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N-heterocyclic carbene gold complexes with anticancer properties and
methods of use thereof
Monomeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one N-heterocyclic carbene ligand and one monodentate...
Anti-cancer activity of novel bicyclic heterocycles
The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof...
Process for the preparation of Dolutegravir
The present invention provides (R)-3-Amino-1-butanol (D)-tartarate (IIb); process for its preparation and its conversion to Dolutegravir. The present invention...
Oxygen linked pyrimidine derivatives
The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen...
Fused heterocyclic compound and pest control applications thereof
A fused heterocyclic compound represented by formula (1) or an N-oxide thereof has an excellent control effect on pests: ##STR00001## wherein A.sup.1...
Antimicrobial compounds and methods of making and using the same
The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for...
Inhibitors of the renal outer medullary potassium channel
The present invention provides compounds of Formula I ##STR00001## and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK...
Glioblastoma inhibiting compounds and their use
The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma....
Methods for preparing SGLT2 inhibitors
This invention relates to methods for preparing a sodium-glucose transporter 2 (SGLT2) inhibitor, a cocrytalline SGLT2 and (S)-5-oxopyrrolidine-2-carboxylic...
Benzimidazole derivatives as ITK inhibitors
The present disclosure is directed to certain inhibitors of kinases such as ITK, BLK, BMX, BTK, JAK3, TEC, TXK, HER2 (ERBB2), or HER4 (ERBB4), in particular...
Inhibitors of leukotriene production
The present invention relates to aryl pyrazoles, and pharmaceutically acceptable salts thereof. The aryl pyrazoles of the present invention are useful as...
Compounds as dual inhibitors of phosphodiesterases and histone
It relates to certain compounds having a polycyclic structure and a hydroxamic acid moiety, wherein the polycyclic structure comprises at least three ring...
Heterocyclic compounds and salts according to formula (I), which are pyrimidinone derivatives, described herein exhibit human neutrophil elastase inhibitory...
The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are...
Heteroaromatic compounds as PI3 kinase modulators and methods of use
The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase...
Methods of preparing toll-like receptor modulators
The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-- 6(5H)-one and related compounds.
Crystalline forms of a purine derivative
The present invention relates to new crystalline forms of a purine derivative which exhibits excellent anti-tumor activity. The invention also relates to a...
Substituted [1,4]diazepino[6,7,1-ij]quinolines as serotonin 5-HT2C
The present invention relates to compound of formula (I) as tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, useful for modulating the...
Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38--MAP kinase
Mitogen activated protein kinase (MAPK) inhibitors disclosed herein are useful for the treatment of diseases of the respiratory tract, such as chronic...
Triazolopyridine compounds and methods for the treatment of cystic
The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective...
Salt of pyrazoloquinoline derivative, and crystal thereof
The present invention provides a salt of (S)-7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-py- razolo[4,3-c]quinolin-4(5H)-one and an acid...
Compounds and methods for inhibiting fascin
Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in...
The present invention relates to chemical compounds of general formula (I) ##STR00001## which may possess useful therapeutic activity in a range of central...
The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and...
Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts...
HIV inhibiting 5-amido substituted pyrimidines
This invention concerns pyrimidine derivatives of formula ##STR00001## having HIV (Human Immunodeficiency Virus) replication inhibiting properties, the...
Processes for preparing dihydropyrimidine derivatives and intermediates
The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as...
4-aminoquinazolinyl-2-yl-1-pyrazole-4-carboxylic acid compounds as prolyl
Aminoquinazolinyl compounds of formula (I) are described, ##STR00001## which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in...
Substituted benzofuran compounds and methods of use thereof for the
treatment of viral diseases
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such...
Therapeutic hydroxypyridinones, hydroxypyrimidinones and
The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as...
Substituted pyridine and pyrazine compounds as PDE4 inhibitors
The invention provides a chemical entity of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z have any of the values described...
Triazole agonists of the APJ receptor
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the...
A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon...
Methods and compositions for the synthesis of multimerizing agents
The invention features methods and compositions for the synthesis of multimerizing agents.
Inhibitors of the interaction between MDM2 and P53
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising...
Synthesis of intermediates in the preparation of ALK inhibitor
The present disclosure provides a method for preparing a compound of formula XVII, comprising: (1) contacting a compound of formula XIV with a compound of...
Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by coupling 3-bromopyridine with commercially available 3-aminopyrazole, purifying the...
Inhibitors of lysine specific demethylase-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
Muscarinic M1 receptor agonists
This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated...
The present invention relates to novel amides and a process for preparing these amides.
Compositions and methods for the treatment of severe pain
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
Amidoalkylenyl and amidoaryl esters, compositions thereof, and methods for
The invention provides ester compounds for treating ophthalmic diseases. The esters of the invention are particularly advantageous due to their stability in...
Process for recovering and improving production of meso-lactide from a
crude lactide containing stream
A process for the recovery and production of meso-lactide from a crude lactide containing stream may include subjecting a starting crude lactide stream to a...
Process for preparing cyclic esters and cyclic amides
A process for preparing a cyclic ester or a cyclic amide includes contacting hydroxycarboxylic acid and/or amino-carboxylic acid, an ester thereof, or a salt...
Liquid crystal compound having 2, 6-difluorophenylether structure, and
liquid crystal composition containing...
The present invention relates to a compound having a 2,6-difluorophenylether structure useful as organic electronic materials, pharmaceuticals and...
Process-scale synthesis of urolithins
Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially...
Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as
The present invention relates to compounds of formula (I), and salts thereof and the pharmaceutical composition containing them in treatment of various...
Compound, medicine, anti-inflammatory, cosmetic, food and drink, and
method for producing compound
A compound is represented by Formula (I) or (II) described below. ##STR00001## A medicine includes, as an active ingredient, a compound represented by Formula...
Peroxisome proliferator-activated receptor (PPAR) activator, and drugs,
supplements, functional foods and food...
The present invention provides a peroxisome proliferator-activated receptor (PPAR) activator, which is free from the problem of side effects, can be taken over...
Fumigillol compounds and methods of making and using same
The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of...