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Method for producing polyethylene
The present invention relates to a method for consecutively producing at least two different polyethylene resins in one slurry loop reactor, comprising...
Peptides having binding affinity to an antibody which recognizes an
epitope on an .alpha.1 loop 2 or .beta.2...
A peptide having an ED.sub.50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular .alpha.1 loop 2 or .beta.2...
Complex of bi-specific antibody and digoxigenin conjugated to a
therapeutic or diagnostic agent
The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a...
Methods for treating muscle specific receptor kinase (MuSK) myasthenia
gravis with the Ig1 domain of MuSK
Agents, compositions, and medicaments that reduce interactions between muscle specific kinase receptor (MuSK) and pathogenic immunoglobulin G4 (IgG4) antibodies...
Chimeric antigen receptor compositions
Provided herein are compositions which exhibit novel diagnostic capabilities and allow to rapidly add functionality to adoptive immunotherapy. The compositions...
Antibodies against factor XII and uses thereof
Provided are antibodies that selectively bind to and inhibit activation of coagulation factor XII. Methods of treatment employing these antibodies are described...
AGR2 blocking antibody and use thereof
Disclosed is an AGR2 blocking monoclonal antibody, and in particular, a humanized monoclonal antibody for blocking AGR2. Also disclosed is a pharmaceutical...
Antibodies against tissue factor pathway inhibitor
The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies...
Stable heterodimeric antibody design with mutations in the Fc domain
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc...
Polynucleotides encoding VEGF/DLL4 binding agents
The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating...
CD27L antigen binding proteins
The present invention relates to CD27L antigen binding proteins, such an antibodies, polynucleotides encoding said CD27l antigen binding proteins, antibody drug...
B7-H3L cell surface antigen and antibodies that bind thereto
The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of...
Optimized anti-CD30 antibodies
An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered...
Stable Protein-containing preparation containing argininamide or analogous
Addition of argininamide or valinamide to a highly concentrated antibody solution was found to lead to remarkable stabilization, in particular, stabilization...
Methods for treating or preventing asthma by administering an IL-4R
The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise...
Low fucose cell lines and uses thereof
A method of selecting cells having zero fucose level useful as host cells for expressing recombinant proteins is disclosed. The method comprises: (d)...
Human antigen binding proteins that bind to a complex comprising
.beta.-Klotho and an FGF receptor
The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like...
Humanized single-chain antibody against beta 3 integrin for the treatment
and prevention of metastasis
The present invention relates to methods inhibiting tumor metastasis and treating cancer in a subject that involve administering to the subject an antibody...
Anti-human B7-H4 antibodies and their uses
Anti-human B7-H4 antibody "6H3", antigen-binding fragments, derivatives, and humanized variants thereof that are capable of immunospecifically binding to B7-H4,...
CTLA-4 antibody dosage escalation regimens
A disease or condition, such as cancer or an infectious disease, can be treated in a patient by administering a CTLA-4 antibody in an escalating dosage regimen...
Antibodies against human FZD5 and FZD8
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human...
Method for use in the treatment of aneurysm
The present invention relates to a compound which is an antagonist of IL-1 beta or an inhibitor of IL-1 beta expression for use in the treatment or the...
Monoclonal antibodies to human proinflammatory cytokines and methods for
treating inflammatory diseases
A monoclonal secretory IgA antibody, which binds to and neutralizes a human proinflammatory cytokine or which binds to and blocks a human proinflammatory...
Compositions and methods for growth factor modulation
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth...
A.beta. protofibril binding antibodies
The present invention relates to the amyloid beta peptide (A.beta.) and more specifically to antibodies binding to A.beta. protofibrils and their use in therapy...
Pharmaceutical composition for treatment of cancer comprising an
anti-CAPRIN-1 peptide antibody
The invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic...
Serum albumin binding proteins
The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially...
Human monoclonal antibodies derived from human B cells and having
neutralizing activity against influenza A viruses
The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with...
Method of producing a plurality of isolated antibodies to a plurality of
The present invention relates to a method for producing high affinity antibodies that are antigen-specific. The method involves binding a plurality of...
Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein...
Effective targeting of primary human leukemia using anti-CD123 chimeric
antigen receptor engineered T cells
The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The...
CTP-based insulin analogs for treatment of diabetes
Insulin analogs comprising a non-native glycosylation site sequence are provided having high potency and specificity for the insulin receptor. In one embodiment...
Modified ghrelin peptides
The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular...
p16 protein variant and use thereof for preventing or treating cancer
A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition...
Chimeric inhibitor molecules of complement activation
The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of...
Compositions including I-domain antigen conjugate compounds and methods
for treatment of autoimmune disorders
The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC...
The present invention provides modified tamabidin 2, which is a modified biotin-binding protein comprising an amino acid sequence represented by SEQ ID NO: 2,...
Epsilon toxin epitopes from Clostridium perfringens with reduced toxicity
There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a...
Fusion proteins and methods for stimulating plant growth, protecting
plants from pathogens, and immobilizing...
The present invention is generally directed to fusion proteins containing a targeting sequence that targets the fusion protein to the exosporium of a Bacillus...
Modified VP1-capsid protein of parvovirus B19
The invention relates to a modified VP1-capsid protein of parvovirus B19 having a reduced phospholipase A2-like enzyme activity as compared to the wild type...
Cyclosporin derivatives for the treatment and prevention of a viral
The present invention relates to a compound of the formula (I), (II), (III), (IV), (V), or (VI) or pharmaceutically acceptable salt thereof, wherein the symbols...
Method for preventing neoplastic transformation by inhibition of
retinoblastoma protein inactivation
A method for preventing neoplastic transformation by inhibition of cell cycle progression into S phase by preventing the inactivation of Retinoblastoma protein...
Antagonist for (pro)renin receptor for the treatment of hypertension and
Methods and compositions for increasing a plant's resistance to an insect pest such as the corn rootworm are provided. Methods are provided for overexpression...
Melanoma antigen peptide and uses thereof
The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 1, SEQ ID NO:2,...
Multi-leu peptides and analogues thereof as selective PACE4 inhibitors and
effective antiproliferative agents
Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation,...
Separation method and separation matrix
The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a...
Nurotoxic sterol glycosides
The invention relates to compositions for use in animal models of neurodegenerative disease and methods therefor. More particularly, the invention relates to...
Method of preparation of antiviral compounds and useful intermediates
The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The...
The present invention provides a compound of Formula I or hydrate thereof, useful for the treatment of diabetes. ##STR00001##
Compounds and compositions as kinase inhibitors
The present invention provides a compound of Formula I: ##STR00001## wherein X, Y, Z, R.sub.1 and R.sub.2 are as described herein, and salts thereof and...