At Patents you can conduct a Patent Search, File a Patent Application, find a Patent Attorney, or search available technology through our Patent Exchange. Patents are available using simple keyword or date criteria. If you are looking to hire a patent attorney, you've come to the right place. Protect your idea and hire a patent lawyer.
A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an...
Anti-inflammatory peptides and composition comprising the same
A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned...
Polypeptide specifically binding to rare earth nanoparticles and use
The present invention provides a polypeptide able to specifically bind to rare-earth nanoparticles and the use thereof. The polypeptide comprises an amino acid...
Compositions and methods for treating ischemia and ischemia-reperfusion
The present invention relates to compositions comprising a substantially pure compound represented by Structural Formula I: ##STR00001## and methods of using...
The present disclosure concerns methods for producing purified saponins, such as QS-21, which reduces the number of necessary lyophilization cycles to one by a...
Inhibitors of the farnesoid X receptor and uses in medicine
Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R.sup.1, R.sup.2, R.sup.4, X, Y, Z, m, and n are as defined herein,...
TGR5 modulators and methods of use thereof
The invention relates to compounds of Formula A: ##STR00001## or a salt, solvate, or hydrate thereof. The compounds of formula A are TGR5 modulators useful...
Method for monofluoromethylation of organic substrates to prepare
biologically active organic compounds
Described herein is a process for the preparation of monofluoromethylated organic biologically active compounds using monofluoromethylated reagents. Fluticasone...
Methods of preparing targeted aptamer prodrugs
The present invention provides methods of preparing an oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells, the...
HCV polymerase inhibitors
The invention provides compounds of the formula: ##STR00001## wherein B is a nucleobase selected from the groups (a) to (d): ##STR00002## and the other...
Gemcitabine prodrugs and uses thereof
The present invention provides compounds according to formula I: ##STR00001## and pharmaceutically acceptable salts thereof. For compounds of formula I,...
Synthetic amphiphiles for membrane protein manipulation
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas...
Cobalt precursors for low temperature ALD or CVD of cobalt-based thin
Cobalt silylamide and cobalt carbonyl precursors are described, which are usefully employed in vapor deposition processes, such as chemical vapor deposition and...
Phospholipid drug analogs
Provided in some embodiments are compositions comprising a compound having a structure according to Formula A or Formula B: ##STR00001## or a pharmaceutically...
Process for fosaprepitant
The present invention provides a novel process for reducing palladium content in fosaprepitant dimeglumine.
Diaminophenothiazinium derivatives for labelling biomolecules, method and
substrate for labelling...
The present invention relates to diaminophenothiazinium derivatives of formula (I); in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and X.sup.-...
Fluorinated ether compound, fluorinated ether composition and coating
liquid, and substrate having...
To provide a fluorinated ether compound, a fluorinated ether composition and a coating liquid, whereby it is possible to form a surface-treated layer which has...
Bonding method, bondability improving agent, surface modification method,
surface modifying agent, and novel...
To provide a technique by which an --OH group can be effectively formed on a material surface for the purpose of making the material suitable for bonding (for...
Covalent tethering of functional groups to proteins
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the...
Method for producing alkyl-indium compounds and the use thereof
The invention relates to a method for the cost-effective and environmentally friendly production of dialkyl indium chloride in high yield and with high...
Compounds as diacylglycerol acyltransferase inhibitors
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions...
The invention relates to antibacterial compounds of formula I ##STR00001## wherein R.sup.1, U, V and A are as defined in the description, to pharmaceutical...
therapeutic uses thereof
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
6-arylamino pyridone carboxamide as MEK inhibitors
The invention provides novel substituted 6-arylamino pyridone carboxamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, poly-morph,...
Histone deacetylase inhibitors
This invention relates to generally inhibiting histone deacetylase (HDAC) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
Compounds and methods for treating bacterial infections
Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed. ...
Inhibitors of human immunodeficiency virus replication
The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said...
Isomannide derivatives as inhibitors of soluble epoxide hydrolase
The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I...
Method for manufacturing 1,4:3,6-dianhydrohexitol di(alkyl carbonate)s
The present invention relates to a process for the manufacturing of pure and substantially oligomers-free 1,4:3,6-dianhydrohexitol di(alkyl carbonate)s which...
Novel compounds are disclosed having the structure of Formula I: ##STR00001## wherein, n is an integer from 1 to 5; X is --CN, --F, --Cl, --Br, --I,...
The present invention is directed to a compound of Formula (I): wherein: The present invention is directed to a compound of Formula (I): wherein: .cndot.n is an...
Substituted imidazo[1,2-d]pyrrolo[1,2-d]pyrazines for treating respiratory
syncytial virus infections
The present invention relates to compounds of formula (I) ##STR00001## its salts, isomers or prodrugs thereof useful in the treatment of viral infections, in...
Crystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of ...
Pyrrolopyrimidine compounds as kinase inhibitors
Disclosed herein are pyrrolo[2,3-d]pyrimidine compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors...
The invention relates to compounds of formula I ##STR00001## wherein A.sub.1, A.sub.2, A.sub.3, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in...
Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
Compounds of formula (I) and salts thereof: ##STR00001## wherein R.sub.1 is n-C.sub.4-6alkyl or C.sub.1-2alkoxyC.sub.1-2alkyl-; R.sub.2 is hydrogen or methyl;...
Crystalline forms of a Bruton's tyrosine kinase inhibitor
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
Anti-angiogenesis compound, intermediate and use thereof
Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect...
The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes,...
(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of
The invention relates to (1,2,4)triazolo[4,3-a]quinoxaline derivatives which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous...
Composition comprising purine derivatives or salt thereof for preventing
or treating atopic dermatitis
The present invention provides a pharmaceutical composition for preventing or treating atopic dermatitis comprising 2-amino-1,9-dimethylpurin-6-one or its...
2,6,7,8 substituted purines as HDM2 inhibitors
The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are...
Hexahydrodiazepinoquinolines carrying a substituted alkyl radical
The present invention relates to tricyclic hexahydrodiazepinoquinolines, such as compounds of formula (I), carrying a substituted alkyl radical, to a method for...
Kappa opioid receptor effectors and uses thereof
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder...
Nitrogen-containing heterocyclic compounds and organic electronic device
comprising the same
The present invention provides a nitrogen-containing heterocyclic compound and an organic electronic device including the same.
This invention relates to a compound of formula I ##STR00001## wherein A and Cy have one of the meanings as indicated in the specification and their use as...
Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to...
Substituted quinazolin-4(3H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones,
In one aspect, the invention relates to 3-benzylquinazolin-4(3H)-one analogs, derivatives thereof, and related compounds, which are useful as positive...