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Patent # Description
US-9,512,159 Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid A (3D-MLA)
The invention relates to a method for extracting lipopolysaccharide (LPS) from rough trough mutant bacteria cells by extracting the cells with an aqueous...
US-9,512,158 Enhanced immunogenicity of tumor associated antigens by addition of alphagal epitopes
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic...
US-9,512,157 Methods for preparing ruthenium carbene complexes and precursors thereto
Methods of preparing ruthenium carbene complex precursors are disclosed herein. In some embodiments, the methods include reacting a ruthenium refinery salt with...
US-9,512,156 Carbon monoxide releasing rhenium compounds for medical use
The present invention relates to new rhenium compounds of formula (I) ##STR00001## with medical utility, corresponding pharmaceutical compositions as well as...
US-9,512,155 Chiral phosphines for palladium-catalyzed asymmetric .alpha.-arylation of ester enolates to produce tertiary...
The disclosure provides new and improved methods for the Pd-catalyzed asymmetric .alpha.-arylation of ester compounds, which produce the corresponding...
US-9,512,154 .sup.18FDG multimeric positron emission tomography imaging agents
The present invention discloses .sup.18FDG conjugated positron emission tomography (PET) imaging agents. In particular, the present invention discloses a cancer...
US-9,512,153 Prodrugs of vitamine K
The invention relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester...
US-9,512,152 Phospholipid compound containing unsaturated fatty acid derivative having cyclopropane ring
The invention provides a phospholipid compound containing unsaturated fatty acid having a cyclopropane ring such as ...
US-9,512,151 Product containing monomer and polymers of titanyls and methods for making same
A compound of Formula (II) and (III), or a mixture of any two or more thereof; wherein M is Ti or Zr; R.sup.3 at each occurrence is H, F, Cl, Br, I, CN,...
US-9,512,150 Thermal conductive compositions and methods for their preparation and use
Thermal conductive compositions, methods for their preparation, and use are provided, which include, for example, as thermal sinks and other uses.
US-9,512,149 Reactive compound
A reactive compound represented by the following formula (I): ##STR00001## in the formula (I), Z represents a divalent group. A plurality of Y may be the same...
US-9,512,148 Boron-containing diacylhydrazines
The present disclosure provides boron-containing diacylhydrazines having Formula I: ##STR00001## and the pharmaceutically acceptable salts and solvates...
US-9,512,147 Organoboron compounds and methods of making organoboron compounds
Embodiments of the present disclosure provide for methods of making an organoboron compound, organoboron compounds, and the like.
US-9,512,146 Azolium metal-organic frameworks
Disclosed herein are metal-organic frameworks comprising at least two azolium rings. The azolium groups are used as a strategy for controlling catenation and...
US-9,512,145 Porous reactive framework
This disclosure relates to porous frameworks for gas separation, sensing and drug/biomolecule delivery. More particularly, the disclosure relates to reactive...
US-9,512,144 Imidazothiazole sufonamides as nematicides
Disclosed are compounds of formula (I) which possess nematicidal properties ##STR00001## wherein the structural elements have the meaning as indicated in the...
US-9,512,143 Histone deacetylase inhibitors
The compounds provided herein are phenyl analine amides and are useful for inhibiting histone deacteylase ("HDAC") enzymes, such as HDAC1, HDAC2, and HDAC3.
US-9,512,142 Tricyclic triazolic compounds
The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the...
US-9,512,141 Pyrazine derivatives as CB2 receptor agonists
The invention relates to a compound of formula (I) wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of formula (I)...
US-9,512,140 (Thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT.sub.2A...
A dual H1 inverse agonist/5-HT.sub.2A receptor antagonist of the formula: ##STR00001## its uses, and methods for its preparation are described.
US-9,512,139 Conformationally constrained, fully synthetic macrocyclic compounds
Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of formulae Ia and Ib are constituted by three distinct molecular parts:...
US-9,512,138 Compositions and methods for treating cancer
Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative...
US-9,512,137 Organic electroluminescence device
An organic electroluminescence device sequentially includes an anode, an emitting layer, an electron-transporting region, and a cathode, the ...
US-9,512,136 Organic electroluminescent materials and devices
Novel organic compounds containing an imidazole core and electron donor and acceptor fragments are provided. By selection of the disclosed donor and acceptor...
US-9,512,135 Oligomer-opioid agonist conjugates
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered...
US-9,512,134 Spiro-lactam NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
US-9,512,133 NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
US-9,512,132 Pyrazole compounds as CB2 agonists
The invention relates to a compound of formula (I) ##STR00001## wherein A.sup.1 to A.sup.3 and R.sup.1 to R.sup.3 are defined as in the description and in the...
US-9,512,131 Organic semiconductor material for organic transistor, and organic transistor element
Provided are a semiconductor material for an organic transistor having a high charge mobility, solvent solubility, oxidation stability, and satisfactory film...
US-9,512,130 Substituted imidazopyridazines
The present invention relates to substituted imidazopyridazine compounds, to methods of preparing said compounds, to pharmaceutical compositions and...
US-9,512,129 Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- ...
Provided herein are formulations, processes, solid forms and methods of use relating to ...
US-9,512,128 Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
The present invention relates to aryl sulphide and aryl sulphoxide derivatives, to their use as acaricides and insecticides for controlling animal pests and to...
US-9,512,127 Process for the production of speherical tetranitroglycouril
A spherical morphology of the high explosive tetranitroglycoluril (TNGU) has been discovered. This new morphology exhibits approximately a twofold improvement...
US-9,512,126 Substituted imidazopyridazines
The present invention relates to substituted imidazopyridazine compounds of general formula I in which R.sup.3, R.sup.5 and A are as defined in the claims, to...
US-9,512,125 Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease...
US-9,512,124 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Provided herein are Aminopurine Compounds having the following structures: ##STR00001## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined herein,...
US-9,512,123 Compositions, uses and methods for making them
Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce...
US-9,512,122 Spirocyclic compounds as tryptophan hydroxylase inhibitors
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful...
US-9,512,121 [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof
Provided are [1,2,4]triazol[4,3-a]pyridine derivatives as shown in the general formula (I), a preparation method therefor, and a pharmaceutical composition...
US-9,512,120 Microbicidally active imidazopyridine derivatives
The present invention provides compounds of formula (I) wherein Y.sup.1, Y.sup.2, Y.sup.3, G, V.sup.1, V.sup.2, V.sup.3 and V.sup.4 are as defined in the...
US-9,512,119 Difluoromethylene compound
The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a...
US-9,512,118 Crystal of fused heterocyclic compound
The present invention relates to a crystal of 1-ethyl-7-methyl-3-{4-[(3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)oxy]phenyl- ...
US-9,512,117 Heteroaryl piperidine and heteroaryl piperazine derivatives as fungicides
Heteroarylpiperidine and -piperazine derivatives of the formula (I) ##STR00001## in which the symbols A, X, Y, L.sup.1, L.sup.2, G, Q, p, R.sup.1, R.sup.2 and...
US-9,512,116 Compounds that modulate intracellular calcium
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels....
US-9,512,115 Inhibitors
The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and...
US-9,512,114 Substituted aminopyrimidine compounds and methods of use
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form...
US-9,512,113 N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxylic thioamides and use thereof as herbicides
N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxylic acid thioamides of the general formula (I) are described as herbicides. ##STR00001## In this formula...
US-9,512,112 Substituted pyridines as P2X.sub.3 and P2X.sub.2/3 antagonists
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6...
US-9,512,111 N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ROR.gamma. activity and...
The invention provides tetrahydroquinoline and related compounds, pharmaceutical compositions, methods of inhibiting ROR.gamma. activity, reducing the amount of...
US-9,512,110 Phenyl and benzodioxinyl substituted indazoles derivatives
A compound of formula Ia: ##STR00001## The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such...
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