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Mutated T7 RNA Polymerases
The present invention pertains to a mutated T7 RNA polymerase and its use, the T7 RNA polymerase being mutated at position 744, the glutamine (Q) being replaced...
Trichoderma reesei glucoamylase variants resistant to oxidation-related
activity loss and the use thereof
Embodiments of the present disclosure relate to Trichoderma reesei glucoamylase (TrGA) variants having improved properties (e.g., improved thermostability,...
Reduced sugar syrups and methods of making reduced sugar syrups
A reduced sugar syrup having an advantageously low viscosity is prepared by hydrolysis of starch or starchy material using a particular type of alpha amylase...
Methods of biosynthesizing bacterial extracellular galactomannan
polysaccharides and subunits thereof for use...
Methods of biosynthesizing bacterial extracellular galactomannan polysaccharides for use in subterranean formation operations such as drilling operations,...
Polyunsaturated fatty acid synthase nucleic acid molecules and
polypeptides, compositions, and methods of...
The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in...
Process for producing ethanol from textile cotton
A recycled textile cotton used for producing ethanol by the execution of a process that includes a step of pretreatment of textile cotton by pulping in an...
Systems and methods for improving ethanol yield
Systems and methods for improving ethanol yield are provided. A feedstock is ground suitably fine for use in fermentation. The feedstock may include corn or any...
The object of the present invention is to provide a microorganism capable of maintaining its xylose fermentation ability over a long period of time. The present...
Methods and compositions for producing squalene using yeast
Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted...
Method for the complete anaerobic digestion of polymer mixtures
The present invention relates to a process for complete anaerobic digestion of polymer mixtures of the composition: a) 25 to 95% by weight of a...
Vector comprising multiple homologous nucleotide sequences
The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting...
Modified adeno-associated virus vector compositions
An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.
This invention relates to an adenovirus vector having excellent gene transfection activity on specific cell lines, particularly on hematopoietic cells. This...
Expression of secreted and cell-surface polypeptides
Some embodiments herein provide compositions and methods for expressing secreted and cell-surface-bound polypeptides in a single cell. In some embodiments,...
Stacked herbicide tolerance event 8218.104.22.168, related transgenic soybean
lines, and detection thereof
This invention relates to soybean event pDAB8222.214.171.124, which includes a novel expression cassette comprising multiple traits conferring resistance to...
Stacked herbicide tolerance event 8264.44.06.1, related transgenic soybean
lines, and detection thereof
This invention relates in part to soybean event pDAB8264.44.06.1 and includes a novel expression cassettes and transgenic inserts comprising multiple traits...
Synthetic brassica-derived chloroplast transit peptides
This disclosure concerns compositions and methods for targeting peptides, polypeptides, and proteins to plastids of plastid-containing cells. In some...
Light-inducible promoter and gene expression system containing same
The present invention relates to a light-inducible promoter and a gene expression system containing the same, and provides: a light-inducible promoter...
Metabolic engineering of the shikimate pathway
The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to...
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like
receptor based immune response
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that...
Nucleic acid fragment binding to target protein
An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a DNA aptamer, having...
Method for opening tight junctions
The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of...
Therapeutic use of activators of zinc finger protein GL13
The present invention relates to the therapeutic use of activators of the zinc finger protein GLI3 in diseases that are associated with reduced Hedgehog...
Methods and compositions for the treatment of cancer
Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for...
Cellular targets for HIV infection
Methods and compositions are provided for treating HIV infection and for inhibiting HIV infection, and for identifying purinergic receptor antagonists or Panx 1...
Compositions and methods related to miRNA modulation of neovascularization
The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases...
Small interference RNA for inhibiting intracellular expression of
ribosomal protein S3
The present invention relates to a small interference RNA (siRNA) for specifically inhibiting the expression of ribosomal protein in cells, and more...
Organic compositions to treat HSF1-related diseases
The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically...
Compositions and methods for controlling arthropod parasite and pest
This application provides and discloses anti-parasitic, anti-pest or insecticidal nucleic acid molecules and their calmodulin target genes for the control of...
In certain embodiments, methods, compounds, and compositions for treating B-cell lymphoma or hepatocellular carcinoma by inhibiting expression of STAT3 mRNA or...
Compositions and methods for inhibiting hypdxia induced damage
Provided are compositions and methods for inhibiting hypoxia-induced damage. The compositions and methods involve the use of one or more agents that can inhibit...
Tetragalnac containing conjugates and methods for delivery of
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or...
Lipid particle, nucleic acid transfer carrier, compound for manufacturing
nucleic acid transfer carrier, method...
The present invention provides a lipid particle which has low cytotoxicity, can stably hold a nucleic acid molecule outside a cell (in blood), and can escape...
Nucleic acid adaptors and uses thereof
Provided herein are compositions, systems, methods, and kits for joining together the ends of one or more polynucleotides using at least one pair of blocking...
Method and materials for isolation of nucleic acid materials
A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a...
Buffer for one-step DNA extraction
DNA is extracted from epithelial cells and other cells without cell walls, by use of a DNA extraction buffer that contains a C.sub.1-C.sub.4 alcohol, a cell...
Transcriptome in vivo analysis
Provided are compositions and methods that permit a hybrid nucleic acid-peptide molecule to enter a cell and when specifically activated within the cell, the...
High expression cereal phytase gene
The present invention provides mutant cereal plants and mature grain thereof, characterised by enhanced levels of the enzyme phytase in the grain, and methods...
Method and device for plankton separation
Methods, devices and kits for the physical separation of plankton into its component parts utilizing phototactic behavior are described. The methods utilize...
Immobilized glucose oxidase for use in oral hygiene
Compositions are provided to immobilize and protect oxidase enzymes from proteolytic and hydrolytic attack, utilizing a porous, inert organic, or inorganic,...
Optimization of alginate encapsulation of islets for transplantation
Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a...
Innovative discovery of therapeutic, diagnostic, and antibody compositions
related to protein fragments of...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof,...
Aminoacyl tRNA synthetases for modulating inflammation
Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments...
Methods and compositions for isolating, identifying and characterizing
monocot plastidic accase herbicide...
The present invention relates compositions and methods for identifying, isolating, and characterizing herbicide tolerant mutations in monocot plastidic...
Regulator of complement activation and uses thereof
A potent complement regulator is disclosed. The complement regulator comprises a complement regulatory region connected by a flexible linker to a...
Human carbonic anhydrase II with increased physical stability
An isolated polypeptide having carbonic anhydrase activity, the sequence of which corresponds to modified human carbonic anhydrase II is described. The isolated...
Glucoamylase variants and polynucleotides encoding same
The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the...
Method for increasing the efficiency of double-strand-break induced
The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new...
Engineered biocatalysts useful for carbapenem synthesis
The present disclosure provides engineered pNB esterase polypeptides useful for the synthesis of the carbapenem antibiotic, imipenem. The disclosure also...
NPP1 fusion proteins
The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion...