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Patent # Description
US-9,550,815 ABC terpenoid transporters and methods of using the same
Provided are ATP-binding cassette transporters (ABC transporters). More specifically, the present disclosure relates to ABC terpenoid transporters, nucleic acid...
US-9,550,814 Multiple variants of meningococcal protein NMB1870
Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting ...
US-9,550,813 Disulfide stabilized foldon polypeptides
Intermolecular disulfide stabilized foldon polypeptides are provided.
US-9,550,812 Synthetic capsid proteins and uses thereof
The present invention relates to synthetic proteins and the uses thereof. More particularly, the invention relates to synthetic Circovirus type capsid proteins...
US-9,550,811 Peptide scaffold design
The present invention relates to novel peptides and methods for treatment, diagnosis and prognosis of virus infections including infections with HCV, HIV, CMV...
US-9,550,810 Biodegradable electroconducting nanowire, method of manufacture and uses thereof
The subject matter of the invention is an electroconducting nanowire, comprising an amyloid fiber which results from the self-assembling of peptides comprising...
US-9,550,809 High affinity metal-oxide binding peptides with reversible binding
A dodecamer peptide, and its modified variant, having a repeating glycine-lysine sequence was created and found to bind with high affinity to oxide surfaces and...
US-9,550,808 Peptide inhibitors of nicotinic acetylcholine receptor
The present invention refers to biochemistry, namely to new peptide compounds having the ability to selectively block the muscle-type nicotinic acetylcholine...
US-9,550,807 Inflammation inhibiting compounds
The present invention relates to the use of compounds selected from the group consisting of Lys-(D)Pro-Thr, N-acyl Lys-(D)Pro-Thr, C-amide Lys-(D)Pro-Thr, and...
US-9,550,806 Immunogenic compositions against human progastrin peptides
Immunogens against human extended-progastrin species comprise (A) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a N- and/or...
US-9,550,805 Precipitable peptides
The invention is directed to a Ca2+ precipitable polypeptide tags and cassettes useful for purification of molecules from heterogeneous samples. The invention...
US-9,550,804 Dosage form to increase prasterone bioavailability
A way to formulate prasterone to both increase its oral bioavailability, and decrease the variability of its oral bioavailability. ##STR00001## In contrast to...
US-9,550,803 Method to improve antiviral activity of nucleotide analogue drugs
An amino acid conjugate of a cyclic or acyclic nucleoside phosphonate is provided. In some cases, the amino acid conjugate is a tyrosine alkyl amide phosphonate...
US-9,550,802 Anti-inflammatory macrolides
The invention provides novel compounds and compositions and methods for making and using the compounds and compositions. In particular, the use of organic acid...
US-9,550,801 Synthesis of four coordinated platinum complexes and their applications in light emitting devices thereof
Platinum complexes that exhibit photoabsorption and photoemission, methods of making such complexes, and applications thereof are disclosed, including optical...
US-9,550,800 Transition metal carbene complex and method of producing the same
Provided are a transition metal carbene complex represented by the following general formula (1) and a method of producing the same. (In general formula (1), M...
US-9,550,799 Preparation of phosphorus-containing antiwear compounds for use in lubricant compositions
A process is provided for preparing a salt of a hydroxy-substituted ester of phosphoric acid, comprising: (a) reacting a phosphate diester with an alkylene...
US-9,550,798 Compounds that are S1P modulating agents and/or ATX modulating agents
Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX). ##STR00001##
US-9,550,797 Preparation of Grignard reagents using a fluidized bed
The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present...
US-9,550,796 Pyrrolopyrrolone derivatives and their use as BET inhibitors
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the...
US-9,550,795 Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, ##STR00001## as defined...
US-9,550,794 Macrocyclic pyridazinone derivatives
The present invention relates to compounds of formula (I) Wherein R1, R2, R3, R4, L and Z have the meaning given in claim 1, and their use in the prophylaxis...
US-9,550,793 Spirocyclic compounds, compositions and medicinal applications thereof
The present disclosure relates to a series of spirocyclic compounds of formula (I), their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts,...
US-9,550,792 Polycyclic substituted pyrazole kinase activity inhibitors and use thereof
The present invention relates to the field of medicinal chemistry, and in particular relates to 4-(five-membered heterocyclic pyrimidine/pyridine substituted)...
US-9,550,791 Functionnalized benzodithiophene polymers for electronic application
The present invention relates to polymers comprising a repeating unit of the formula (I), and their use as organic semiconductor in organic electronic devices,...
US-9,550,790 Thienopyranones as kinase inhibitors
The invention relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their...
US-9,550,789 Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
Provided herein are halogenated indole and benzofuran derivatives of isoquinuclidene and intermediates thereto, and processes, preferably enantioselective...
US-9,550,788 Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
The invention relates to substituted aminoindanes and analogs thereof of formula I ##STR00001## and the pharmaceutical use thereof. Medicaments which comprise...
US-9,550,787 Benzodiazepine derivatives
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and...
US-9,550,786 4-fluoropiperidine orexin receptor antagonists
The present invention is directed to 4-fluoropiperidine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention...
US-9,550,785 Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
The present invention relates to Compounds of formula (I) and salts thereof: ##STR00001## wherein R.sub.1 is n-C.sub.3-6alkyl; R.sub.2 is hydrogen or methyl;...
US-9,550,784 Inhibitors of phosphodiesterase 10 enzyme
The present invention relates to novel imidazo[1,2-b]pyridazine and imidazo[1,2-a]-pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme...
US-9,550,783 Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the...
US-9,550,782 Compounds and methods for treating diabetes
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic...
US-9,550,781 Kinase modulating compounds, compositions containing the same and use thereof
The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for...
US-9,550,780 Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2...
US-9,550,779 Derivatives and methods of treating hepatitis B infections
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
US-9,550,778 Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric...
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds;...
US-9,550,777 3-substituted pyrazoles and use as DLK inhibitors
The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various...
US-9,550,776 Pyridinylpyrazoloquinoline compounds
A compound represented by formula (I), or a pharmaceutically acceptable salt thereof: ##STR00001## wherein R.sup.1 represents a group represented by the...
US-9,550,775 Substituted triazolopyridines and methods of use thereof
The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables...
US-9,550,774 Dihydropyrido pyrimidine compounds as autotaxin inhibitors
The present invention provides compounds of the formula (I) or a pharmaceutically acceptable salt thereof. Compounds of the invention are autotaxin inhibitors...
US-9,550,773 Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines,...
US-9,550,772 Azaindole derivatives as multi kinase inhibitors
The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers,...
US-9,550,771 Keto-imidazopyridine derivatives as RORc modulators
Compounds of the formula I or II: ##STR00001## or pharmaceutically acceptable salts thereof, wherein R.sup.1 is a group of formula (a), (b), (c); (d) or (e): ...
US-9,550,770 Substituted quinazolines for inhibiting kinase activity
Chemical entities that are kinase inhibitors, pharmaceutical compositions containing the same, and methods of use thereof are described. Specifically...
US-9,550,769 Small molecules targeting repeat r(CGG) sequences
The invention provides a series of bioactive small molecules that target expanded r(CGG) repeats, termed r(CGG).sup.exp, that causes Fragile X-associated Tremor...
US-9,550,768 Kinase modulation and indications therefor
Compounds, compositions and methods useful for treatment of Flt3-mediated diseases or conditions are provided herewith. Also provided herewith are methods for...
US-9,550,767 Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of...
US-9,550,766 Isoindoline compounds and methods of their use
Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating,...
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