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Patent # Description
US-9,556,258 Purification of fusion proteins
The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention...
US-9,556,257 Antigen associated with rheumatoid arthritis
The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the detection and treatment of rheumatoid arthritis.
US-9,556,256 Inhibition of cancer metastasis
P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many...
US-9,556,255 Toxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding...
US-9,556,254 Cross-reactive antibodies against dengue virus and uses thereof
The invention relates to a human anti-dengue virus antibody (an anti-DENV antibody) that binds to a DENV envelope protein and is cross-reactive with DENV...
US-9,556,253 Process for increased yield of immunoglobulin from human plasma
The present invention discloses a preparation method for large scale production of human immunoglobulins (IgG) with high yields by an improved ...
US-9,556,252 Use of endostatin peptides for the treatment of fibrosis
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and...
US-9,556,251 Methods and compositions to regulate hepcidin expression
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and...
US-9,556,250 Double-acylated GLP-1 derivatives
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37)...
US-9,556,249 Neuregulin antagonists and use thereof in treating cancer
The invention provides neuregulin antagonists and methods of using the neuregulin antagonists in delaying the time to tumor recurrence or preventing resistance...
US-9,556,248 Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists
The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role...
US-9,556,247 Stabilized amyloid-beta oligomers and uses thereof
The present invention pertains to stabilized A.beta. oligomer compositions. Methods for generating stabilized A.beta. oligomer compounds are also provided...
US-9,556,246 SAP variants and their use
Polypeptides are susceptible to denaturation or enzymatic degradation in the blood, liver or kidney. Due to the low stability of some polypeptides, it has been...
US-9,556,245 CA125 gene and its use for diagnostic and therapeutic interventions
The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major...
US-9,556,244 Vaccination of animals to elicit a protective immune response against tick infestations and tick-borne pathogen...
Two antigenic and immunogenic proteins of the cattle tick, Rhipicephalus microplus, and the genes encoding these proteins, are effective for eliciting a...
US-9,556,243 Methods for making cytokine compositions from tissues using non-centrifugal methods
Apparatus and methods for generating a solution rich in interleukin-1 receptor antagonist from a tissue comprising cytokine-producing cells. The apparatus can...
US-9,556,242 Method for regulating circadian rhythms
The present invention relates to a composition for regulating circadian rhythms, a composition for diagnosing circadian rhythm disorders and a diagnostic kit,...
US-9,556,241 DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods
The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterized by...
US-9,556,240 Stable formulations of Neisseria meningitidis rLP2086 antigens
The present invention relates to stable formulations of Neisseria meningitis rLP2086 Subfamily B Antigens in immunogenic compositions. The present invention...
US-9,556,239 Polyvalent chimeric OSPC vaccinogen and diagnostic antigen
A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop...
US-9,556,238 Magnetosome gene expression in eukaryotic cells
The invention is the production of magnetosome-like structures in cells. The invention provides in vitro and in vivo diagnostic and therapeutic methods using...
US-9,556,237 Antiviral rift valley fever virus peptides and methods of use
The invention entails synthetic short peptides based on Rift Valley Fever Virus (RVFV) fusion protein. The peptides are broad-spectrum antivirals, and are...
US-9,556,236 Compositions and methods for treating respiratory syncytial virus infection
Briefly described, embodiments of the present disclosure relate to isolated polypeptides useful for treatment of respiratory syncytial virus, and to methods and...
US-9,556,235 F11 receptor (F11R) antagonists as therapeutic agents
The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic...
US-9,556,234 Template-fixed peptidomimetics
The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-.sup.DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-.sup.D- -Pro-Pro), disulfide bond between Cys4...
US-9,556,233 Cyclohexapeptide
The present invention relates to a novel cyclohexapeptide, to a method for the preparation of said cyclohexapeptide and to the use of said cyclohexapeptide.
US-9,556,232 Anti-angiogenic molecules, nanostructures and uses thereof
The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit...
US-9,556,231 Beta-hairpin peptidomimetics as CXC4 antagonists
.beta.-Hairpin peptidomimetics of the general formula cyclo(-Tyr.sup.1-His.sup.2-Xaa.sup.3-Cys.sup.4-Ser.sup.5-Ala.sup.6-Xaa.su- ...
US-9,556,230 TFPI inhibitors and methods of use
The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may...
US-9,556,229 Modification of peptides using a bis(thioether)arylbridge approach
This invention provides novel methods of stabilizing peptides and peptides so stabilized. In certain embodiments the methods involve providing a peptide...
US-9,556,228 Modified apidaecin derivatives as antibiotic peptides
This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to compositions and methods for...
US-9,556,227 Stitched polypeptides
The present invention provides inventive stitched polypeptides, pharmaceutical compositions thereof, and methods of making and using inventive stitched...
US-9,556,226 Peptides with antifungal activity and methods of using the peptides
Compositions with antifungal activity and methods of using such compositions are provided herein. In particular the compositions are peptides of SEQ ID NO: 1...
US-9,556,225 Peptide stimulator of cell survival and proliferation
The invention provides a novel peptide, and derivatives thereof, which is stable in aqueous solution and which stimulates proliferation and survival of...
US-9,556,224 Antimicrobial compositions and methods of use thereof
The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at...
US-9,556,223 Antimicrobial compounds
The present invention relates to a compound of formula (I) AA-AA-AA-R.sub.1--R.sub.2 (I) wherein, in any order, 2 of said AA (amino acid) moieties are cationic...
US-9,556,222 A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are...
US-9,556,221 N-acetyl amino acid ESTER derivatives of betulin and preparation method thereof
The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the...
US-9,556,220 Process for the preparation of drospirenone
A process is disclosed wherein, using either 17a-(3-hydroxypropyl)-6p,7p;15p,16p-dimethylene-5p-androstane-3p,5,17p-tr- iol (II) or ...
US-9,556,219 Procedure for the preparation of abiraterone acetate and intermediates thereof
Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a...
US-9,556,218 Process for the preparation of abiraterone and intermediates thereof
The present invention provides intermediates for preparing abiraterone, and processes for preparing abiraterone and intermediates thereof. The intermediates...
US-9,556,217 Amphiphilic compounds
Bringing membrane proteins into aqueous solution generally requires the use of detergents or other amphiphilic agents. The invention provides a new class of...
US-9,556,216 2'-Ethynyl nucleoside derivatives for treatment of viral infections
The present invention provides a compound of formula A: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein B, Q, R.sup.1, R.sup.5, R.sup.6,...
US-9,556,215 Synthetic pentasaccharides having short half-life and high activity
The invention concerns a pentasaccharide compound of formula (I) ##STR00001## and the salts thereof. The invention also concerns a pharmaceutical...
US-9,556,214 Compounds, compositions, and methods for the treatment of cancers
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
US-9,556,213 Phosphorescent meso-unsubstituted metallo-tetrabenzoporphyrin probe molecules for measuring oxygen and imaging...
Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as...
US-9,556,212 Chemical deposition raw material formed of ruthenium complex and method for producing the same, and chemical...
The present invention provides a raw material, formed of a ruthenium complex, for producing a ruthenium thin film or a ruthenium compound thin film by a...
US-9,556,211 Metal complex compound, hydrogen production catalyst and hydrogenation reaction catalyst each comprising the...
Provided is a catalyst for producing hydrogen, which catalyst has higher performance than conventional catalysts since, for example, it exhibits a certain high...
US-9,556,210 System for delivering therapeutic agents into living cells and cells nuclei
The present invention relates to a novel delivery system for delivering therapeutic agents into living cells, and more particularly, to novel chemical moieties...
US-9,556,209 Process for the ruthenium catalyzed trans-selective hydrostannation of alkynes
The present invention refers to a process for the ruthenium-catalyzed trans-selective hydrostannation of alkynes and the so-obtained products. The inventive...
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