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Patent # Description
US-9,585,887 Modulators of androgen synthesis
The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for...
US-9,585,886 ASK1 inhibiting pyrrolopyrimidine derivatives
This invention relates to pyrrolopyrimidine derivatives of formula (I): where R.sub.1, X, p, R.sub.4, R.sub.2 and R.sub.3 are as defined herein, and their use...
US-9,585,885 Substituted pyrido[2,3-g]quinazolines as dopamine D.sub.2 receptor agonists
[Problem] To provide a novel compound that exhibits an agonistic effect on dopamine D.sub.2 receptors. [Solution] The present invention provides a compound...
US-9,585,884 Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and...
US-9,585,883 Pyrimidinedione compounds
Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy...
US-9,585,882 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula I: ##STR00001## where R.sup.1, R.sup.2a, R.sup.2b, and R.sup.3-R.sup.6 are as defined in...
US-9,585,881 Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are...
US-9,585,880 Cyclic amino compounds for use in the treatment of cardiac disorders
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds...
US-9,585,879 Heterocyclic GSK-3 allosteric modulators
The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme....
US-9,585,878 Treatment of BDNF-related disorders using laquinimod
This application provides for a method of increasing brain-derived neurotrophic factor (BDNF) serum level in a human subject comprising periodically...
US-9,585,877 Methods of maintaining, treating or improving cognitive function
A method of administering an effective amount of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, or a pharmaceutically acceptable salt...
US-9,585,876 Leucine and nicotinic acid reduces lipid levels
Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of...
US-9,585,875 TRPM8 antagonists
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having...
US-9,585,874 Nuclear transport modulators and uses thereof
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the...
US-9,585,873 Angiotensin II receptor antagonist for the prevention or treatment of systemic diseases in cats
A method is described for the treatment of systemic diseases in cats. A composition is administered to a cat, where the composition includes a therapeutically...
US-9,585,872 Clonidine formulations in a biodegradable polymer carrier
Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site,...
US-9,585,871 Method for treating and curing leishmaniosis using fexinidazole
The present invention encompasses methods of using fexinidazole to treat and eliminate and/or cure L. infantum infections in canines.
US-9,585,870 Compositions and methods for improving lactation
The present disclosure relates to the use of pharmaceutical agents to manipulate serotonin in animal mammary glands. Use of the serotonin agents results in...
US-9,585,869 Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel...
Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) ##STR00001## wherein X, Y, Z, R, R.sub.1, R.sub.2, R.sub.3, R'.sub.3 R.sub.4,...
US-9,585,868 Methods and compositions for treating HIV-associated diarrhea
Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient...
US-9,585,867 Cannabinod formulation for the sedation of a human or animal
A method of humanely incapacitating or immobilizing a human or animal by providing a formulation including a cannabinoid rendering a recipient incapacitated or...
US-9,585,866 Personal care compositions with improved hyposensitivity
The present invention provides personal care compositions comprising a carrier and a mixture of essential oil components having specific levels of eucalyptol,...
US-9,585,865 Small molecule modulators of the cold and menthol receptor TRPM8
The present invention relates to the use of compounds which are capable of producing a cooling sensation when they are brought into contact with the human body....
US-9,585,864 Anticancer formulation
This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this...
US-9,585,863 Treatment of cataplexy
The present invention relates to a method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically...
US-9,585,862 Patch containing rivastigmine
The present invention relates to a rivastigmine-containing patch having improved storage stability and proper release property.
US-9,585,861 Method for treating a cancer with a mixed ligand gold(III) complexes as anti-cancer agents
Gold(III) complexes with mixed ligands as anticancer agents. The gold(III) cations are coordinated to bidentate ligands having diamino functional groups: a...
US-9,585,860 Method for treating eczema
A method for treating eczema including the steps of applying an isothiocyanate functional surfactant to an area affected by eczema, wherein the isothiocyanate...
US-9,585,859 Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant...
In various embodiments, the present invention provides methods of lowering triglycerides in subject on statin therapy and having baseline fasting triglycerides...
US-9,585,858 Pharmaceutical composition containing 13 triglycerides, and preparations and use thereof
The present invention relates to a pharmaceutical composition containing 13 compounds: 1,3-diolein, 1-linolein-3-olein, 1,2-diolein, 1-olein-2-linolein,...
US-9,585,857 Methods of treating diseases associated with high-fat diet and vitamin A deficiency using retinoic acid...
This invention relates to pharmaceutical composition and methods of using vitamin A and/or RARB agonist for the treatment or prevention of diseases or...
US-9,585,856 Stable pharmaceutical composition and methods of using same
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or...
US-9,585,855 Use of nitrated lipids for treatment of side effects of toxic medical therapies
The present invention relates to methods of treating the side effects of a toxic medical therapy using nitrated lipids. In particular, the methods comprise the...
US-9,585,854 N-acetyl-L-cysteine for use in in vitro fertilization
The invention relates to a new use of NAC in IVF, in a human or mammalian animal patient. In addition an effective dose regimen of NAC in IVF is proposed.
US-9,585,853 Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular...
US-9,585,852 Agmatine containing dietary supplements, nutraceuticals and foods
The invention is dietary supplements, nutraceutical compositions, medical foods, and animal feeds that have cytoprotective (cell and tissue protection) and...
US-9,585,851 Treatment of conditions through pharmacological modulation of the autonomic nervous system
Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject...
US-9,585,850 Methods of treatment using arylcyclopropylamine compounds
The present invention is directed to a method of treating Parkinson's disease using arylcyclopropylamine compounds. The arylcyclopropylamine compounds have the...
US-9,585,849 Broad spectrum antiviral and methods of use
A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I),...
US-9,585,848 Small molecule xanthine oxidase inhibitors and methods of use
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
US-9,585,847 Small molecule xanthine oxidase inhibitors and methods of use
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
US-9,585,846 Anti-microbial composition
The present invention relates to an anti-microbial composition and method of use thereof. In particular, the present invention relates to an anti-microbial...
US-9,585,845 Oral pharmaceutical composition comprising oseltamivir and method of preparing the same
A pharmaceutical composition, including: an active ingredient-loaded pellet core and a coating layer. The active ingredient of the pellet core is oseltamivir or...
US-9,585,844 Oral pharmaceutical composition
An oral composition comprising minicapsules wherein the minicapsules comprise one or more therapeutic or prophylactic substances in a liquid, semi-liquid, or...
US-9,585,843 Controlled release dosage form
The present invention provides a simple and improved dose form that is capable of providing a controlled release of GABA.sub.B receptor agonist contained in the...
US-9,585,842 Sustained release guanfacine HCL formulation
The present invention is directed to a pharmaceutical composition comprising guanfacine or a salt thereof in nanoparticle form and at least one non-pH dependent...
US-9,585,841 Tyrosine derivatives and compositions comprising them
Provided herein are methods comprising providing a tyrosine derivative and a solid particulate material (and, optionally, melanin) and applying force to said...
US-9,585,840 Redox active cerium oxide nanoparticles and associated methods
Nanoparticles disclosed in the invention comprise a dextran-coated crystalline structure of cerium oxide wherein tetravalent Ce.sup.4+ predominates over...
US-9,585,839 Particles for use in a pharmaceutical composition
The invention provides a method of making a composition for inhalation which includes the step of mixing particles of additive material having a diameter of not...
US-9,585,838 Production of multivesicular liposomes
Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a...
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