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Patent # Description
US-9,574,018 Method for producing polyethylene
The present invention relates to a method for consecutively producing at least two different polyethylene resins in one slurry loop reactor, comprising...
US-9,574,017 Peptides having binding affinity to an antibody which recognizes an epitope on an .alpha.1 loop 2 or .beta.2...
A peptide having an ED.sub.50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular .alpha.1 loop 2 or .beta.2...
US-9,574,016 Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a...
US-9,574,015 Methods for treating muscle specific receptor kinase (MuSK) myasthenia gravis with the Ig1 domain of MuSK
Agents, compositions, and medicaments that reduce interactions between muscle specific kinase receptor (MuSK) and pathogenic immunoglobulin G4 (IgG4) antibodies...
US-9,574,014 Chimeric antigen receptor compositions
Provided herein are compositions which exhibit novel diagnostic capabilities and allow to rapidly add functionality to adoptive immunotherapy. The compositions...
US-9,574,013 Antibodies against factor XII and uses thereof
Provided are antibodies that selectively bind to and inhibit activation of coagulation factor XII. Methods of treatment employing these antibodies are described...
US-9,574,012 AGR2 blocking antibody and use thereof
Disclosed is an AGR2 blocking monoclonal antibody, and in particular, a humanized monoclonal antibody for blocking AGR2. Also disclosed is a pharmaceutical...
US-9,574,011 Antibodies against tissue factor pathway inhibitor
The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies...
US-9,574,010 Stable heterodimeric antibody design with mutations in the Fc domain
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc...
US-9,574,009 Polynucleotides encoding VEGF/DLL4 binding agents
The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating...
US-9,574,008 CD27L antigen binding proteins
The present invention relates to CD27L antigen binding proteins, such an antibodies, polynucleotides encoding said CD27l antigen binding proteins, antibody drug...
US-9,574,007 B7-H3L cell surface antigen and antibodies that bind thereto
The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of...
US-9,574,006 Optimized anti-CD30 antibodies
An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered...
US-9,574,005 Stable Protein-containing preparation containing argininamide or analogous compound thereof
Addition of argininamide or valinamide to a highly concentrated antibody solution was found to lead to remarkable stabilization, in particular, stabilization...
US-9,574,004 Methods for treating or preventing asthma by administering an IL-4R antagonist
The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise...
US-9,574,003 Low fucose cell lines and uses thereof
A method of selecting cells having zero fucose level useful as host cells for expressing recombinant proteins is disclosed. The method comprises: (d)...
US-9,574,002 Human antigen binding proteins that bind to a complex comprising .beta.-Klotho and an FGF receptor
The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like...
US-9,574,001 Humanized single-chain antibody against beta 3 integrin for the treatment and prevention of metastasis
The present invention relates to methods inhibiting tumor metastasis and treating cancer in a subject that involve administering to the subject an antibody...
US-9,574,000 Anti-human B7-H4 antibodies and their uses
Anti-human B7-H4 antibody "6H3", antigen-binding fragments, derivatives, and humanized variants thereof that are capable of immunospecifically binding to B7-H4,...
US-9,573,999 CTLA-4 antibody dosage escalation regimens
A disease or condition, such as cancer or an infectious disease, can be treated in a patient by administering a CTLA-4 antibody in an escalating dosage regimen...
US-9,573,998 Antibodies against human FZD5 and FZD8
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human...
US-9,573,997 Method for use in the treatment of aneurysm
The present invention relates to a compound which is an antagonist of IL-1 beta or an inhibitor of IL-1 beta expression for use in the treatment or the...
US-9,573,996 Monoclonal antibodies to human proinflammatory cytokines and methods for treating inflammatory diseases
A monoclonal secretory IgA antibody, which binds to and neutralizes a human proinflammatory cytokine or which binds to and blocks a human proinflammatory...
US-9,573,995 Compositions and methods for growth factor modulation
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth...
US-9,573,994 A.beta. protofibril binding antibodies
The present invention relates to the amyloid beta peptide (A.beta.) and more specifically to antibodies binding to A.beta. protofibrils and their use in therapy...
US-9,573,993 Pharmaceutical composition for treatment of cancer comprising an anti-CAPRIN-1 peptide antibody
The invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic...
US-9,573,992 Serum albumin binding proteins
The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially...
US-9,573,991 Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses
The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with...
US-9,573,990 Method of producing a plurality of isolated antibodies to a plurality of cognate antigens
The present invention relates to a method for producing high affinity antibodies that are antigen-specific. The method involves binding a plurality of...
US-9,573,989 Sgp130/Fc dimers
Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein...
US-9,573,988 Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The...
US-9,573,987 CTP-based insulin analogs for treatment of diabetes
Insulin analogs comprising a non-native glycosylation site sequence are provided having high potency and specificity for the insulin receptor. In one embodiment...
US-9,573,986 Modified ghrelin peptides
The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular...
US-9,573,985 p16 protein variant and use thereof for preventing or treating cancer
A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition...
US-9,573,984 Chimeric inhibitor molecules of complement activation
The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of...
US-9,573,983 Compositions including I-domain antigen conjugate compounds and methods for treatment of autoimmune disorders
The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC...
US-9,573,982 Modified tamavidin
The present invention provides modified tamabidin 2, which is a modified biotin-binding protein comprising an amino acid sequence represented by SEQ ID NO: 2,...
US-9,573,981 Epsilon toxin epitopes from Clostridium perfringens with reduced toxicity
There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a...
US-9,573,980 Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing...
The present invention is generally directed to fusion proteins containing a targeting sequence that targets the fusion protein to the exosporium of a Bacillus...
US-9,573,979 Modified VP1-capsid protein of parvovirus B19
The invention relates to a modified VP1-capsid protein of parvovirus B19 having a reduced phospholipase A2-like enzyme activity as compared to the wild type...
US-9,573,978 Cyclosporin derivatives for the treatment and prevention of a viral infection
The present invention relates to a compound of the formula (I), (II), (III), (IV), (V), or (VI) or pharmaceutically acceptable salt thereof, wherein the symbols...
US-9,573,977 Method for preventing neoplastic transformation by inhibition of retinoblastoma protein inactivation
A method for preventing neoplastic transformation by inhibition of cell cycle progression into S phase by preventing the inactivation of Retinoblastoma protein...
US-9,573,976 Antagonist for (pro)renin receptor for the treatment of hypertension and diabetes
Methods and compositions for increasing a plant's resistance to an insect pest such as the corn rootworm are provided. Methods are provided for overexpression...
US-9,573,975 Melanoma antigen peptide and uses thereof
The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 1, SEQ ID NO:2,...
US-9,573,974 Multi-leu peptides and analogues thereof as selective PACE4 inhibitors and effective antiproliferative agents
Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation,...
US-9,573,973 Separation method and separation matrix
The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a...
US-9,573,972 Nurotoxic sterol glycosides
The invention relates to compositions for use in animal models of neurodegenerative disease and methods therefor. More particularly, the invention relates to...
US-9,573,971 Method of preparation of antiviral compounds and useful intermediates thereof
The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The...
US-9,573,970 4-{4-[(1E)-4-(2,9-diazaspiro[5.5]undec-2-yl)but-1-en-1-yl]-2-methylbenzyl}- -5-(propan-2-yl)-1H-pyrazol-3-yl...
The present invention provides a compound of Formula I or hydrate thereof, useful for the treatment of diabetes. ##STR00001##
US-9,573,969 Compounds and compositions as kinase inhibitors
The present invention provides a compound of Formula I: ##STR00001## wherein X, Y, Z, R.sub.1 and R.sub.2 are as described herein, and salts thereof and...
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