512,208 Immunoglobulin constant region FC receptor binding agents
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are...
US-9,512,207 Anti-NPC2 monoclonal antibodies and a method of detecting fatty liver tissue, cancer cells or cancer tissue by...
The present invention is related to anti-NPC2 monoclonal antibodies, which against NPC2 or glycosylated-NPC2; and is related to a method of detecting fatty...
US-9,512,206 Anti-lipoarabinomannan antibody and immunoassay for acid-fast bacillary infection using the antibody
The present invention provides a monoclonal antibody that specifically binds to acid-fast bacillary lipoarabinomannan, particularly tubercle bacillary...
US-9,512,205 Monoclonal antibodies to anthrax protective antigen
The characterization and isolation of F20G75, F20G76 and F20G77, anti-PA monoclonal antibodies which also have neutralizing activities is described. The...
US-9,512,204 Humanized pertussis antibodies and uses thereof
The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present...
US-9,512,203 Single-domain antibodies that bind to HIV-1 Nef with high affinity
The invention relates to antibody fragments with simple heavy chain or sdAbs, characterized in that they consist of anti HIV Nef-protein fragments corresponding...
US-9,512,202 Multi-strain-reactive antibodies for therapy and diagnosis of influenza
The invention relates to a method for isolating a polypeptide reactive to influenza A hemagglutinin, comprising the steps of preparing a library of nucleic acid...
US-9,512,201 Human binding molecules capable of binding to and neutralizing hepatitis B viruses and uses thereof
The disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to Hepatitis B viruses, and have a broad neutralizing activity...
US-9,512,200 Personalized production of biologics and method for reprogramming somatic cells
The invention provides a method for producing polypeptide protein products and nucleic acid products having reduced levels of antigenicity in an animal being...
US-9,512,199 Fibronectin cradle molecules and libraries thereof
The here described invention discloses a combination of a top and bottom loop binder library using the CD and the FG loops of a number of FnIII domains (FnIII)...
US-9,512,198 FVIII peptides for immune tolerance induction and immunodiagnostics
The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients...
US-9,512,197 High affinity NY-ESO T cell receptors
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived...
US-9,512,196 Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
The present invention is based on a novel, alternatively spliced human isoform of MD-2 (MD-2s). In addition, the present invention relates to modified MD-2...
US-9,512,195 Insulin derivatives containing additional disulfide bonds
The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.
US-9,512,194 Modified IL-13 polypeptides
Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13R.alpha.2, relative...
US-9,512,193 P15 protein variant and use thereof for preventing or treating cancer
A p15 protein variant; a polynucleotide encoding the p15 protein variant; a method for preparing the p15 protein variant; a pharmaceutical composition...
US-9,512,192 Collagen-binding synthetic peptidoglycans, preparation, and methods of use
This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding...
US-9,512,191 Methods and compositions for treating neurodegenerative disorders and alzheimer's disease and improving normal...
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods...
US-9,512,190 Malaria vaccine
The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in...
US-9,512,189 Optimized antigens of pneumocystis and use thereof
Immunologically active agents are described, including isolated Pneumocystis A 12 protein or polypeptides; immunogenic conjugates containing Pneumocystis A 12...
US-9,512,188 Isolated polynucleotides and methods and plants using same for regulating plant acidity
Provided are isolated polynucleotides comprising a nucleic acid sequence encoding a polypeptide, wherein the polypeptide modulates acidity of a plant. Also...
US-9,512,187 Mutant Bacillus thuringiensis proteins and genes encoding the same with improved insecticidal activity and use...
The present disclosure discloses novel Cry1Ac mutants with improved insecticidal activity and/or spectrum against pests belong to Order lepidoptera. Also...
US-9,512,186 Recombinant strain of Mycobacterium bovis bacillus calmette-guerin (BCG), immunogenic composition and use
The present invention relates to recombinant Mycobacterium strain that encodes the mutated Escherichia coli LT heat-labile toxin or the A subunit of the mutated...
US-9,512,185 Fusion protein comprising diphtheria toxin non-toxic mutant CRM197 or fragment thereof
Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to...
US-9,512,184 Hepatitis C virus particles, vaccines, compositions and methods related thereto
This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and...
US-9,512,183 Synthetic hepatitis C genome and methods of making and use
Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic...
US-9,512,182 Vaccine antigens that direct immunity to conserved epitopes
A method of identification and elimination of immunodominant epitopes to elicit a response to secondary epitopes, especially conserved structures, is described,...
US-9,512,181 Fusion proteins of ciliate granule lattice proteins, granular protein particles thereof, and uses therefor
This invention is directed to methods for the production of immunogenic granular particles. In certain embodiments, the invention is directed to methods and...
US-9,512,180 Compstatin analogs
The disclosure describes compstatin analogs and methods of using such analogs for the treatment of complement-related disease and disorder.
US-9,512,179 Compositions and methods for regulating glucose metabolism
The present disclosure provides compositions for regulating glucose metabolism. The compositions provide for reduced levels of p75.sup.NTR and/or reduced...
US-9,512,178 Neurogenic brain-derived neurotrophic factor peptides
Five tetra peptides corresponding to different active regions of brain derived neurotrophic factor (BDNF) that are neurotrophic and can modulate BDNF signaling...
US-9,512,177 Method for producing .gamma.-glutamyl-valyl-glycine crystal
The present invention provides a method for efficiently producing a .gamma.-glutamyl-valyl-glycine crystal. Specifically, the present invention provides a...
US-9,512,176 Age inhibitors
The invention relates to a compound having general formula I, wherein: X represents CH.sub.2, C.dbd.O, C.dbd.S or CHOH, R.sub.1 represents an amino acid...
US-9,512,175 Macrocyclic inhibitors of flaviviridae viruses
Provided are compounds of Formula: ##STR00001## and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided...
US-9,512,174 Synthesis, structure and use of functionalized naphthalenes
Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful...
US-9,512,173 Method for separating and purifying protein from plants using cellulose and cellulose binding domain
The present invention relates to a method of isolating a protein containing a cellulose binding domain from plants using various structures of cellulose and/or...
US-9,512,172 Ethanol dependence of alpha1 antitrypsin C-terminal Lys truncation by basic carboxypeptidases
Methods of preparing alpha-1-antiproteinase inhibitor and controlling the amount of des-lys alpha-1-antiproteinase inhibitor in the preparation, and...
US-9,512,171 Functional molecule and manufacturing method therefor
A novel method for efficiently manufacturing a functional molecule with affinity for a target substance is provided along with a functional molecule...
US-9,512,170 Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
The present disclosure is generally directed to neuroactive 13,17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for...
US-9,512,169 3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical...
The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to...
US-9,512,168 Compound, composition and method for treating and/or ameoliorating kidney disease
Disclosed herein are compositions and methods for the treatment or prophylaxis of a subject having or susceptible to a kidney disease. The method includes the...
US-9,512,167 Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides...
US-9,512,166 Cocrystals of progesterone
Disclosed herein are cocrystals of progesterone and a coformer containing a six-membered aromatic ring having at least one substituent possessing a carbonyl...
US-9,512,165 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein, R.sup.1, R.sup.2,...
US-9,512,164 Oligonucleotide end caps
Modified nucleic acids are described herein, including pharmaceutical compositions comprising the modified nucleic acids, and methods of using the modified...
US-9,512,163 Compositions and methods for conjugating oligonucleotides
An oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligonucleotide derivative are disclosed. wherein R.sup.3 is a...
US-9,512,162 Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites and oligonucleotides
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated...
US-9,512,161 Hydroxyl, keto, and glucuronide derivatives of ...
The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylprop- ...
US-9,512,160 Antibacterial S-heterosubstituted disulfides
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including...
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