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Sterilization system for a water-intake finger and air space of a bottle
for a water dispenser
A sterilization system uses an ozone-air mixture for treatment of a water-intake finger and an air space of a water source bottle of a water dispenser in which...
Injectable biodegradable particles
According to an aspect of the invention, injectable polymeric particles are provided that contain a copolymer that contains a hydroxy-acid-based repeat unit...
Diagnostic chewing gum for pathogens
Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal,...
Nucleic acid complexes
The invention relates to nucleic acid complexes, methods of preparation thereof, and uses thereof for delivering a nucleic acid into a cell.
Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and
methods of making and using
Benzodiazepine dimers having a structure represented by ##STR00001## wherein X comprises a heteroaromatic moiety and is as further defined in the application;...
Cancer-related extracellular matrix signatures and related methods and
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix...
Low density lipoprotein receptor-mediated siRNA delivery
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in...
Pyrrolobenzodiazepines and targeted conjugates
A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R.sup.10...
Combination IL-2 immunoconjugate therapy
The present invention provides combinations of (a) an immunoconjugate comprising a first antibody engineered to have reduced effector function and an effector...
Peptide-based in vivo siRNA delivery system
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi...
N-BOC-dendrimers and their conjugates
Asymmetrical dendritic compound of the Formula (I) as described herein can contain multiple functional moieties as represented by R.sup.1 and R.sup.2 in Formula...
Injectable dendrimer hydrogel nanoparticles
The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 .mu.m, comprising PAMAM...
Salts of phenylethylamines and inorganic acids and methods of use thereof
Disclosed are salts of 2-phenylethylamines and deprotonated inorganic acids, compositions and formulations containing the same, and methods of making and using...
Composition and method for producing an edible base product
A composition and method for producing an edible base product, the composition comprising a cannabis concentrate containing at least one cannabinoid, a starch...
Weakly acidic pH-responsive peptide and liposome containing same
A problem to be solved by the present invention is to provide a peptide compound for producing a drug delivery carrier capable of releasing a target substance...
Pharmaceutical aerosol compositions comprising fluticasone
The present invention relates to pharmaceutical compositions and in particular to suspension aerosol pharmaceutical compositions, processes to obtain them and...
Highly robust fast-disintegrating tablet and process for manufacturing the
Disclosed are an oral formulation which disintegrates quickly in the oral cavity; a fast-disintegrating tablet having fast disintegrability and high hardness,...
Pharmaceutical lipid compositions
The present invention relates to a particulate composition containing; a) 5 to 90% of at least one phosphatidyl choline component b) 5 to 90% of at least one...
Sustained-release lipid pre-concentrate of pharmacologically active
substance and pharmaceutical composition...
Disclosed is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more...
Thermostabilization of proteins
Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a...
Pharmaceuticals for oral delivery
The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical...
Delivery system for functional nucleases
Compositions, methods, strategies, kits, and systems for the supercharged protein-mediated delivery of functional effector proteins into cells in vivo, ex vivo,...
Spray composition for treating and preventing diaper rash
A composition for treating and preventing diaper rash comprises zinc oxide, dimethicone, mineral oil, a suspending agent, and an emulsifier. The emulsifier has...
Pharmaceutical compositions comprising inhibitors of zinc-ZIP8-MTF1 as
active ingredients for preventing or...
The present invention relates to identification of Zinc-ZIP8-MTF1 axis that plays an important role to OA (osteoarthritis) pathogenesis process and a novel use...
Pharmaceutical formulations and the use thereof for the treatment of
The present invention relates to compositions which can be used in immunotherapy and especially to compositions which can be used in immunotherapy for mammals,...
Liquid stable virus vaccines
The present invention discloses liquid stable vaccines that comprise a live attenuated virus, 10-30% sugar additive, and an amino acid. The present invention...
Method for cancer immunotherapy and pharmaceutical compositions based on
oncolytic non-pathogenic Sendai virus
The invention relates to the field of immunology and medicine, more specifically, oncology, and can be useful for the treatment of patients with carcinomas and...
Influenza vaccine, composition, and methods of use
The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In...
Methods for the induction of ebola virus-specific immune responses
comprising administering a...
This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In...
Combination vaccines with serogroup B meningococcus and D/T/P
Serogroup B meningococcus antigens can successfully be combined with diphtheria, tetanus and pertussis toxoids ("DTP") to provide effective combination vaccines...
Glycoengineered outer membrane vesicles and use thereof as vaccines
The present application relates to glycoengineered outer membrane vesicles obtained from recombinant, gram-negative bacteria comprising hetereologous DNA...
Methods and compositions for suppressing virulence of methicillin
resistant Staphylococcus aureus
The present invention is directed to methods of suppressing the virulence of one or more virulence antigenic factors of methicillin resistant Staphylococcus...
M. tuberculosis vaccines
The present invention is directed to fusion proteins, antigen cocktails and immunological compositions such as vaccines against infections caused by virulent...
Ehrlichial invasin for immunization, diagnosis, and cell delivery
Disclosed are vaccines containing one or more immunogenic polypeptides derived from an EtpE protein from an Ehrlichia sp. or nucleic acid encoding these...
Antigen composition, preparation method and use thereof, and tumor vaccine
The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor...
Methods of modulating bone remodeling
Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an...
Macrocylic oximyl hepatitis C protease inhibitors
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit serine...
Compositions for the treatment of cancer
The present invention relates to novel compositions comprising proteolytic enzymes and fining agents as well as methods for the treatment and/or prevention of...
Pharmaceutical composition comprising bee venom-phospholipase A2 (BV-PLA2)
for treating or preventing diseases...
The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity...
Potentiation of antibiotic treatment with a protein-lipid complex
Provided are compositions and methods for potentiating the effect of antibiotics. The compositions comprise a non-covalent complex of alpha-lactalbumin and...
Delivery of therapeutic agents by a collagen binding protein
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic...
Combination of an insulin and a GLP-1-agonist
The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.
Solvent/polymer solutions as suspension vehicles
A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at...
Multidomain peptides for promoting angiogenesis
The present disclosure provides a composition comprising a multi-domain peptide capable of self-assembly into a nanofibrous hydrogel structure capable of...
Dried reconstituted vesicle formation for pharmaceutical application
The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic...
LEDGF peptides and formulations thereof for treatment of degenerative
LEDGF peptides with anti-protein aggregation activity and methods of use are provided. The LEDGF peptides disclosed herein demonstrate an ability to treat...
Activin-actriia antagonists and uses for treating or preventing breast
In certain aspects, the present invention provides compositions and methods for treating or preventing breast cancer in humans.
Administration of angiocidin for arresting the growth of a tumor cell
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also...
Peptides that inhibit the interaction between ASF1 and histones, and use
The present invention relates to peptides capable of inhibiting the formation of the complex between the Asf1 histone chaperone and histones H3-H4, and to the...
Chemical induction of lactation in male non-human mammals
The present invention describes a method of inducing lactation in non-human mammals by using a single administrations of an estrogen compound, a dopaminergic...