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Patent # Description
US-9,534,063 Procatalyst composition with substituted 1,2-phenylene aromatic diester internal donor and method
Disclosed are procatalyst compositions having an internal electron donor which include a substituted phenylene aromatic diester and optionally an electron donor...
US-9,534,062 Synthesis of an acrylate polymer in flow reactor
An improved process for synthesizing acrylic polymers, which is highly controllable to achieve high molecular weight, high conversion rate, and low...
US-9,534,061 Methods for preparing alkali cellulose and cellulose ether
The invention is an efficient method for preparing alkali cellulose having the low water content and a uniform alkali distribution therein. More specifically,...
US-9,534,060 Carrier for antibody purification, manufacturing method for same, and application for same
An object of the present invention is to provide a carrier on which Protein A has been immobilized, the Protein A having a specific amino acid sequence that...
US-9,534,059 TIKI inhibitors
Modulators of Wnt activity, e.g., Wnt inhibitors, that act on TIKI proteins and inhibit TIKI-mediated cleavage of Wnt proteins, as well as methods of...
US-9,534,058 Anti-CD324 monoclonal antibodies and uses thereof
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
US-9,534,057 Methods of treating tumors with engineered antibody-interferon mutant fusion molecules
The field of the present invention relates to genetically engineered fusion molecules, methods of making said fusion molecules, and uses thereof in anti-tumor...
US-9,534,056 Engineered TAA antibody-TNFSF member ligand fusion molecules
The field of the present invention relates to genetically engineered fusion molecules, methods of making said fusion molecules, and uses thereof in anti-tumor...
US-9,534,055 Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone...
The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and...
US-9,534,054 Monoclonal antibody directed against CXCR5
The invention relates to monoclonal antibodies against human CXCR5 and to their use in the treatment of autoimmune or inflammatory diseases, as well as cancers.
US-9,534,053 Therapeutic human anti-IL-1R1 monoclonal antibody
Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a ...
US-9,534,052 Reducing systemic regulatory T cell levels or activity for treatment of Alzheimer's disease
A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a...
US-9,534,051 Immunoregulation by anti-ILT5 antibodies and ILT5-binding antibody fragments
Disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof for the treatment of various diseases and for use as...
US-9,534,050 Antibodies to tumor endothelial marker 7R
Antibodies that specifically bind to an epitope on the extracellular domain of TEM7R are provided. Nucleic acids encoding such antibodies and cells capable of...
US-9,534,049 Neutralizing antibodies and methods of use thereof
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the...
US-9,534,048 Antibodies to TTR and methods of use
The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides,...
US-9,534,047 Methods of treating Kawasaki disease using IL-1beta antibodies
This invention relates to a novel use of IL-1.beta.-ligand/IL-1 receptor disrupting compounds (herein referred to as "IL-1beta Compounds"); such as small...
US-9,534,046 Antibodies to TNF.alpha.
Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNF.alpha.); nucleic...
US-9,534,045 Phoenixin peptides
Human phoenixin peptides, analogs and mimetics useful in production of anti-phoenixin antibodies, diagnostic screening and assays, and in modulating cellular...
US-9,534,044 Alpha-synuclein antibodies and uses thereof
The invention describes antibodies having a high affinity for aggregated forms of .alpha.-synuclein and a low affinity for monomeric forms of .alpha.-synuclein....
US-9,534,043 Anti-serum albumin binding variants
The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates...
US-9,534,042 Influenza virus-neutralizing antibody and screening method therefor
Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according...
US-9,534,041 Monoclonal antibodies that neutralize a norovirus
Monoclonal neutralizing antibodies are disclosed that specifically bind to a Norovirus. In some embodiments, the Norovirus is a genogroup II Norovirus or a...
US-9,534,040 Antiviral agent against animal viruses
Provided is an antiviral agent against animal viruses. The antiviral agent contains a protein or a nucleic acid sequence encoding the protein, as an active...
US-9,534,039 Method for the production of immunoglobulin single variable domains
Methods are provided for the expression of immunoglobulin variable domains that are secreted into the culture medium. The methods provide for the production of...
US-9,534,038 Isolated laminin-421
The present disclosure provides isolated laminin-421, methods for making recombinant laminin-421, and host cells that express recombinant laminin-421. The...
US-9,534,037 Systems and methods to increase protein yield from recombinant manufacturing processes
Embodiments disclosed herein provide systems and methods that increase protein yield from recombinant manufacturing processes. The systems and methods treat...
US-9,534,036 Detection of platelet-derived shed CD31
The present invention relates to various soluble forms of CD31, including a novel form which is shed by activated platelets and released into the circulation....
US-9,534,035 Cell lines expressing ENaC and methods using them
Cell lines that stably express ENaC and methods for using those cell lines are disclosed herein. The invention includes cell lines that express various subunit...
US-9,534,034 Methods of modulating apoptosis by administration of relaxin agonists or antagonists
The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding...
US-9,534,033 Targeted interferons demonstrating potent apoptotic and anti-tumor activities
Novel chimeric moieties that show significant efficacy against cancers are provided. In certain embodiments the chimeric moieties comprise a targeting moiety...
US-9,534,032 Thrombopoietic compounds
The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the...
US-9,534,030 Survivin-derived peptides and uses thereof
MHC Class I-restricted peptides derived from the tumor associated antigen, survivin, which peptides are capable of binding to Class I HLA molecules at a high...
US-9,534,029 Method of purifying proteins
The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying...
US-9,534,028 Method for the preparation of a serum protein concentrate
The present invention relates to a method for the preparation of a concentrate of serum proteins with reduced lactose content from a sample of lactoserum,...
US-9,534,027 Mutant NGAL proteins and uses thereof
In one aspect the present invention is directed to mutant Neutrophil Gelatinase Associated Lipocalin (NGAL) proteins that have the ability to bind to...
US-9,534,026 Corn active peptide additive for cell culture medium
The present invention provides a corn active peptide additive for cell culture medium, wherein in the corn active peptide additive, oligopeptides with molecular...
US-9,534,025 Method for inducing resistance to stress caused by pathogens in plants
Polypeptide having activity inducing pathogen plant defence, nucleotide sequence encodes it, microorganism, compositions and methods. The polypeptide is a...
US-9,534,024 Msp nanopores and related methods
Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such...
US-9,534,023 Mutated immunoglobulin-binding protein
The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than...
US-9,534,022 Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus
Disclosed are novel immunogenic proteins derived from Staphylococcus aureus, as well as methods for their use in conferring protective immunity against S....
US-9,534,021 Lyme disease vaccine
Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are...
US-9,534,020 Immunogenic polypeptides comprising a modified loop peptide presenting the HIV-1 GP120 3074 mAb epitope and...
The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold...
US-9,534,019 Peptides with antimicrobial activity, drug compositions for the treatment and prophylaxis of animals,...
The present invention provides methods of preparing extracts of material fermented with Paenibacillus sp., preferably Paenibacillus elgii ourofinensis. The...
US-9,534,018 Melanocortin analogs having enhanced activity and transport
Described herein are melanocortin analogs having enhanced activity and transport.
US-9,534,017 Beta-arrestin effectors and compositions and methods of use thereof
This application describes a family of compounds acting as .beta.-arrestin effectors. Such compounds may provide significant therapeutic benefit in the...
US-9,534,016 Netrin loop peptide mimetics and uses thereof
In certain embodiments compositions are provided that comprise a pentapeptide comprising the formula: C.sup.1-X.sup.2-X.sup.3-X.sup.4-C.sup.5 where C.sup.1 and...
US-9,534,015 Pro-pigmenting peptides
The invention is directed to the use of at least one peptide of formula: X-(Xaa.sub.1).sub.n-Pro*-(Xaa.sub.2).sub.m-Y (I) With: -n=0, or 2; -m=0 or 1 and if m=0...
US-9,534,014 Pharmaceutical compositions with attenuated release of phenolic opioids
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides...
US-9,534,013 Purification of proteins with cationic surfactant
The subject invention provides a method for purifying a target protein from a mixture comprising the target protein and contaminating protein, comprising the...
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