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Patent # Description
US-9,546,183 Forms of rifaximin and uses thereof
The present invention relates to Rifaximin polymorphic forms, to their use in medicinal preparations and to therapeutic methods using them.
US-9,546,182 Tricyclic PI3K inhibitor compounds and methods of use
Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically...
US-9,546,181 Compound having perfluoroalkyl terminal group and CF.sub.2O bonding group, liquid crystal composition and...
The subject is to provide a liquid crystal compound satisfying at least one of physical properties such as a high stability to heat or light, a high clearing...
US-9,546,180 Heterocyclic compounds and uses thereof
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods...
US-9,546,179 Heterocycle amido alkyloxy substituted quinazoline derivative and use thereof
Heterocycle amino alkyloxy substituted quinazoline derivatives as represented by the structural Formula (I) and pharmaceutically acceptable salts thereof,...
US-9,546,178 Benzoxazepin PI3K inhibitor compounds and methods of use
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof,...
US-9,546,177 Synthesis of noroxymorphone from morphine
The present invention is directed to an improved process to convert morphine into noroxymorphone having economic and ecological advantages.
US-9,546,176 Small molecule bicyclic and tricyclic CFTR correctors
Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a...
US-9,546,175 Organic compounds
The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), useful for the treatment of diseases or disorders characterized by disruption of or...
US-9,546,174 Inhibitor of apoptosis protein (IAP) antagonists
Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using...
US-9,546,173 Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitors
The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof; as further described herein. The present invention...
US-9,546,172 Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors
Disclosed herein are compounds such as those of Formula (I) that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible...
US-9,546,171 Preparation of ertapenem intermediates
The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the...
US-9,546,170 Hsp90 inhibitors
The disclosure relates to Compounds of Formula (1) : ##STR00001## and pharmaceutically acceptable salts thereof wherein Z.sub.1, Z.sub.2, Z.sub.3, Xa, Xb, Xc,...
US-9,546,169 Redox active triangular organic materials
A redox-active triangular prism is provided. The redox-active triangular prism includes a plurality of pure enantiomers selected from a group consisting of...
US-9,546,168 ERK inhibitors
Disclosed are the ERK inhibitors of formula (1.0) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the...
US-9,546,167 Radiosynthesis of tau radiopharmaceuticals
This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g.,...
US-9,546,166 Indolizine derivatives and their use in neurodegenerative diseases
The present invention relates to indolizine compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the...
US-9,546,165 Heterocyclic compounds useful as PDK1 inhibitors
The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating...
US-9,546,164 Substituted benzamides and methods of use thereof
The invention provides compounds having the general formula I: ##STR00001## and pharmaceutically acceptable salts thereof, wherein the variables R.sup.A,...
US-9,546,163 3,5-diaminopyrazole kinase inhibitors
Provided herein are 3,5-diaminopyrazoles, for example, compounds of Formula I, that are useful for modulating regulated-in-COPD kinase activity, and...
US-9,546,162 Compounds and methods for skin repair
The invention provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one EP4...
US-9,546,161 Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel...
US-9,546,160 Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
US-9,546,159 N-substituted 3,4-bis (catechol) pyrrole compounds, and the preparation and use thereof in the treatment of cancer
The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3,...
US-9,546,158 2,5-substituted pyrimidines
The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) ##STR00001## in which the chemical groupings, substituents...
US-9,546,157 Asymmetric piperidinyl-substituted ureas as medicines
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin...
US-9,546,156 N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
US-9,546,155 Aromatic heterocyclic compound
The compound represented by the general formula: wherein ring A is benzene which may be substituted and the like; ring B is benzene which may be substituted and...
US-9,546,154 Method for producing dabigatran etexilate methansulphonate
An improved method of preparing dabigatran etexilate mesylate (1-salt), ##STR00001## is described.
US-9,546,153 Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators
Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R.sup.2 is a bicyclic heterocycle, and...
US-9,546,152 2-pyridyloxy-3-substituted-4-nitrile orexin receptor antagonists
The present invention is directed to 2-pyridyloxy-3-substituted-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also...
US-9,546,151 VMAT inhibitory compounds
Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods...
US-9,546,150 Substituted quinazolin-4-ones for inhibiting ubiquitin specific protease 7
The present invention relates to quinazolin-4-one compounds of formula (I'), their process of preparation and uses thereof. These compounds are useful as...
US-9,546,149 IRE-1.alpha. inhibitors
Compounds which directly inhibit IRE-1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful...
US-9,546,148 Process for the production of trioxane from aqueous formaldehyde sources
The present invention relates to a process for producing cyclic acetal comprising i) preparing a liquid reaction mixture comprising a) a formaldehyde source, b)...
US-9,546,147 Method for producing cyclic carbonates
Linear or cyclic carbonates as potential monomers for isocyanate-free polyurethanes and polycarbonates were prepared from polyols and dialkyl carbonates or...
US-9,546,146 Migrastatins and uses thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
US-9,546,145 Combination therapy for the treatment of chronic renal failure with an angiotensin II receptor antagonist and...
An agent for enhancing therapeutic or prophylactic effect of a renin-angiotensin system inhibitor on renal diseases is disclosed, including a specific...
US-9,546,144 Bifunctional compounds
A compound having the formula: ##STR00001## wherein X is S, SO or SO.sub.2; one of R.sup.1, R.sup.2, and R.sup.3 is O and the others of R.sup.1, R.sup.2 and...
US-9,546,143 Method for preparing high-quality epoxidized fatty acid ester with micro-reaction device
A method for preparing a high-quality epoxidized fatty acid ester with a micro-reaction device, including: respectively pumping an aqueous hydrogen peroxide...
US-9,546,142 Process for preparing isoxaflutole
A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing ...
US-9,546,141 Salts
The present invention relates to new crystalline salt forms of flibanserine which have valuable pharmacological properties, to a process for their manufacture,...
US-9,546,140 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-N[4-(trifluorometho- xy)phenyl]-3-pyridinecarboxamide...
In the course of developing 2-[[[2-[(hydroxyacetyl) amino]-4-pyridinyl] methyl] thio]-N-[4-(trifluoromethoxy) phenyl]-3-pyridinecarboxamide (compound A), there...
US-9,546,139 Pyridine carboxylic acid based compound used as a P2X1 and P2X3 receptor antagonist, a production method for...
Provided are a novel pyridine carboxylic acid based compound used as a P2X.sub.1 and P2X.sub.3 receptor antagonist, a production method for the same and a...
US-9,546,138 Pyridone derivatives and uses thereof in the treatment of tuberculosis
A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of...
US-9,546,137 Methods of preparing Tecovirimat
Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly...
US-9,546,136 Method for preparation of imidodisulfuryl compounds
The invention relates to a method for the preparation of imidodisulfuryl compounds in a continuous reaction at elevated temperatures.
US-9,546,135 Solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopen- ...
A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopen- tyl)methyl)urea hydrochloride (also referred to "ATR-101")...
US-9,546,133 Method for producing copolymer for semiconductor lithography containing reduced amount of metal impurities, and...
A method for producing a copolymer for semiconductor lithography containing less metal impurities, and a method for purifying a polymerization initiator for...
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