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Radiolabeled compounds and their use as radiotracers for quantitative
imaging of phosphodiesterase (PDE10A) in...
The present invention provides radiolabeled compounds useful as radiotracers for quantitative imaging of PDE10A in mammals. The compound of the present...
Phospholipid ether analogs as agents for detecting and locating cancer,
and methods thereof
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer...
Method, compounds and preparations for the identification of sentinel
The present invention relates to methods for the identification of a sentinel lymph node and to compounds and preparations used in said methods.
Lanthanoid complex capsule and particle contrast agents, methods of making
and using thereof
The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid...
Nanostructure, applied device and preparation method thereof
A nanostructure is described. The nanostructure includes a nanoparticle, a shell encompassing the nanoparticle, and a gap having a width ranging from 1.0 nm to...
Heterocycle-substituted xanthene dyes
The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same,...
The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention...
Nanocarriers for drug delivery
The present invention provides a nanocarrier having an interior and an exterior, the nanocarrier comprising at least one conjugate, wherein each conjugate...
Retinal OFF circuit-specific promoter
The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid...
Pharmaceutical use of FAM19A5 involved in regulating gliogenesis
The present invention relates to the pharmaceutical use of FAM19A5 involved in regulating gliogenesis, and more specifically, to the use of FAM19A5 in the...
Computer-implemented systems and methods for analyzing court activity
A method of analysis and presentation of court document information includes: at least one of one or more servers providing, to a user, a user interface, the...
Finite fully addressable nucleic acid nanostructures as nanocarriers for
delivery of pharmaceuticals
The present invention provides nanostructures that are particularly well suited for delivery of bioactive agents to organs, tissues, and cells of interest in...
Cell penetrating peptides for intracellular delivery of molecules
A cell-penetrating peptide characterized in that it comprises an amino acid sequence X.sub.3X.sub.4X.sub.1X.sub.2X.sub.5X.sub.4X.sub.1X.sub.2X.sub.6X.sub.7X.s- ...
Polyanion nanocomplexes for therapeutic applications
The subject-matter of the present invention are nanocomplexes of polyanions and cationic peptides which are, e.g., suitable for the transport of drugs into...
Derivatisation of erythropoietin (EPO)
The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and...
Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation
Provided herein are polymeric .alpha.-hydroxy aldehyde or .alpha.-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable...
Conjugate based systems for controlled drug delivery
Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is...
Compounds and methods for producing a conjugate
The present disclosure provides conjugate structures and compound structures used to produce these conjugates. The disclosure also encompasses methods of...
Methods of preparing tamper resistant pharmaceutical formulations
Disclosed in certain embodiments is a solid oral dosage form comprising a heat-labile gelling agent; a thermal stabilizer; and a drug susceptible to abuse.
System and method for alleviating the appearance of scars and/or scar
A system for alleviating the appearance of scar tissue, said system comprising a combination of two compounds; a first compound having properties that perform...
Drug delivery system to increase bioavailability
A drug delivery system is presented to increase the bioavailability of biopharmaceutic class II, III, or IV active agents.
Drug loaded polymeric nanoparticles and methods of making and using same
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight...
Ophthalmic compositions comprising polyvinyl caprolactam-polyvinyl
acetate-polyethylene glycol graft copolymers
Compositions and methods related to ophthalmic use of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers and therapeutic uses are...
Method of treating bendamustine-responsive conditions in patients
requiring reduced volumes for administration
Methods of treating bendamustine responsive conditions in patients having fluid and/or sodium intake restrictions are disclosed. The methods include identifying...
Formulations for enhanced bioavailability of orally administered polar
A composition is described having improved oral permeability of polar agents such as neuraminidase inhibitors. The composition includes one or more polar agents...
Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte
The present disclosure relates to the use of a recombinant LAG-3 or derivatives thereof in order to boost a monocyte-mediated immune response, in particular to...
Magnetodynamic activation of .sup.13 C-acyl isoniazid and isoniazid and
The invention provides method of treating a subject suffering from, or at risk of developing, a Mycobacterium infection by administering to the subject a...
Microporation of tissue for delivery of bioactive agents
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is...
Saponin adjuvant compositions and methods relating thereto
An adjuvant composition which comprises an anionic macromolecule component particularly an ionic polysaccharide such as DEAE-dextran, and a saponin component,...
Combinations and uses thereof
The present disclosure describes a pharmaceutical combination of an anti-CD38 antibody and melphalan.
Yeast-based compositions and methods for the treatment or prevention of
hepatitis delta virus infection
Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV...
Antigenic peptide of HSV-2 and methods for using same
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells...
Chimeric poly peptides and the therapeutic use thereof against a
The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide...
Method for rapidly designing pharmaceutical preparations for preventing
Certain embodiments of the present invention include a method for rapidly designing pharmaceutical preparations for preventing viral infection that have adapted...
Porcine reproductive and respiratory syndrome virus, compositions, vaccine
and methods of use
The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing...
Meningococcal fHBP polypeptides
fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are...
Inactivated mycobacteria for oral use in the prevention of tuberculosis
An inactivated mycobacteria for oral use in the prevention of tuberculosis, which are administered using a multi-dose regimen and with a reduced time interval...
Compositions and methods for enterohemorrhagic Escherichia coli
Certain embodiments are directed to compositions comprising EHEC-specific antigens. In certain aspects EHEC O157:H7-specific antigen(s) are used as components...
Vaccine against Rhipicephalus ticks
The present invention generally relates to the fields of parasitology and immunology, and especially to a vaccine against Rhipicephalus ticks. In particular the...
Treatment of headache by injection of neuroinhibitory substance to
sphenopalatine ganglion or otic ganglion
A neuroinhibitory substance for use in a method for treating or preventing headache comprising injecting a neuroinhibitory substance such as botulinium toxin in...
C-terminally tethered amino acids and their fibrinolytic therapeutic uses
The present disclosure provides a C-terminal tethered amino acid for modulating the thrombolytic, fibrinolytic and/or anticoagulant properties of a coagulation...
Recombinant human NaGlu protein and uses thereof
The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu...
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
Methods for treating benign prostatic hypertrophy (BPH)
Therapeutic methods for treating a subject with benign prostatic hypertrophy by inhibition of the activity of insulin-like growth factor-I (IGF-I) to reduce the...
Method of lowering mortality
The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure....
Splice variants of GDNF and uses thereof
The present invention relates to Glial Cell Line-Derived Neurotrophic Factor (GDNF) protein and gene and is, in particular, directed to a novel splice variant...
Wnt antagonist and methods of treatment and screening
The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing...
Methods of treating or preventing periodontitis and diseases associated
The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also...
Method of treating prostate cancer with GnRH antagonist
The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone...
Compositions for binding to amyloid proteins
Compositions useful for the prevention and/or treatment of Alzheimer's disease are disclosed. The composition comprises carrier particles each linked to a...