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Patent # Description
US-9,522,920 Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable...
US-9,522,919 Oxycodone compositions
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
US-9,522,918 Pharmaceutical compositions comprising perillyl alcohol derivatives
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated...
US-9,522,917 Bruton's tyrosine kinase inhibitors for hematopoietic mobilization
Methods to improve hematopoiesis and increase white blood cell counts in subjects and patients using pyrimidine-based inhibitors of Bruton's tyrosine kinase...
US-9,522,916 A.sub.1 adenosine receptor antagonists
This invention relates to compounds of formula (I), Wherein R.sub.1-R.sub.4 are defined in the Specification, their uses in the practice of medicine, their...
US-9,522,915 Method for preparing an important intermediate of linagliptin
The present invention discloses an improved process for preparing an important intermediate of linagliptin. In particular, disclosed are a process for preparing...
US-9,522,914 Azole derivative
The present invention provides agents for treating or preventing diseases such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease,...
US-9,522,913 Pesticidally active bicyclic heterocycles with sulphur containing substituents
Compounds of the formula (I), and the agrochemically acceptable salts and N-oxides of those compounds, including all stereoisomers and tautomeric forms, and...
US-9,522,912 Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): ##STR00001## ...
US-9,522,911 Crystalline forms of tricyclic compound acid salt or hydrate thereof, and method for making thereof
The present invention relates to a novel crystalline acid salt of a tricyclic derivative or a hydrate thereof and a production method thereof. The crystalline...
US-9,522,910 Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical...
The present invention relates to the treatment of oncological, chronic inflammatory and similar diseases with the aid of new families of chemical compounds...
US-9,522,909 Thiazolidinedione derivatives, preparation thereof and use thereof in cancer treatment
The present invention relates to thiazolidinedione derivatives, to the processes for preparing same and to the therapeutic use thereof for preventing or...
US-9,522,908 Ezrin inhibitors and methods of making and using
The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or...
US-9,522,907 Anticancer agent and process for the preparation thereof
The present invention provides a compound of general formula A for use as a potential anticancer agent against human cancer cell lines and a process for the...
US-9,522,906 Tetrahydroquinoline analogues as muscarinic agonists
The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an...
US-9,522,905 Quinazolinone derivatives as PARP inhibitors
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of...
US-9,522,904 Method for producing triazinyl-substituted oxindoles
Process for the preparation of triazinyl-substituted oxindoles of formula (3) ##STR00001## and salts thereof by reacting an oxindole (1) with a triazine (2)...
US-9,522,903 Multifunctional nitroxide derivatives and uses thereof
Multifunctional nitroxide derivatives comprising a potassium channel opener and a reactive oxygen species (ROS) degradation catalyst that can act as an...
US-9,522,902 Uracil derivatives as AXL and c-MET kinase inhibitors
The present application provides compounds of Formula I ##STR00001## or salt forms thereof, wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d, D, W, R.sub.1a,...
US-9,522,901 Compositions and methods including cell death inducers and procaspase activation
Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis...
US-9,522,900 Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with a dialkyl maleate to provide an alkyl...
US-9,522,899 Methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2, 6-dioxopiperidine, and intermediates thereof
The present invention discloses methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2,6-dioxopiperidine and intermediates thereof, namely, the...
US-9,522,898 Oxidation of alcohol compounds via mesostructured VPO catalysts
The present invention concerns a process for the production of an aldehyde compound by an oxidation reaction of an alcohol compound in the presence of a...
US-9,522,897 Method for producing hydride using unsaturated compound having carbon number of 4 as raw material
The present invention relates to a method for producing a hydride having a carbon number of 4, comprising contacting, in liquid phase, an unsaturated compound...
US-9,522,896 Organo-1-oxa-4-azonium cyclohexane compounds
Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems...
US-9,522,895 Organometallic complexes which emit in the red to green spectral region and their use in OLEDs
A triphenylene derivative useful for the production of organic light emitting diodes.
US-9,522,894 Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
The present disclosure relates to certain (2S)--N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable...
US-9,522,893 Therapeutic methods and compounds
The invention provides diketopiperazines of formula I. The invention also provides pharmaceutical compositions comprising the diketopiperazines, or ...
US-9,522,892 Anticoagulant reversal agents
Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods...
US-9,522,891 Pyridazine derivatives and use thereof as medicaments for treating microRNA viral infection
Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising...
US-9,522,890 Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response
The present invention provides a compound, that is ##STR00001## wherein Y, W, Z, R1, R2, R4, R5 and R6 are as defined in the specification. The compounds may...
US-9,522,889 ATX modulating agents
Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds...
US-9,522,888 Substituted bicyclic compounds
Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): ##STR00001## and/or a salt thereof, wherein R.sub.1 is --OH or --OP(O)(OH).sub.2, and...
US-9,522,887 Process for the preparation of dibromohydroxypicolinonitrile
4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and...
US-9,522,886 Pyridine derivatives
The invention relates to a compound of formula (I) wherein R.sup.1 to R.sup.3 are defined as in the description and in the claims. The compound of formula (I)...
US-9,522,885 Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from trifluoroacetylacetic acid
The invention discloses a method for the preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and...
US-9,522,884 Compositions and methods for the treatment of metabolic disorders
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
US-9,522,883 Glycosidase inhibitors and uses thereof
The invention provides compounds of Formula (I) for inhibiting gh cosidases, prodrugs of the compounds, and pharmaceutical compositions comprising the compounds...
US-9,522,882 Strigolactam derivatives as plant growth regulating compounds
The present invention relates to novel strigolactam derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions...
US-9,522,881 Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine...
Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are...
US-9,522,880 Compounds and methods for use in detecting gabapentin
Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce...
US-9,522,879 Method for preparing polythiol compound and polymeric composition for optical material comprising same
The present invention relates to novel methods for preparing a polythiol compound for use in an optical material and polymerizable compositions including a...
US-9,522,878 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use
The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method...
US-9,522,877 Thromboxane receptor antagonists
The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In...
US-9,522,876 Cytotoxic and anti-mitotic compounds, and methods of using the same
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): ##STR00001## including stereoisomers,...
US-9,522,875 Method for treating offgases from a melamine plant
Disclosed is a method for treating or using offgases obtained in a melamine plant comprising at least one melamine synthesis reactor and at least one washing...
US-9,522,874 Lysine-glutamic acid dipeptide derivatives
The invention relates to compounds of the formula I. The compounds of formula I are versatile peptide intermediates for the solid phase peptide synthesis (SPPS)...
US-9,522,873 Biphenyl derivative, pharmaceutically acceptable salt thereof, and methods for preventing or treating...
The present invention relates to a novel biphenyl derivative or a pharmaceutically acceptable salt thereof, a pharmaceutical composition for preventing or...
US-9,522,872 Methods for synthesizing substituted tetracycline compounds
Methods of synthesizing substituted tetracycline compounds are provided.
US-9,522,871 Preparation of (R,R)-fenoterol and (R,R)-or (R,S)-fenoterol analogues and their use in treating congestive...
This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding .beta.2-adrenergic receptors. Exemplary...
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