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Process for the manufacture of epoxy-monomers and epoxides
A process for manufacturing epoxy monomers and/or epoxides in high yields and useful quality and chemical stability by dehydrochlorination of the corresponding...
Method for the production of ethylene oxide
A method for the production of ethylene oxide wherein the partial pressure of water vapor at the inlet of the reactor is at least about 8 kPa using a high...
Ionic liquids, the method for preparing the same and method for removing
acetylenes from olefin mixtures using...
There are provided an ionic liquid having ether group(s) in which a copper(I) compound is included, a method for preparing the same, and a method for removing...
Process for preparing benzothiazepines from gamma-aminoalkylbenzenes
The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: ##STR00001## by reacting a [2-(acylaminoethyl)thio]arene...
Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and...
Tetracycline derivatives with reduced antibiotic activity and
The present disclosure is directed to compositions and methods which utilize the tetracycline scaffold, preferably the scaffold of tetracycline or minocycline,...
Diphosphate mimetics and uses thereof
The present invention provides compounds of Formulae (I)-(V), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. In one aspect,...
Oxazolidinone antibacterial compound
The invention relates to novel oxazolidinone compound. More particularly, the invention relates to novel [(S)--N-[[3-[4-fluoro-3-morpholino ...
6-acyl-1,2,4-triazine-3,5-dione derivative and herbicides
Disclosed are triazine derivative compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and...
Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in
Using a whole-cell high-throughput screen, eleven molecules were identified that activate V. cholerae quorum sensing (QS). Eight molecules are receptor agonists...
2, 4-pyrimidine derivatives and use thereof
The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for...
The invention provides compounds of formulae (I), (II), (III), and (IV): and salts thereof, as well as pharmaceutical compositions comprising such compounds....
Process to obtain mixtures of imidazolines and corrosion inhibitors from
The biphasic extraction from coffee waste without a prior drying process, to obtain coffee oil, which is transesterified with KOH catalyzed methanol to produce...
Aromatic compound and use thereof
An aromatic compound represented by formula (1): ##STR00001## wherein R.sup.1 and R.sup.2 each independently represents a halogen atom, a C1-C4 alkyl group,...
The present invention provides a heterocyclic compound having a ROR.gamma.t inhibitory action. The present invention relates to a compound represented by the...
Process for the preparation of Ivacaftor and its intermediates
The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation...
Crystal form of chidamide, preparation method and use thereof
The present invention belongs to the field of pharmaceutical chemistry, and disclosed are two crystal forms of Childamide, that is, Chidamide crystal form A and...
Polymorphs of deuterated omega-diphenylurea or salts thereof
The invention relates to polymorphs of deuterated omega-diphenylurea or salts thereof. In particular, the invention provides polymorphs of ...
USP7 inhibitor compounds and methods of use
2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof,...
Pyridine derivates and their use as Umami tastants
Compounds of the formula (1) and their use as umami tastants: ##STR00001## wherein R.sub.1 is chosen from Me, Et, Pr, or iPr, R.sub.2 is chosen from H or Me,...
Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods...
Methods for preparing d-threo-methylphenidate using diazomethane, and
Novel methods and systems for producing a substantially pure d-threo stereoisomer of methylphenidate or a salt thereof are provided. In particular, methods and...
The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for...
Processes for the preparation of prostaglandin amides
The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, ##STR00001## where in the formula, the...
Complexes of agomelatine and sulphonic acids, a process for their
preparation and pharmaceutical compositions...
Complexes of agomelatine and sulphonic acids of formula (I): ##STR00001## Medicinal products containing the same which are useful in treating disorders of the...
Process for producing taurine
There is disclosed a process for producing taurine by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or...
Methods and compositions for making an amino acid triisocyanate
A method of making an amino acid triisocyanate is provided, the method comprising reacting an amino acid trihydrochloride with phosgene to form the amino acid...
The invention provides compounds of formula I: ##STR00001## or a salt thereof as described herein. The invention also provides pharmaceutical compositions...
The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) ##STR00001## (R is as...
Hydroxy-substituted amino and ammonium derivatives and their medical use
The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use,...
Methods of treating cerebral edema
The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for...
Imidazoline amides and derivitives from natural oil metathesis
Fatty amide compositions and their derivatives are disclosed. The fatty amides comprise a reaction product of a metathesis-derived C.sub.10-C.sub.17...
Salts of carnitine derivatives and methods of production
Disclosed are salts, such as nitrates, of acetyl-L-carnitine and propionyl-L-carnitine and methods of making the compounds.
Use of 4-[ethyl(dimethyl)ammonio]butanoate in the treatment of
New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
Halogenated aniline and method for producing same
The present invention provides a halogenated aniline represented by formula (I) (wherein each of X.sup.1 and X.sup.2 independently represents a chlorine atom, a...
Benzo lipoxin analogues
Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are...
Monoesters, inner complex salts or monoester salts of hexahydro-beta-acid
and application thereof as animal...
Disclosed are monoesters, inner complex salts or monoester salts of hexahydro-.beta.-acid, and application thereof as animal feed additives. The compounds as...
Process for the preparation of the monomer pentabromobenzyl acrylate and
A process for preparing pentabromobenzyl acrylate through the reaction of pentahalobenzyl halide with a salt of acrylic acid in a water-immiscible solvent,...
Process for producing vinyl acetate
The present invention relates to a process for forming vinyl acetate. The process comprises the step of providing a reaction mixture having an initial heat...
Retro-aldol reaction products and methods of making and using same
The presently disclosed and/or claimed inventive concept(s) relates generally to retro-aldol reaction products and methods of making and using same. More...
Procedure for the obtainment of fatty acids of pharmacological and
This invention refers to a procedure for obtaining fatty acids of pharmacological and nutritional interest that comprises the steps of feeding a gas comprising...
Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid
In a non-limiting embodiment, there is provided a compound of formula (I), which may permit for a method or use in treating or preventing a cancer, such as...
Using mixtures of E/Z isomers to obtain quantitatively specific products
by combining asymmetric hydrogenation...
The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having...
Stereo controlled synthesis of (E,Z)-dienals via tandem Rh(I) catalyzed
propargyl claisen rearrangement
A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective...
Hetereocyclic agent as catalytic stabilizing agent in a hydroformylation
A heterocyclic nitrogen stabilizing agent is employed to reduce the rate of catalyst deactivation in a hydroformylation process.
Bisphenol A preparation apparatus and preparation method
Provided are an apparatus and a method for preparing bisphenol A. In the present invention, all or some of a mother liquid stream is circulated to a flash...
Method for purifying chlorinated hydrocarbon
The present invention provides a method for purifying chlorinated hydrocarbon(s), comprising cooling a mixture containing hydrogen fluoride and at least one...
Method for producing 2-chloro-3,3,3,-trifluoropropene (HCFC-1233xf)
The present invention relates to an improved method for manufacturing 2-chloro-3,3,3-trifluoropropene, (HCFC-1233xf) by reacting 1,1,2,3-tetrachloropropene,...
Aromatic hydrocarbon production apparatus
An apparatus includes a first distillation apparatus for obtaining a fraction enriched in C8+ aromatics; a second distillation apparatus for obtaining a...
Process for production of C3 olefin in a fluid catalytic cracking unit
A process for increasing the yield of C.sub.3 olefin in fluidized bed catalytic cracking of hydrocarbon feedstocks is disclosed. C.sub.4 fraction produced from...