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Silk fibroin and polyethylene glycol-based biomaterials
This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active...
Preparations based on fibrinogen and sulfated polysaccharides
The present invention provides a preparation comprising fibrinogen and a sulfated polysaccharide as a one component composition or as a kit of parts comprising...
Microbicidal composite material
A composite material having inherent microbicidal activity is herewith described. The microbicidal composite material comprises of a first layer having a first...
Poured and/or compressed multiple wax object
The invention includes an improved multiple component wax object that may be advantageously cubic or in another shape such as similar to tree bark that may be...
Method for catalyzing a fenton reaction
A method for catalyzing a Fenton reaction, including adding hydrogen peroxide to a Fenton reaction catalyst, the Fenton reaction catalyst including a reaction...
Fenton reaction catalyst using coffee grounds or tea dregs as raw material
A Fenton reaction catalyst including a reaction product as an active component, in which the reaction product is obtained by using roasted and ground coffee...
Ex vivo antimicrobial devices and methods
A method and device for destroying and inhibiting exposure to microbes and infection includes a first element and a second element, and a power source. At least...
In an embodiment, a sterilization apparatus, adapted to sterilize a liquid to be sterilized, comprises a first sterilization light source, a first container and...
Ultraviolet light source and methods
A method for a smart-device comprising receiving a user selection of an icon on a display, initiating acquisition of a first image of a target surface using a...
Sterilizing device and sterilization method having energy recovery
The present invention relates to a sterilizing device (1), comprising at least one chamber (2) for sterilizing products (4), a primary fluid circuit (3)...
Bacteria-targeted magnetic resonance contrast agents
The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to...
Systems and methods of performing NMR spectroscopy and MRI
A method of performing Nuclear Magnetic Resonance (NMR) spectroscopy or Magnetic Resonance Imaging (MRI). The methods may include: a) generating a compound...
Fluorescent fusion polypeptides and methods of use
Embodiments of the present invention provide for the facile generation of a stable recombinant fusion polypeptides with intrinsic fluorescent properties. The...
Methods and compositions for inhibiting viral entry into cells
Disclosed herein are methods and compositions for inhibiting viral entry into cells.
Molecular containers and methods of making and using same
Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to...
Carrier-antibody compositions and methods of making and using the same
Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also...
Intestinal peptide targeting ligands
Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by...
Methods and compositions for the treatment of cancer and infectious
disease using alpha(2)...
The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for...
Peptides and methods using same
The present invention includes a method of modulating the phagocytic activity of at least one phagocyte in a subject. The present invention also includes a...
Positively charged polysaccharides for RNA transfection
A complex includes RNA and a positively charged modified polysaccharide selected from starch, amylose, amylopectin, galactan, chitosan, or dextrin. The complex...
Mono- and di-peg IL-10 production; and uses
Provided are methods of producing mono- and di-pegylated IL-10.
Dasatinib and nonlinear configuration polyethylene glycol conjugate
A dasatinib and nonlinear configuration polyethylene glycol conjugate represented by formula I, wherein core is the core structure of a nonlinear configuration...
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid
conjugates of hydromorphone, prodrugs,...
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone ...
Compounds for treatment of heart failure
A combination of: a first tetracycline (TC) component; and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO...
Compounds including Cox inhibitor moiety and enhanced delivery of active
drugs using same
The presently-disclosed subject matter includes compounds including a cyclooxygenase enzyme inhibitor moiety and a moiety derived from a drug of interest. In...
Monomers and oligonucleotides comprising cycloaddition adduct(s)
The invention features compounds of formula V or XII: ##STR00001## In one embodiment, the invention relates compounds and processes for conjugating ligand to...
Systems and methods of using chemically bound antibiotics activated by
Methods, devices and systems are disclosed for chemically bonding antibiotics to selected substrate materials which are not dissolved in normal physiological...
Vaccine delivery method
The present invention includes a composition including as one component a slurry matrix that is a liquid at room temperature and a gel at physiological pH,...
Powder mixtures for antibiotic dry syrup formulations
The present invention provides a pharmaceutical formulation prepared as dry syrups representing mere powder mixtures of beta-lactam antibiotics as active...
In situ gelling drug delivery system
The invention provides liquid controlled-release drug delivery compositions which gel upon injection into the body to form, in situ, controlled-release drug...
Protein sequencing method and reagents
The invention describes methods and reagents useful for sequencing polypeptide molecules. The method comprises affixing a polypeptide to a substrate and...
Combinations of a PI3K/AKT inhibitor compound with an HER3/EGFR inhibitor
compound and use thereof in the...
The invention provides combinations comprising GDC-0068 or GDC-0941, or a pharmaceutically acceptable salt thereof and ME-HD7945A. The combinations are...
Compositions and methods for diagnosing and treating hyperthyroidism in
An isolated DNA molecule comprising a fragment of the gene encoding the feline NIS is disclosed as well as methods of use thereof. Also provided are methods for...
Methods of treating multiple sclerosis
The preset invention relates to combination pharmaceutical composition comprising an activated-potentiated from of an antibody to gamma interferon, and an...
A composition for treating cancer, including synergistic amounts of a primary cell-derived biologic having the cytokines IL-1, IL-2, IL-6, IL-8, TNF-.alpha.,...
Immunogenic composition for immune system modulation and use thereof,
method for treating and preventing...
The present invention relates to immunogenic compositions for modulating the immune system, comprising a therapeutically effective quantity of two or more...
Live, attenuated rubella vector to express vaccine antigens
Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) without an in-frame...
Computationally optimized broadly reactive antigens for H1N1 influenza
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus...
Computationally optimized broadly reactive antigens for human and avian
Described herein is the generation of optimized H5N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus...
Adjuvanted influenza vaccines for pediatric use
An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared...
Therapeutic vaccines for treating herpes simplex virus type-2 infections
The invention provides methods and kits for inducing a therapeutic immunity in animals (e.g. mammals) against viral antigens, including herpes-simplex virus...
North American porcine reproductive and respiratory syndrome (PRRS) virus
and uses thereof
The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North...
Vaccine for cervical cancer
The present invention relates to a pharmaceutical vaccine composition for a human cervical cancer, comprising: (a) (i) a L1 virus-like particle (VLP) of human...
Bacterial vaccine components and uses thereof
Agents, compositions, methods and kits useful for the treatment and diagnosis of Staphylococcal intramammary infection are disclosed. The agents, compositions,...
Immunomodulatory minicells and methods of use
The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
Mucin-associated surface protein as vaccine against Chagas disease
Use of synthetic peptides derived from Trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and Chagas disease. T. cruzi...
p16.sup.INK4a derived peptides for prophylaxis and therapy of
HPV-associated tumors and other p16.sup.INK4a...
Described are particular fragments of the cyclin-dependent kinase inhibitor p16 capable of increasing IFN-.gamma. secretion of T cells or inducing proliferation...
The invention relates to producing humoral response to P2X7 receptors in individuals having cancer, and to minimizing the progression of cancer in said...
Treatment of ophthalmic conditions
Ophthalmic conditions such as presbyopia, myopia, and astigmatism can be corrected by the use of a molding contact lens in combination with a pharmaceutical...
Variant, recombinant beta-glucocerebrosidase proteins with increased
stability and increased retained catalytic...
Described herein are variant, recombinant .beta.-glucocerebrosidase proteins characterized as having increased stability relative to recombinant wild-type...