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Patent # Description
US-9,534,012 Affinity substrate and methods for selectively purifying a blood plasma protein
An affinity substrate for the selective binding of a protein of blood plasma includes a solid substrate material on which are immobilized deoxyribonucleic...
US-9,534,011 Apparatus and method for solid phase synthesis
An apparatus for microwave assisted solid phase synthesis using solid-phase resin beads mixed with a liquid solvent comprising a generally cylindrical reactor...
US-9,534,010 Stable indole-3-propionate salts of S-adenosyl-L-methionine
Stable indole-3-propionic acid salts of S-adenosyl-L-methionine, or a pharmaceutically acceptable salt thereof, are disclosed, as well as pharmaceutical...
US-9,534,009 Pan-selectin inhibitor with enhanced pharmacokinetic activity
Compounds, compositions and methods are provided for treatment of diseases or complications associated therewith, in which a selectin plays a role. More...
US-9,534,008 Small molecule compounds that control plant- and insect-pathogenic nematodes
The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or...
US-9,534,007 Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity
A composition and method for treating excess cyanide and hydrogen sulfide comprising administering a cobinamide. Further a method for determining extent of...
US-9,534,006 Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device
As a novel substance having a novel skeleton, an organometallic complex with high emission efficiency which achieves improved color purity by a reduction of...
US-9,534,005 Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device
A novel organometallic complex which can emit phosphorescence is provided. A light-emitting element, a light-emitting device, an electronic device, or a...
US-9,534,004 Crystalline forms of ceftaroline fosamil
The present invention relates to novel crystalline forms of ceftaroline fosamil and to methods for their preparation. Furthermore the present invention relates...
US-9,534,003 Protected linker compounds
The invention features protected linker compounds which comprise at one terminus a protected amino group and at another other terminus a phosphorous activating...
US-9,534,002 Procedures for the synthesis of ethylenediamine bisborane and ammonia borane
A method for synthesizing ammonia borane includes (a) preparing a reaction mixture in one or more solvents, the reaction mixture containing sodium borohydride,...
US-9,534,001 Organomagnesium synthesis agent
An organomagnesium synthesis agent, a process for preparing this synthesis agent, and its use.
US-9,534,000 Cytotoxic benzodiazepine derivatives and methods of preparation
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds, such as those...
US-9,533,999 Fused thiazin-3-ones as KCA3.1 inhibitors
The present invention encompasses compounds of the formulas (I) & (II), wherein the groups A, L and Ar are defined as in claim 1, which are suitable for the...
US-9,533,998 Carbazole dioxazine pigments
The present disclosure relates to a benzoyl substituted carbazole-dioxazine pigment and its preparation. The process involves benzoylation of...
US-9,533,997 Tricyclic heterocycles as BET protein inhibitors
The present invention relates to tricyclic heterocycles of Formula (I), which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful...
US-9,533,996 Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones
Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and...
US-9,533,995 Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
The present disclosure relates to a series of substituted N-heteroaryl spirolactam bipyrrolidines of formula (I). ##STR00001## Wherein R.sub.1, R.sub.2,...
US-9,533,994 Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
A monoclinic crystalline form of asenapine maleate is described, which is characterized in that it is not micronised and has a particle size distribution...
US-9,533,993 Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and...
The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone...
US-9,533,992 PDE9 inhibitors with imidazo triazinone backbone
This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically...
US-9,533,991 Inhibitors of Bruton's tyrosine kinase
Disclosed herein are amido compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Also...
US-9,533,990 Inhibitors of secretion of hepatitis B virus antigens
Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.
US-9,533,989 Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors
The present invention relates to compounds of formula (Ia), (Ib) or (Ic): ##STR00001## to pharmaceutically acceptable salts therefore and to pharmaceutically...
US-9,533,988 Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR00001## a method for manufacturing said compound,...
US-9,533,987 Heterocyclic derivates
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
US-9,533,986 Bicyclic dihydropyridone kinase inhibitors
Provided are bicyclic dihydropyridone compounds for inhibiting of JAK/Syk kinase, intermediates used in making such compounds, methods for their preparation,...
US-9,533,985 Sulfonamide derivative and medicinal use thereof
Sulfonamide compounds of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a...
US-9,533,984 Bicyclic heterocycles as FGFR inhibitors
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are...
US-9,533,983 Antiplatelet agent
The present invention relates to a novel antiplatelet agent and a novel compound which is an active ingredient for the agent. The present invention provides the...
US-9,533,982 Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds;...
US-9,533,981 Pyridine derivatives
The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing...
US-9,533,980 NOL3 is a predictor of patient outcome
The present invention features a method for determining the prognosis for survival of a cancer patient. Methods for measuring the level of NOL3 expression in a...
US-9,533,979 Amino-derivatives as novel inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, m, t, R.sup.1, R.sup.2, L, Q, X, Y, Z and ##STR00002## have defined...
US-9,533,978 Pyrimidine derivatives and their use in the treatment of cancer and further diseases
The invention concerns compounds of Formula (I): wherein L.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X are as defined in the description. The present...
US-9,533,977 Oxazolidinone derivative as CETP inhibitor, its preparation method, and pharmaceutical composition comprising...
Disclosed are a novel oxazolidinone derivative exhibiting inhibitory activity against CETP, a preparation method thereof, and a pharmaceutical composition...
US-9,533,976 .gamma.-diketones as WNT/.beta.-catenin signaling pathway activators
The present disclosure provides .gamma.-diketones or analogs thereof, that activate Wnt/.beta.-catenin signaling and thus treat or prevent diseases related to...
US-9,533,975 Dual-action, unnatural proline-rich peptides as antibiotic agents and methods thereof
The present invention cationic amphiphilic polyproline helices (CAPHs) compounds having increased hydrophobicity and cellular internalization as antimicrobial...
US-9,533,974 Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new...
US-9,533,973 Allosteric modulators of 5-hydroxytryptamine 2C receptor (5-HT2CR)
The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same....
US-9,533,972 Substituted sodium-1H-pyrazole-5-olate
The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol- -5-olate, to processes for its preparation,...
US-9,533,971 Process for the synthesis of dabigatran and its intermediates
The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the...
US-9,533,970 Multisubstituted aromatic compounds as serine protease inhibitors
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or...
US-9,533,969 Materials and method for inhibiting replication protein A and uses thereof
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer...
US-9,533,968 N-thio-anthranilamide compounds and their use as pesticides
The present invention relates to N-thioanthranilamide compounds of formula (I), and the stereoisomers, N-oxides and agriculturally or veterinarily acceptable...
US-9,533,967 Multisubstituted aromatic compounds as inhibitors of thrombin
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or...
US-9,533,966 Cyclic compounds
The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of...
US-9,533,965 2-arylbenzofuran-7-formamide compounds, preparation method and use thereof
Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable...
US-9,533,964 Piperazine substituted bridged spiro[2.4]heptane derivatives as ALX receptor agonists
The present invention relates to a piperazine substituted bridged spiro[2.4]heptane derivative of formula (I), ##STR00001## its preparation and its use as...
US-9,533,963 Alkylamidothiazoles, cosmetic or dermatological preparations containing said alkylamidothiazoles, and use...
Alkylamidothiazoles of general formula (I), wherein R 1=--C1-C24 alkyl (linear and branched), --C1-C24 alkenyl (linear and branched), --C1-C8 cycloalkyl,...
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