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Patent # Description
US-9,580,461 Method for purifying active polypeptides or immunoconjugates
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active...
US-9,580,460 Discordant helix stabilization for prevention of amyloid formation
The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to...
US-9,580,459 Water-soluble ursodeoxycholic acid prodrugs
Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use...
US-9,580,458 Polymorphic form of sodium hyodeoxycholate (NaHDC) and its preparation process
The object of the present invention is a new anhydrous polymorphic crystalline form of sodium hyodeoxycholate (NaHDC) named as form II (FII) and the process for...
US-9,580,457 Process for the preparation of (1-{9-[(4S, 2R, 3R, 5R)-3, ...
The present invention relates to a novel process for the preparation of (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminop- ...
US-9,580,456 Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis
The present invention relates to a compound of the general formula (I) for pulmonary administration. The compound of formula (I) is suitable for treating...
US-9,580,455 Process for the recovery of beta acetylfuranoside
There is provided an improved method for the recovery of residual, unseparated .beta.-acetylfuranoside from reaction mixtures remaining from an initial...
US-9,580,454 Biomass fractionation process for bioproducts
A fractionation process for producing value-added products from a lignocellulosic biomass, comprises: a) mechanically refining the lignocellulosic biomass under...
US-9,580,453 Preparation of transition metal carboxylates
This disclosure provides a process for making transition metal carboxylate compositions by combining in an polar aprotic first solvent a transition metal...
US-9,580,452 Antioxidant compound having anti atherosclerotic effect and preparation thereof
The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly...
US-9,580,451 Sulfonic esters of metal oxides and methods of their use
The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II: ##STR00001##
US-9,580,450 Colored charged silsesquioxanes
The present invention provides salts of a cation and an anion, wherein the cation comprises (i) a silsesquioxane moiety of formula ##STR00001## (ii) a...
US-9,580,449 Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their...
US-9,580,448 Boron ester fused thiophene monomers
A compound of formula (I), formula (II), or a combination thereof, and salts thereof is described. ##STR00001## Each A may be independently an optionally...
US-9,580,447 Highly heat-resistant phthalocyanine
The problem addressed by the present invention is to provide a high heat-resistant phthalocyanine. The phthalocyanine is separated by mixing a phthalocyanine...
US-9,580,446 Gas separation material using metal complex and gas separation method
A separation material and method for separating and recovering a target gas from a mixed gas including the target gas and a hydrocarbon gas that has the same...
US-9,580,444 Polycyclic pyrazolinone derivative and herbicide comprising same as effective component thereof
Provided are a polycyclic pyrazolinone derivative indicated by general formula (1) (in the formula, R.sup.1, X.sup.1, X.sup.2, X.sup.3, and Y indicate the...
US-9,580,443 Heterocyclic derivatives as modulators of kinase activity
The invention provides novel imidazol-piperidinyl derivatives of the formula (I) ##STR00001## in which R.sup.1, R.sup.2, W, X.sup.1, X.sup.2, X.sup.3, X.sup.4...
US-9,580,442 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N--H, N--(C.sub.1-C.sub.10 alkyl) or S; each X is independently CH or...
US-9,580,441 Dental compositions based on polymerizable resins containing isosorbide
Disclosed herein are polymerizable dental materials and dental products based upon such materials. More particularly, disclosed are materials and products based...
US-9,580,440 Polymorphs of darunavir
The present invention provides novel solvated forms of darunavir and processes for their preparation. The present invention also provides novel processes for...
US-9,580,439 Inhibitors of focal adhesion kinase
The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which...
US-9,580,438 Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and...
The invention relates to a compound of the general formula (I) or a physiologically functional derivative, solvate or salt thereof, ##STR00001## wherein A, X,...
US-9,580,437 Triazolopyrimidine compounds and uses thereof
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or...
US-9,580,436 Process of preparing alcaftadine
The present invention relates to an improved process of preparing substantially pure alcaftadine comprising reacting substantially pure compound of structural...
US-9,580,435 Pyrrolo[2,3-D]pyrimidine derivatives as CB2 receptor agonists
The invention relates to a compound of formula (I) ##STR00001## wherein A and R.sup.1 to R.sup.3 are defined as in the description and in the claims. The...
US-9,580,434 Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are amide compounds...
US-9,580,433 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-A]pyrazine derivatives as inhibitors of beta-secretase (BACE)
The present invention relates to novel 5,6-dihydroimidazo[1,5-a]pyrazinyl derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving...
US-9,580,432 Fused pyrimidine compound or salt thereof
Provided is a novel compound having BTK inhibitory action and a cell proliferation suppressing effect. Also provided is a medicine useful for the prevention...
US-9,580,431 Inhibitors of human immunodeficiency virus replication
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
US-9,580,430 9H-pyrimido[4,5-B]indoles and related analogs as BET bromodomain inhibitors
The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: ##STR00001## ...
US-9,580,429 Pyrrolo[3,2-D]pyrimidin-4-one derivatives and their use in therapy
There are disclosed novel compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.12, L, X and Y are as defined in the specification, and ...
US-9,580,428 Compositions and methods for inhibiting viral polymerase
Provided are compounds of Formula I: ##STR00001## as described herein. Compounds of Formula I are useful in methods of inhibiting viral RNA polymerase...
US-9,580,427 Kinase inhibitors
Provided herein are compounds such as the compounds having the structure of Formula (XI) ##STR00001## and methods of using the same, such as methods of...
US-9,580,426 Compounds that expand hematopoietic stem cells
The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell...
US-9,580,425 Pyrido[3,4-b] indoles and methods of use
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[4,3-b]indoles are described, as...
US-9,580,424 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt
The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104)...
US-9,580,423 Bicyclic heterocycles as FGFR4 inhibitors
The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in...
US-9,580,422 Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful...
US-9,580,421 Urea derivatives and uses thereof
The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
US-9,580,420 Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]h- ...
A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]h- eptan-1-ol and novel intermediates used in the...
US-9,580,419 Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as Janus kinase inhibitors
The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful...
US-9,580,418 Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity...
US-9,580,417 Prodrugs of heteraromatic compounds
The present invention relates to prodrugs of parent drug compounds containing heteroaromatic NH groups.
US-9,580,416 Inhibitors of Bruton's tyrosine kinase
Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk) having the structure of Formula (B): ##STR00001## Also disclosed are pharmaceutical...
US-9,580,415 Compounds
The compound of formula (I) are inhibitors of SSAO activity (Formula (I)) wherein the terms Y, Z, W, R.sup.1 and R.sup.2 are defined in the claims. ##STR00001##
US-9,580,414 Salts and hydrates of antipsychotics
The present invention relates to a novel salt of (3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(1,2-benzisothiazol-3-yl)-piperazin-1-y- ...
US-9,580,413 Substituted pyrrolidines as ROS tyrosine kinase inhibitors
The main purpose of the invention is to provide a novel aromatic heterocyclic derivative or a pharmaceutically acceptable salt thereof. Examples of the...
US-9,580,412 Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases
Methods for preparing disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds that correspond to general formula (I) are described. Also described are...
US-9,580,411 Substituted sulfonamide compounds
The invention is concerned with the compounds of formula (I): ##STR00001## and salts thereof, wherein X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.3', R.sup.4,...
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