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Treating basal-like genotype cancers
Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods...
Monospecific and bispecific anti-IGF-1R and anti-ErbB3 antibodies
Provided are monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3....
Humanized pan-HER antibody compositions
The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one...
Prevention of immunological rejection of transplanted stem cells by
leukocyte costimulatory molecule blockade
Compositions and methods are provided for transplantation of pluripotent stem cells and differentiated cells derived therefrom.
Ang-2 specific antibodies and uses thereof
Provided are an anti-Ang-2 antibody or antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang-2),...
Antibodies to tau and uses thereof
Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of...
Modified variable domain molecules and methods for producing them
The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (V.sub.L) which...
Antigens associated with endometriosis, psoriatic arthritis and psoriasis
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or...
Immunotherapies employing self-assembling vaccines
Provided herein are self-assembling pharmaceutical compositions comprising a heat shock protein fused to a biotin-binding protein, wherein the biotin-binding...
Antibodies that specifically bind Staphylococcus aureus alpha toxin and
methods of use
Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.
Delivery of proteins using adeno-associated virus (AAV) vectors
Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
Engineered antibody constant domain molecules
Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at...
Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody...
Recombinant bi-functional fusion proteins, preparations and methods for
A recombinant bi-functional fusion protein, comprising an Ig region of an extracellular domain of a signal-regulator protein (SIRP), linked via a Fc fragment of...
Double-acylated GLP-1 derivatives
The invention relates to a derivative of a GLP-1 analog, which analog comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ...
Recombinant human follicle-stimulating hormone
The present invention pertains to improved FSH preparations which are capable of stimulating sex steroid release at much lower concentration than the commonly...
Oxyntomodulin derivatives and pharmaceutical composition for treating
obesity comprising the same
The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native...
CD40L collectin fusion proteins and encoding nucleic acid molecules
The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin...
Stabilized p53 peptides and uses thereof
Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying...
CAPCNA peptide therapeutics for cancer
Administration of compositions comprising cell-permeable cancer-specific proliferating cell nuclear antigen derived peptides and their variants reduces the...
Polymutant tau protein variants and their use for recapitulating human
Disclosed herein are methods for identifying an agent for treating or preventing neurogenerative disease and to methods for recapitulating tauopathies using a...
Methods and uses of a modified cecropin for treating endoparasitic and
The present disclosure provides a modified cecropin protein comprising a cecropin or a variant thereof fused to a hydrophilic tail lacking a C-terminal glycine....
Protective vaccine based on Staphylococcus aureus SA2451 protein
The present invention relates to methods of inducing an immune response to Staphylococcus comprising administering a composition comprising an SA2451-related...
Immunoadjuvant flagellin-based compounds and use thereof
The present invention relates to novel peptide compounds derived from flagellin originating from Salmonella enterica that exhibit an in vivo immune adjuvant...
FC receptor (FcRn) binding peptides and uses thereof
The invention provided herein includes isolated polypeptides that specifically block the interaction between neonatal Fc receptor (FcRn) and albumin. Blocking...
RFamide-related peptides and methods thereof
Provided herein methods and compositions directed to RFRP-1 polypeptides for modulating cardiac contractile function, for preventing and/or treating cardiac...
Anti-inflammatory peptides and composition comprising the same
A peptide with anti-inflammatory activity is described, wherein the peptide comprises at least one amino acid sequence among SEQ ID NO: 2 to SEQ ID NO: 179, the...
Treatments for gastrointestinal disorders
The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and...
Amphipathic peptide-lipase conjugate having advanced lipase activity and
Disclosed are an amphipathic peptide-lipase conjugate with enhanced lipase activity, a polynucleotide coding for the conjugate, an expression vector carrying...
Hepatitis C virus inhibitors
Hepatitis C virus inhibitors having the general formula (I) ##STR00001## are disclosed. Compositions comprising the compounds and methods for using the...
Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast
activation protein and methods of use
The presently disclosed and claimed inventive concepts include inhibitors of antiplasmin cleaving enzyme (APCE) and fibroblast activation protein alpha (FAP)...
Methods for the synthesis of ceragenins
Disclosed herein are methods of making ceragenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial...
Triterpenoids with HIV maturation inhibitory activity
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that...
Steroid analogues for neuroprotection
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water...
Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
Aster glehni extracts, fractions or compounds isolated therefrom for the
treatment or prevention of...
The present invention relates to an Aster glehni extract, a fraction thereof and the active compounds isolated therefrom, which are effective for the treatment,...
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to
modulate lipid metabolism
The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with...
Metal complexes, their application and methods of carrying out of
This disclosure relates to new metal complexes, such as compounds of Formula 1, and their application in olefin or alkyne metathesis and to methods of carrying...
Prodrugs of bicyclic substituted pyrimidine type PDE-5 inhibitors
Provided are prodrugs of a bicyclic substituted pyrimidine type PDE-5 inhibitors, pharmaceutically acceptable salts or stereoisomers thereof. Also provided are...
Antidiabetic tricyclic compounds
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
Process for surface modification of particulate solids
Improved utilization of organosilicon compounds in hydrophobicizing finely divided particulate solids is accomplished by metering a partial amount of unreacted...
Urea-containing silanes, process for preparation thereof and use thereof
The invention relates to urea-containing silanes of the formula I ##STR00001## which are prepared by reacting urea-containing disulphide silanes of the formula...
Hybrid zeolitic imidazolate frameworks: controlling framework porosity and
functionality by a mixed-ligand...
Metal-organic frameworks, in particular hybrid zeolitic imidazolate frameworks (ZIFs), devices having hybrid ZIFs, and methods for preparing hybrid ZIFs are...
Benzodiazepine dimers, conjugates thereof, and methods of making and using
Benzodiazepine dimers having a structure represented by ##STR00001## wherein R.sup.1 is ##STR00002## wherein the variables in formulae (I), (Ia), and (Ib)...
Liquid crystal compound, liquid crystal composition and liquid crystal
To provide a liquid crystal compound satisfying at least one physical property such as high stability to light, a high clearing point, low minimum temperature...
Indolizine derivatives as phoshoinositide 3-kinases inhibitors
Compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with PI3K enzymes.
Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.
Antibacterial biaromatic derivatives
The invention relates to antibacterial compounds of formula I and salts thereof and methods of treating bacterial infection using the compounds. ##STR00001##
Processes for production of intermediates for 2-alkyl cephem compounds
The invention relates to processes for the production of intermediates for preparing 2-alkyl cephem compounds useful as antimicrobial drugs. The invention...
Quinazoline analogs as receptor tyrosine kinase inhibitors
This invention provides quinazoline analogs of Formula I: ##STR00001## where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the...