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Fluoride-responsive riboswitches, fluoride transporters, and methods of
Disclosed are compounds, compositions, and methods relating to fluoride aptamers, fluoride-responsive riboswitches, fluoride-regulated expression constructs,...
Compositions and methods for treatment of prostate and other cancers
Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from...
Lipid particles with asymmetric cationic lipids for RNA delivery
What is described is a lipid particle comprising the compound of formula I ##STR00001## wherein R.sub.1 consists of alkyl, alkenyl, alkynyl, or cholesteryl;...
Methods and compositions for treating malignant tumors associated with
This invention provides methods and compositions for preventing, treating or ameliorating one or more symptoms of a malignant tumor associated with KRAS...
Double stranded RNA constructs for aphid control
Disclosed are specific aphid dsRNA constructs that target either Chloride Intracellular Channel (CLIC) gene expression or Sucrase gene expression. Also...
Multimeric oligonucleotides compounds
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)),...
Provided are methods and compositions for in vivo display and screening of peptides for antimicrobial activity. The methods can include expressing a random...
Innovative discovery of therapeutic, diagnostic, and antibody compositions
related to protein fragments of...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof,...
DHAD variants and methods of screening
Methods of screening for dihydroxy-acid dehydratase (DHAD) variants that display increased DHAD activity are disclosed, along with DHAD variants identified by...
Kexin-derived vaccines to prevent or treat fungal infections
A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine...
Polypeptides having protease activity
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also...
Thermostable cellobiohydrolase and amino acid substituted variant thereof
A thermostable cellobiohydrolase including a cellobiohydrolase catalytic domain, the cellobiohydrolase catalytic domain including: (A) a polypeptide including...
CRISPR hybrid DNA/RNA polynucleotides and methods of use
The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of...
Methods of improving the introduction of DNA into bacterial cells
The present invention relates to methods of improving the introduction of DNA into bacterial host cells.
TRPV1 modulatory gene product that affects TRPV1-specific pain behavioral
responses identified in a functional...
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by...
Mutant reverse transcriptase
A mutant MMLV reverse transcriptase that may have an improvement in one or more properties is provided. For example, the present reverse transcriptase is...
Enhanced nucleic acid constructs for eukaryotic gene expression
The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further...
Method for producing .gamma.-glutamylvalylglycine or a salt thereof
A method for producing .gamma.-Glu-Val-Gly comprising the step of reacting Val-Gly with a .gamma.-glutamyl group donor in the presence of a ...
Reduction of tobacco-specific nitrosamines using genetic modification to
elevate production of native...
Cured tobacco having a lower concentration of tobacco specific nitrosamines, can be produced from a transgenic tobacco plant having a heterologous nucleotide...
Ketoreductase polypeptides for the production of azetidinone
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme....
Recombinant influenza viruses for vaccines and gene therapy
The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses,...
Method for endotoxin removal
The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target...
Baculoviral vectors comprising repeated coding sequences with differential
The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the...
Attenuated recombinant alphaviruses incapable of replicating in mosquitoes
and uses thereof
The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors....
Induced pluripotent stem cells
Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription...
Kidney structures and methods of forming the same
Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro, and...
Method for culturing mesenchymal stem cells
Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of...
MSC surface marker
The present invention relates to the use of at least one antibody which binds to the SUSD2 antigen, or to functional fragments of the antibody, in combination...
Truncated epiderimal growth factor receptor (EGFRt) for transduced T cell
A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human...
Methods and compositions for the generation and maintenance of regulatory
Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune...
ES cell cytoplasm or ooplasm transfer to rejuventate recipient cells
Methods for de-differentiating or altering the life-span of desired "recipient" cells, e.g., human somatic cells, by the introduction of cytoplasm from a more...
Method for inducing endodermal and mesodermal differentiation from human
pluripotent stem cells by CXCR2...
The present invention relates to a method of inducing the differentiation of human pluripotent stem cells into endoderm and mesoderm by CXCR2 inhibition, and...
Method of manufacturing patterned substrate for culturing cells, patterned
substrate, and patterned cell chip
A method of manufacturing a patterned substrate for culturing cells. The method includes the steps of: (1) preparing a substrate, (2) forming a first plasma...
Canine probiotic bifidobacterium pseudolongum
According to the invention there is provided a strain of lactic acid bacteria of the species Bifidobacterium pseudolongum obtainable by isolation from resected...
Methods and devices for sample lysis
Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g.,...
Microfluidic tumor tissue dissociation device
A tissue dissociation device includes an inlet coupled to a first stage having a single channel having an upstream end and a downstream end; a plurality of...
Apparatus for filtering fluid and methods of isolating particle using the
Provided are an apparatus for filtering a fluid, the apparatus including a first flow channel and a second flow channel which are connected to each other in a...
Oenological product comprising compressed pieces of oak wood and a method
for preparing such a product
The present invention relates to an oenological product intended to be used in making wine or spirits. This product includes a piece of wood made of compressed...
Production of low-alcohol or alcohol-free beer with Pichia kluyveri yeast
It has unexpectedly been found that a low alcohol or alcohol-free beverage, with a flavor profile very close to a beer of at least 4% (vol/vol) alcohol, can be...
Method for adding hops in beer manufacture
The invention relates to a method for adding hops in beer manufacture, having the following process steps; a) separation of a sub-quantity (07a) of water and/or...
Composition comprising microcapsules
A liquid composition having a microcapsule, the microcapsule having an aldehyde-containing resin, and one or more formaldehyde scavenger which reacts with...
Cleaning composition and method for semiconductor device fabrication
Provided is a cleaning composition and its applications. The cleaning composition comprises a mixture of a halogen-containing compound and an organic solvent....
Intercalated bleach compositions, related methods of manufacture and use
The invention relates to compositions, methods of use, and methods of manufacture for an intercalated bleach compound and compositions thereof. The intercalated...
Consumer product compositions comprising organopolysiloxane conditioning
Consumer product compositions comprising organopolysiloxane conditioning polymers. Also disclosed are processes for making such compositions and to methods of...
Candle wax comprising a polymer and method for making candle wax
This invention pertains to candle wax and a method for making candle wax. The candle wax comprises a candle wax base mixture and a polymer wherein the polymer...
Process for producing purified essential oil
It is provided a process for producing a purified essential oil excellent in safety and quality with high productivity from an essential oil comprising a...
Articles having low coefficients of friction, methods of making the same,
and methods of use
Briefly described, embodiments of this disclosure include articles and methods of making articles.
Lubricating oil composition
A lubricating oil composition comprising (A) a lubricating oil base oil the kinematic viscosity of which at 100.degree. C. is in the range of from 1.4 to 6...
Countercurrent oxygen enhanced torrefaction
The invention relates to a method of torrefaction of an optionally predried biomass in a torrefaction reactor such that torrefied biomass and torrefaction gases...
Catalytic conversion method for improving product distribution
The present invention relates to a catalytic conversion process for improving the product distribution, characterized in that a feedstock oil of good quality is...