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Patent # Description
US-9,556,208 Hydrosilylation synthesis of haloalkylorganosilanes using peroxide promoters
This invention is directed to a process for producing a haloorganoalkoxysilane product comprising reacting an olefinic halide, an alkoxysilane, a catalytically...
US-9,556,207 Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
US-9,556,206 Base-catalyzed silylation of terminal alkyne C--H bonds
The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising...
US-9,556,205 Fungicide N-[(trisubstitutedsilyl)methyl]-carboxamide derivatives
The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and...
US-9,556,204 Methods and intermediates for the preparation of ...
The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((- ...
US-9,556,203 Conformationally restricted P13K and mTOR inhibitors
The invention relates to novel phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor compounds of formula (I) and (II), which are...
US-9,556,202 Sulfonamide derivatives and methods of use thereof for improving the pharmacokinetics of a drug
The present invention relates to Sulfonamide Derivatives of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, wherein A, W, X, R.sup.1,...
US-9,556,201 Bicyclic pyridines and analogs as sirtuin modulators
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a...
US-9,556,200 Tricyclic compound
The present invention provides a compound having a superior serotonin 5-HT.sub.2C receptor activating action. The present invention relates to a compound...
US-9,556,199 Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
This invention relates to thieno[3,2-d]pyrimidines derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral...
US-9,556,198 Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity,...
US-9,556,197 Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the...
US-9,556,196 Anti-platelet compound addition salt
The present invention relates to a use of haloid acid salt and sulfonate of a compound of formula I and a salt of the compound of formula I in preparation of...
US-9,556,195 Compositions and methods for quadricyclane modification of biomolecules
The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves...
US-9,556,194 Furo[3,4-b]pyran compounds and pharmaceutical uses
Furo[3,4-b]pyran compounds similar in chemical structure to the natural product known as TAN-2483B and their use for treating cancer, osteoporosis, Type 2...
US-9,556,193 Benzimidazole hexahydrofuro[3,2-b]furan derivatives
The novel benzimidazole hexahydrofuro[3,2-B]furan derivatives of the present invention are activators of AMP-protein kinase and may be useful in the treatment,...
US-9,556,192 Functionalized 9-bromo-camptothecin derivatives
The present disclosure is directed to a compound of formula (I) ##STR00001## wherein L is null or a conditionally-cleavable moiety; W is null or a...
US-9,556,191 Aminoquinazoline derivatives and their salts and methods of use thereof
Provided herein are aminoquinazoline compounds, salts and uses thereof. The compounds have Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an...
US-9,556,190 Piperidinyloxy lactone orexin receptor antagonists
The present invention is directed to piperidinyloxy lactone compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
US-9,556,189 Polymorphic forms of naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and...
US-9,556,188 Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulators
The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed...
US-9,556,187 Substituted pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same
This disclosure relates to novel tricyclic pyrimidine compounds and tricyclic pyridine compounds having JAK inhibitory activities. A tricyclic heterocyclic...
US-9,556,186 Organic compounds
Provided are PDE1 inhibitors of Formula I, processes for their production, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
US-9,556,185 Organic compounds
The present invention relates to optionally substituted 4,5,7,8-tetrahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-(1H or ...
US-9,556,184 Phosphoinositide 3-kinase inhibitors
The present invention relates inter alia to a compound of formula (I) ##STR00001## and to compositions comprising the same and to the use of the compounds and...
US-9,556,183 Substituted pyrazolylpyrazole derivative and use of same as herbicide
Provided is a compound capable of effectively control worst weeds of higher leaf stages that present practical problems. A specific pyrazolylpyrazole derivative...
US-9,556,182 Inhibitors of Bruton's tyrosine kinase
Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible...
US-9,556,181 Substituted pyrazolopyrimidinylamino-indazoles
The present invention relates to substituted pyrazolopyrimidinylamino-indazole compounds of formula I, below, as described and defined herein, to methods of...
US-9,556,180 Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such...
US-9,556,179 Substituted imidazoles as casein kinase 1 D/E inhibitors
The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity...
US-9,556,178 Imidazotriazinecarbonitriles useful as kinase inhibitors
The invention provides compounds of Formula (I) ##STR00001## and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein...
US-9,556,177 Substituted 1,3-thiazoles as synthetic intermediates for preparation of Raf kinase inhibitors
The present disclosure provides compounds having Formula II-vi-a: ##STR00001## wherein Cy.sup.1, Cy.sup.2, and A.sup.- are defined as set forth in the...
US-9,556,176 Purine derivatives for the treatment of viral infections
The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating...
US-9,556,175 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and thier use as pharmaceutical compositions
The present invention relates to substituted xanthines of general formula ##STR00001## wherein R.sup.1 to R.sup.3 are as defined herein, the tautomers, the...
US-9,556,174 (2S, 5R)-sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester
A process for preparation of (2S, 5R)-Sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester is disclosed ...
US-9,556,173 Method for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(aS,7aS)-octahydro-6H-pyr- ...
This invention relates to methods for preparation of chemical compound 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-py- ...
US-9,556,172 Processes for the manufacture of propane-1-sulfonic acid ...
According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 ##STR00001## as well as intermediates...
US-9,556,171 Certain protein kinase inhibitors
Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.
US-9,556,170 Substituted-1H-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (LSD1) inhibitors
The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 ("LSD1"). The present invention also relates to...
US-9,556,169 Compounds and compositions for the treatment of parasitic diseases
The present invention provides compounds of formula I: ##STR00001## or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the...
US-9,556,168 N-alkylated indole and indazole compounds as RORgammaT inhibitors and uses thereof
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the...
US-9,556,167 TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or...
US-9,556,166 Proteostasis regulators
The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX),...
US-9,556,165 Amidine substituted .beta.-lactam compounds, their preparation and use as antibacterial agents
The present invention relates to novel .beta.-lactam compounds, their preparation and use. In particular, this invention relates to novel .beta.-lactam...
US-9,556,164 Salts of Dasatinib in crystalline form
The present invention primarily relates to molecular crystalline substances, preferably salts of Dasatinib in crystalline form, comprising a compound of formula...
US-9,556,163 Process for the preparation of a rivaroxaban and intermediates formed in said process
The invention relates to a process for the preparation of 5-chloro-N-({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-1,3-oxazoli- dine-5-yl}-methyl)...
US-9,556,162 Compound for the treatment of hepatitis C
The present invention provides (R)-5-(3-((2-(1,2,4-oxadiazol-3-yl)propan-2-yl)carbamoyl)phenyl)-6-(sec-b- ...
US-9,556,161 Inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y, Z and ##STR00002## have...
US-9,556,160 Guanidine compound
[Problem] The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical...
US-9,556,159 Renin inhibitor
The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. ##STR00001## ...
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