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Patent # Description
US-9,556,158 Fungicidal 3-[(pyridin-2-ylmethoxyimino)(phenyl)methyl]-2-substituted-1,2,- 4-oxadiazol-5(2H)-one derivatives
The present invention relates to 3-[(pyridin-2-ylmethoxyimino)(phenyl)methyl]-2-substituted-1,2,4-oxadiazo- l-5(2H)-one derivatives of formula (I), their process...
US-9,556,157 Enhancer of zeste homolog 2 inhibitors
This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions...
US-9,556,156 Compounds, their synthesis and their uses
The present invention discloses novel chemical compounds obtained by causing a covalent attachment of a modifying agent of the structure provided for formula 1,...
US-9,556,155 Methods of treating fatty liver disease
The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by...
US-9,556,154 Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising same and use thereof
The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use...
US-9,556,153 JAK1 inhibitors
The present invention relates to certain benzimidazole compounds, or pharmaceutically acceptable salts thereof, that inhibit Janus kinase 1 (JAK1),...
US-9,556,152 Heterocyclic amides as kinase inhibitors
Disclosed are compounds having the formula: ##STR00001## wherein X, Y, Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4, R.sup.5, R.sup.A, m, A, L, and B are as defined...
US-9,556,151 Maleate salts of a quinazoline derivative useful as an antiangiogenic agent
The present invention relates to AZD2171 maleate salt, to particular crystalline forms of AZD2171 maleate salt, to processes for their preparation, to...
US-9,556,150 Inhibitors of bruton's tyrosine kinase
This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit Btk. The compounds...
US-9,556,149 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor
The present invention relates to processes for preparing pyrazole derivatives of Formula (I) and salts and pharmaceutical compositions of the salts thereof,...
US-9,556,148 N-cyanomethylamides as inhibitors of janus kinase
The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in...
US-9,556,147 Inhibitors of bruton's tyrosine kinase
This application discloses compounds according to generic Formula I: (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds...
US-9,556,146 Lanthionine synthetase C-like 2-based therapeutics
Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including...
US-9,556,145 2-pyridyloxy-4-ester orexin receptor antagonists
The present invention is directed to 2-pyridyloxy-4-ester compounds which are antagonists of orexin receptors. The present invention is also directed to uses of...
US-9,556,144 Compound as WNT signaling inhibitor, composition, and use thereof
The present invention relates to a compound having the structure of Formula I as inhibitor of WNT signal transduction pathways, as well as a composition...
US-9,556,143 Metalloenzyme inhibitor compounds
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by...
US-9,556,142 Process for the preparation of (R,S)-nicotine
A method of preparing (R,S)-nicotine, comprising reacting a nicotinate ester with N-vinyl-2-pyrrolidinone in the presence of a base and a solvent to form a...
US-9,556,141 Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof
The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carboxylate compound of the formula (I-A) ##STR00001## comprising the...
US-9,556,140 Approach for synthesis of catechins
A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or -) epicatechin and its intermediates, comprising the...
US-9,556,139 6-substituted phenoxychroman carboxylic acid derivatives
Provided herein are compounds of Formula I: ##STR00001## in which A.sup.1, A.sup.2, W, L, G, R.sup.7a, R.sup.7b, R.sup.8, R.sup.9 and R.sup.10 have the...
US-9,556,138 Method of treatment for acne and an anti-acne formulation
The present disclosure relates to an anti-acne formulation comprising at least one active ingredient selected from the group consisting of coumarin based...
US-9,556,137 Methods for preparing alkylfurans
Provided herein are methods for preparing alkylfurans, such as 2,5-dialkylfurans and 2-alkylfurans. Furfural or 5-alkylfurfural can be reacted with aniline or...
US-9,556,136 Process for the distillation of a mixture comprising a cyclic N-vinylamide
A process for the distillation of a mixture which consists to at least 90% by weight of a cyclic N-vinylamide and which comprises a stabilizer, wherein a...
US-9,556,135 Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula...
US-9,556,134 Humic acid derivatives and methods of preparation and use
Disclosed are antioxidative natural compounds, their salts, chelates and cleavage derivatives that exhibit a superior combination of properties. The compounds...
US-9,556,133 Polycyclic LPA1 antagonist and uses thereof
Described herein is the LPA1 antagonist 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphe- nyl-4-yl}-cyclopropanecarboxylic acid...
US-9,556,132 Tetrazole derivatives and their use as potassium channel modulators
A tetrazole derivative of general formula (I), a pharmaceutical composition comprising said compound and its use for treating, alleviating or preventing...
US-9,556,131 Compositions, methods of use, and methods of treatment
Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor,...
US-9,556,130 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: ##STR00001## which...
US-9,556,129 Phosphatidylcholine transfer protein inhibitors
This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention...
US-9,556,128 Preparation method for acrylate compound
The present invention relates to a method for preparing an acrylate compound. The acrylate compound has a structure as shown in formula (I). The method...
US-9,556,127 Diaminopyrimidines as P2X.sub.3 and P2X.sub.2/3 antagonists
Compounds and methods for treating diseases mediated by a P2X.sub.3 and/or a P2X.sub.2/3 receptor antagonist, the methods comprising administering to a subject...
US-9,556,126 Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
Provided herein are diaminopyrimidyl Compounds having the following structures: ##STR00001## wherein X, L, R.sup.1, and R.sup.2 are as defined herein,...
US-9,556,125 Process for preparing a pyrimidine intermediate
The invention relates to a process for preparing a pyrimidine intermediate, namely the compound of formula I-2 ##STR00001## or a salt thereof, which involves...
US-9,556,124 Methods for removing triazine from N-methylimidazole for synthesis of oligonucleotide
Methods for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a N-methylimidazole and methods for making oligonucleotides using...
US-9,556,123 Synthesis of triethylenetetramines
Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and...
US-9,556,122 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of...
US-9,556,121 Pyridyloxyalkyl carboxamides and use thereof as endoparasiticides and nematicides
The present application relates to novel pyridyloxyalkylcarboxamides of the formula (I) ##STR00001## and to their use as endoparasiticides against...
US-9,556,120 Compositions for modulating a kinase cascade and methods of use thereof
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts....
US-9,556,119 Process for preparing desmosine, isodesmosine, and derivatives thereof
A process for preparing a compound represented by the following general formula (I) or a salt thereof, which comprises reacting lysine or a protective product...
US-9,556,118 Allosteric modulators of CB1 cannabinoid receptors
The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the...
US-9,556,117 Indole carboxamide derivatives as P2X.sub.7 receptor antagonists
The invention relates to indole carboxamide derivatives of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7,...
US-9,556,116 Krill oil refinery for purification of krill oil extract
Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide...
US-9,556,115 Sulfonamides for the prevention of diabetes
The use of sulfonamides of formula (I) ##STR00001## wherein R and R.sup.1 are as defined in the description, for the preparation of medicaments for the...
US-9,556,114 Fluorinated 2-amino-4-(benzylamino)phenylcarbamate derivatives
The invention relates to fluorinated compounds and their use as anti-epileptic, muscle-relaxing, fever-reducing and peripherally analgesically acting...
US-9,556,113 Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment
The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention...
US-9,556,112 Carboxylic acid ester prodrug inhibitors of MEK
The invention generally relates to compounds having structure I: ##STR00001## wherein x represents alkyl, aryl or het-aryl, each of y independently...
US-9,556,111 Tertiary amines for use in the treatment of cardiac disorders
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds...
US-9,556,110 Aminoalcohol lipidoids and uses thereof
Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from...
US-9,556,109 Triscationic amphiphile derivative compounds having a pendent alcohol group, compositions thereof, and methods...
The inventive subject matter relates to compounds of Formula I, compositions thereof, and processes for making such compounds as further described herein. The...
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