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2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 1, ways to make it, compositions comprising it and made using it, and methods of...
Modulators of opioid receptors and methods of use thereof
Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of...
Polymorphic forms of nilotinib hydrochloride
Crystalline Forms R5, R5a, R5b and R6 of nilotinib hydrochloride and processes for their preparation.
Regioselective N-2 arylation of indazoles
A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: ##STR00001## comprising a copper-catalyzed,...
Processes for the preparation of axitinib
Processes for the preparation of Axitinib in good yield (generally greater than 80%) are provided that avoid the use of a palladium-catalyzed coupling reaction.
Processes for the preparation of pesticidal compounds
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
Substituted azines as pesticides
The invention relates to compounds of the general formula (I), wherein the variable have the meanings as indicated in the claims, or a physiologically...
Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide...
Salt, acid generator, photoresist composition, and method for producing
A salt represented by the formula (I): ##STR00001## wherein R.sup.1 represents a C1 to C12 alkyl group in which a methylene group can be replaced by an oxygen...
Method for producing a substituted benzoic acid compound
To provide an industrial method for producing a substituted benzoic acid compound useful as an intermediate of pharmaceutical and agricultural chemicals with...
Cannabinergic nitrate esters and related analogs
The present technology relates to novel cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods...
Geranyl flavonoid derivative with improved water solubility, a method for
preparing the same, and a method for...
The present invention relates to a novel geranyl flavonoid derivative with improved water-solubility or a pharmaceutically acceptable salt thereof, a method for...
Compounds, compositions, and methods for modulating ferroptosis and
treating excitotoxic disorders
The present invention provides, inter alia, a compound having the structure: (Formula (I). Also provided are compositions containing a pharmaceutically...
Process and apparatus for producing divinylarene dioxide
A process for preparing a divinylarene dioxide including the steps of: (a) feeding one or more feed streams of the following reactants into a reactor system:...
C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and
In its many embodiments, the present invention provides certain C5-spiro iminothiadiazine dioxide compounds, including compounds Formula (I): (structurally...
Compositions of dual thyrointegrin antagonists and use in
A dual thyrointegrin antagonist and a method for treating an angiogenesis-mediated disorder and/or a hyperthyroidism disorders by introducing the dual...
Benzodiazepine derivative and method of producing the same
In a benzodiazepine derivative and a method of producing the derivative, isatoic anhydride or 5-chloroisatoic anhydride is reacted with amino acid ester...
6-substituted quinazolinone inhibitors
The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein...
HIV replication inhibiting pyrimidines
This invention concerns HIV replication inhibitors of formula ##STR00001## the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines...
Saturated acyl guanidine for inhibition of F.sub.1F.sub.0-ATPase
The invention provides saturated acyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using saturated acyl guanidine compounds as...
Indazole compounds as kinase inhibitors and method of treating cancer with
The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are...
Polymorphs and amorphous forms of
The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of ...
Pyrazolyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses
The invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.o-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic...
Biaryl compositions and methods for modulating a kinase cascade
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
Substituted 4-aminocyclohexane derivatives
The invention relates to compounds that have an affinity to the .mu.-opioid receptor and the ORL 1-receptor, methods for their production, medications...
Carbondisulfide derived zwitterions
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be...
Aryloxyurea compound and pest control agent
The present invention provides a pest control agent, acaricide or fungicide that contains, as the active ingredient thereof, at least one type of compound...
Compositions and methods for the treatment of multiple sclerosis
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers,...
p62-ZZ chemical inhibitor
A method for treating a p62-mediated disease (e.g., multiple myeloma) in a subject, the method comprising administering to the subject a therapeutically...
Amine for low-emission epoxy resin products
An amine which can be used in epoxy resin compositions that cure at room temperature. The amine dilutes the composition highly effectively, allows rapid,...
Method for preparing diamino-dicyclohexyl methane
Disclosed is a method for preparing diamino-dicyclohexyl methane (H.sub.12MDA) by hydrogenation of diamino-diphenyl methane (MDA). In the process, 4,4'-MDA used...
Xanthine oxidase inhibitors and methods of use
Small molecule xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by...
Method for post-treating polyol esters
A batchwise process for aftertreatment of polyol esters prepared by reacting polyols of the general formula (II) ...
Process for producing acetic acid by introducing a lithium compound
Process for producing acetic acid is disclosed in which a lithium compound is added to the reaction medium to maintain a concentration of lithium acetate from...
Method for producing unsaturated aldehyde and/or unsaturated carboxylic
Provided is a method of subjecting an alkene to partial oxidation by using a fixed bed multitubular reactor, thereby producing an unsaturated aldehyde and/or an...
Method for producing formic acid by CO.sub.2 hydrogenation
The invention relates to a continuous method for producing formic acid from CO.sub.2 and extracting the formic acid using compressed CO.sub.2.
Method for producing methacrolein and the conditioning/draining thereof
for direct oxidative esterification
The present invention relates to a process for preparing methyl methacrylate by direct oxidative esterification of methacrolein and the preparation of...
Extraction and purification of urushiol from botanical sources
The disclosure relates to methods for preparing urushiol from plants including, for example, poison ivy or poison oak. The methods include extraction of plant...
Pharmaceutical compositions comprising POH derivatives
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol...
Process for simultaneous extraction and separation of esterified and
The present invention is in the field of organic and natural product chemistry. The present invention relates to an efficient process for purification,...
Ethylene recovery by absorption
A process for recovery of ethylene from a polymerization product stream of a polyethylene production system, comprising separating a light gas stream from the...
Landfill gas treatment method with polishing
A method for recovering methane gas from a landfill involves the use of a main absorber, a flash system, an optional ancillary absorber and an optional...
Disclosed herein is a process for dehydrogenating a saturated cyclic hydrocarbon and/or 5-membered ring compound with a dehydrogenation catalyst. The...
Natural gas processing and systems
The present disclosure provides natural gas and petrochemical processing systems including oxidative coupling of methane reactor systems that integrate process...
Continuous mixing reactor and method of use
A continuous mixing reactor has an outer shell having a cylindrical portion with a central section and two opposite conical end sections; a circulation tube...
Process and catalyst for conversion of acetic acid to isobutene and
A process is disclosed for converting acetic acid to propylene and isobutene as the principal hydrocarbon products made, in the presence of a catalyst and in...
Mechanically activated metal fuels for energetic material applications
The invention provides mechanically activated metal fuels for energetic material applications. An exemplary embodiment involves mechanically treating...
Nitrogen-fixing bacterial inoculant for improvement of crop productivity
and reduction of nitrous oxide emission
The present invention relates to methods of reducing chemical fertilizer usage and greenhouse gas nitrous oxide emission and to methods of improving plant...
Coatings for ceramic substrates
A process for making highly mechanical and chemical resistant ceramic substrates, especially tiles is provided, wherein the process comprises coating said...
Preparation method of tungsten carbide sintered body for friction stir
The present invention relates to a preparation method of a tungsten carbide sintered body for a friction stir welding tool used in a friction stir welding tool...