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Patent # Description
US-9,518,126 Vaccine comprising monocyte or immature myeloid cells (IMC) which were loaded with the ligand of natural killer...
The present invention relates to an immuno-therapeutic and prophylactic vaccine comprising monocytes or immature myeloid cells (IMCs) loaded with the ligand of...
US-9,518,125 Composition for diagnosing liver cancer and methods of diagnosing liver cancer and obtaining information for...
Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to...
US-9,518,124 Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases
The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding...
US-9,518,123 Compositions and methods for treatment of cancer
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T...
US-9,518,122 Endoglin antibodies
The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One...
US-9,518,121 Anti-Jagged1 antibodies and methods of use
The invention provides anti-Jagged1 antibodies and methods of using the same.
US-9,518,120 Anti-CXCR4 antibody and its use for the detection and diagnosis of cancer
The present invention provides a novel, isolated anti-CXCR4 antibody for use in the diagnosis of cancer. In particular, the antibody of the invention recognizes...
US-9,518,119 IL3R.alpha. antibody conjugates and uses thereof
The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R.alpha.) chain, and compositions comprising such antibodies....
US-9,518,118 Anti-HER2 antibodies and immunoconjugates
The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
US-9,518,117 Therapeutic CD47 antibodies
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, CD47, as well as monoclonal antibodies and...
US-9,518,116 Therapeutic CD47 antibodies
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, CD47, as well as monoclonal antibodies and...
US-9,518,115 Humanized anti-CD22 antibody
Disclosed are humanized RFB4 antibodies or antigen-binding fragments thereof. therapy of B-cell associated diseases, such as B-cell malignancies, autoimmune...
US-9,518,114 Treating bladder tumor cells using fibronectin attachment protein as a target
Composition and methods are disclosed for utilizing micro-aggregation of FAP-containing complexes to promote their fast internalization. This approach allows...
US-9,518,113 Monoclonal antibodies to interleukin 35 and methods of use thereof to inhibit regulatory T cell function
Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a...
US-9,518,112 TGF-.beta.1 specific antibodies and methods and uses thereof
Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-.beta.1) are provided,...
US-9,518,111 Compositions comprising a p75 tumor necrosis factor receptor/Ig fusion protein
The present invention relates to pharmaceutical compositions comprising a p75 tumor necrosis factor receptor/Ig fusion protein.
US-9,518,110 Antibody preparations
An antibody preparation suitable for intravenous administration in humans includes IgG, IgA and at least 5% IgM antibodies by weight of the total amount of...
US-9,518,109 Prevention, treatment and diagnosis of P. gingivalis infection
The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
US-9,518,108 Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of...
Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have...
US-9,518,107 Pharmaceutical compositions containing polypeptides derived from .alpha.-1 antitrypsin and methods of use thereof
Isolated polypeptides comprising the amino acid sequence of residues 378-413 of Mus musculus .alpha.-1-antitrypsyn (serpin A1c),active fragments thereof, and...
US-9,518,106 Collagen fibrillar construction
Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the...
US-9,518,105 Polypeptides derived from calcitonin receptors and methods of use
The present invention is based, in part, on our discovery of compositions and methods that can be used to treat a patient who has a compromised bone (due, for...
US-9,518,104 Compositions and methods for treating multiple sclerosis
Disclosed are polypeptides, compositions and methods for the treatment or prophylaxis of multiple sclerosis. The method involves the steps of administering a...
US-9,518,103 Optogenetic probes for measuring membrane potential
Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates...
US-9,518,102 Polypeptide for improving protein production in microorganisms of the phylum Labyrinthulomycota
The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel...
US-9,518,101 Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions...
US-9,518,100 Methods for increasing N-glycan occupancy and reducing production of hybrid N-glycans in Pichia pastoris...
Methods are disclosed for increasing the yield and N-glycosylation site occupancy of paucimannose or complex N-glycans of recombinant glycoproteins produced in...
US-9,518,099 Refolded chlorotoxin, chlorotoxin variant, refolded chlorotoxin variant, and preparation technology thereof
Disclosed are a folded chlorotoxin, a chlorotoxin variant and a folded chlorotoxin variant and their preparation technology. The folded chlorotoxin has a...
US-9,518,098 Uses of NANOG inhibitors and related methods
The present invention relates to substances and compositions thereof useful in the control of cancer stem cell persistence and concomitant tumor recurrence...
US-9,518,097 Identification and use of genes encoding amatoxin and phallotoxin
The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms....
US-9,518,096 Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or...
US-9,518,095 Scalable fermentation process
This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein...
US-9,518,094 Romidepsin solid forms and uses thereof
The present disclosure provides solid forms of a compound of formula I. In some embodiments, the present disclosure provides crystalline forms of Compound I. In...
US-9,518,093 Topical formulation of arginine-rich cyclic antimicrobial peptides
The present invention relates to cyclic cationic peptides and their use in the treatment of microbial infections.
US-9,518,092 Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
Template-fixed .beta.-hairpin peptidomimetics of the general formula (I) ##STR00001## wherein Z is a template-fixed chain of 12, 14 or 18 .alpha.-amino acid...
US-9,518,091 A4B7 peptide monomer and dimer antagonists
The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of .alpha.4.beta.7 to the mucosal addressin cell...
US-9,518,090 Compositions and methods for treating hepatitis B
The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a...
US-9,518,089 Metallothionein-derived peptide fragments
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT),...
US-9,518,088 Peptide-phospholipid conjugates
The present invention provides a peptide-phospholipid conjugate of Formula 1: ##STR00001## wherein: X is selected from the group consisting of...
US-9,518,087 Erythrocyte-binding therapeutics
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or...
US-9,518,086 Crystalline and amorphous forms of a .beta.-arrestin effector
The present disclosure provides novel crystalline forms of a compound that acts as a .beta.-arrestin effector, processes for preparing novel crystalline and...
US-9,518,085 Compounds and pharmaceutical combinations for the treatment of neurodegenerative and ischemic brain diseases
The present invention describes peptides comprising phycocyanobilin (PCB), as well as the medical use of said peptides and that of PCB, due to the...
US-9,518,084 Epitope tag for affinity-based applications
Described is an epitope tag useful in affinity-based applications. The invention further includes fusion proteins, methods for preparing fusion proteins,...
US-9,518,083 Gadd45beta targeting agents
Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use...
US-9,518,082 Antibody purification and purity monitoring
Processes for producing and purifying recombinant proteins are disclosed. In particular, the present disclosure provides processes of producing and purifying...
US-9,518,081 Peptide libraries
The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides...
US-9,518,080 Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate...
US-9,518,079 Effective treatment of tumors and cancer with triciribine and related compounds
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat tumors and cancer by one or a combination...
US-9,518,078 Disaccharide synthetic lipid compounds and uses thereof
Essentially pure compounds of the formulas (I) to (XXV) are provided. Compositions and methods for enhancing or stimulating an immune response are also...
US-9,518,077 Electrochemical synthesis of chloro-chitosan
The present disclosure provides methods for producing chitosan derivatives and the derivatives formed by these methods. The processes of the present disclosure...
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