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Patent # Description
US-9,573,967 N-heterocyclic carbene gold complexes with anticancer properties and methods of use thereof
Monomeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one N-heterocyclic carbene ligand and one monodentate...
US-9,573,966 Anti-cancer activity of novel bicyclic heterocycles
The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof...
US-9,573,965 Process for the preparation of Dolutegravir
The present invention provides (R)-3-Amino-1-butanol (D)-tartarate (IIb); process for its preparation and its conversion to Dolutegravir. The present invention...
US-9,573,964 Oxygen linked pyrimidine derivatives
The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen...
US-9,573,963 Fused heterocyclic compound and pest control applications thereof
A fused heterocyclic compound represented by formula (1) or an N-oxide thereof has an excellent control effect on pests: ##STR00001## wherein A.sup.1...
US-9,573,962 Antimicrobial compounds and methods of making and using the same
The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for...
US-9,573,961 Inhibitors of the renal outer medullary potassium channel
The present invention provides compounds of Formula I ##STR00001## and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK...
US-9,573,960 Glioblastoma inhibiting compounds and their use
The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma....
US-9,573,959 Methods for preparing SGLT2 inhibitors
This invention relates to methods for preparing a sodium-glucose transporter 2 (SGLT2) inhibitor, a cocrytalline SGLT2 and (S)-5-oxopyrrolidine-2-carboxylic...
US-9,573,958 Benzimidazole derivatives as ITK inhibitors
The present disclosure is directed to certain inhibitors of kinases such as ITK, BLK, BMX, BTK, JAK3, TEC, TXK, HER2 (ERBB2), or HER4 (ERBB4), in particular...
US-9,573,957 Inhibitors of leukotriene production
The present invention relates to aryl pyrazoles, and pharmaceutically acceptable salts thereof. The aryl pyrazoles of the present invention are useful as...
US-9,573,956 Compounds as dual inhibitors of phosphodiesterases and histone deacetylases
It relates to certain compounds having a polycyclic structure and a hydroxamic acid moiety, wherein the polycyclic structure comprises at least three ring...
US-9,573,955 Compounds
Heterocyclic compounds and salts according to formula (I), which are pyrimidinone derivatives, described herein exhibit human neutrophil elastase inhibitory...
US-9,573,954 Pyrazolopyrimidine compounds
The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are...
US-9,573,953 Heteroaromatic compounds as PI3 kinase modulators and methods of use
The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase...
US-9,573,952 Methods of preparing toll-like receptor modulators
The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-- 6(5H)-one and related compounds.
US-9,573,951 Crystalline forms of a purine derivative
The present invention relates to new crystalline forms of a purine derivative which exhibits excellent anti-tumor activity. The invention also relates to a...
US-9,573,950 Substituted [1,4]diazepino[6,7,1-ij]quinolines as serotonin 5-HT2C receptor modulators
The present invention relates to compound of formula (I) as tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, useful for modulating the...
US-9,573,949 Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38--MAP kinase inhibitors
Mitogen activated protein kinase (MAPK) inhibitors disclosed herein are useful for the treatment of diseases of the respiratory tract, such as chronic...
US-9,573,948 Triazolopyridine compounds and methods for the treatment of cystic fibrosis
The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective...
US-9,573,947 Salt of pyrazoloquinoline derivative, and crystal thereof
The present invention provides a salt of (S)-7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-py- razolo[4,3-c]quinolin-4(5H)-one and an acid...
US-9,573,946 Compounds and methods for inhibiting fascin
Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in...
US-9,573,945 Anxiolytic compounds
The present invention relates to chemical compounds of general formula (I) ##STR00001## which may possess useful therapeutic activity in a range of central...
US-9,573,944 Heterocyclyl compounds
The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and...
US-9,573,943 Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts...
US-9,573,942 HIV inhibiting 5-amido substituted pyrimidines
This invention concerns pyrimidine derivatives of formula ##STR00001## having HIV (Human Immunodeficiency Virus) replication inhibiting properties, the...
US-9,573,941 Processes for preparing dihydropyrimidine derivatives and intermediates thereof
The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as...
US-9,573,940 4-aminoquinazolinyl-2-yl-1-pyrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors
Aminoquinazolinyl compounds of formula (I) are described, ##STR00001## which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in...
US-9,573,939 Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such...
US-9,573,938 Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as...
US-9,573,937 Substituted pyridine and pyrazine compounds as PDE4 inhibitors
The invention provides a chemical entity of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z have any of the values described...
US-9,573,936 Triazole agonists of the APJ receptor
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the...
US-9,573,935 Quinoline derivative
A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon...
US-9,573,934 Methods and compositions for the synthesis of multimerizing agents
The invention features methods and compositions for the synthesis of multimerizing agents.
US-9,573,933 Inhibitors of the interaction between MDM2 and P53
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising...
US-9,573,932 Synthesis of intermediates in the preparation of ALK inhibitor
The present disclosure provides a method for preparing a compound of formula XVII, comprising: (1) contacting a compound of formula XIV with a compound of...
US-9,573,931 Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by coupling 3-bromopyridine with commercially available 3-aminopyrazole, purifying the...
US-9,573,930 Inhibitors of lysine specific demethylase-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
US-9,573,929 Muscarinic M1 receptor agonists
This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated...
US-9,573,928 N-phenyl-2-pyrimidine-amine derivatives
The present invention relates to novel amides and a process for preparing these amides.
US-9,573,927 Compositions and methods for the treatment of severe pain
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
US-9,573,926 Amidoalkylenyl and amidoaryl esters, compositions thereof, and methods for their use
The invention provides ester compounds for treating ophthalmic diseases. The esters of the invention are particularly advantageous due to their stability in...
US-9,573,925 Process for recovering and improving production of meso-lactide from a crude lactide containing stream
A process for the recovery and production of meso-lactide from a crude lactide containing stream may include subjecting a starting crude lactide stream to a...
US-9,573,924 Process for preparing cyclic esters and cyclic amides
A process for preparing a cyclic ester or a cyclic amide includes contacting hydroxycarboxylic acid and/or amino-carboxylic acid, an ester thereof, or a salt...
US-9,573,923 Liquid crystal compound having 2, 6-difluorophenylether structure, and liquid crystal composition containing...
The present invention relates to a compound having a 2,6-difluorophenylether structure useful as organic electronic materials, pharmaceuticals and...
US-9,573,922 Process-scale synthesis of urolithins
Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially...
US-9,573,921 Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as H.sub.1-receptor antagonists
The present invention relates to compounds of formula (I), and salts thereof and the pharmaceutical composition containing them in treatment of various...
US-9,573,920 Compound, medicine, anti-inflammatory, cosmetic, food and drink, and method for producing compound
A compound is represented by Formula (I) or (II) described below. ##STR00001## A medicine includes, as an active ingredient, a compound represented by Formula...
US-9,573,919 Peroxisome proliferator-activated receptor (PPAR) activator, and drugs, supplements, functional foods and food...
The present invention provides a peroxisome proliferator-activated receptor (PPAR) activator, which is free from the problem of side effects, can be taken over...
US-9,573,918 Fumigillol compounds and methods of making and using same
The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of...
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