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Patent # Description
US-9,586,996 Lytic-peptide-Her2/neu (human epidermal growth factor receptor 2) ligand conjugates and methods of use
The invention relates to conjugates that bind to Her2/neu, methods of using conjugates that bind to Her2/neu and methods of treating undesirable or aberrant...
US-9,586,995 Compositions and methods of use for (pro)renin receptor
Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin...
US-9,586,994 CD44V6-derived peptides for treating breast cancer
The present invention relates to compounds, pharmaceutical compositions and methods for treating different forms of breast cancer.
US-9,586,993 CD44v6-derived peptides for treating pancreatic cancer
Compounds, pharmaceutical compositions and methods for treating different forms of pancreatic cancer.
US-9,586,992 Amidated dopamine neuron stimulating peptides for CNS dopaminergic upregulation
The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or "Amidated...
US-9,586,991 Inhibitors of IAP
Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: ##STR00001## wherein R.sup.1, R.sup.2,...
US-9,586,990 Enzymes for transforming ergopeptines and method therefor
Enzymes for transforming, in particular hydrolytically cleaving, ergopeptines, which ergopeptines are .alpha./.beta.-hydrolases hydrolytically cleaving...
US-9,586,989 Non-toxic skin cancer therapy with copper peptides
Methods are provided for administering compositions for topical dermatological treatment and resolution of skin cancer lesions in humans and domestic animals,...
US-9,586,988 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino...
US-9,586,987 Primer set for isothermal amplication of a target nucleic acid sequence
The present invention provides a primer set including primers that can be designed easily, with which an amplification distance can be shortened. Provided is a...
US-9,586,986 Substituted 7-deazapurine ribonucleosides for therapeutic uses
Compounds of Formula I and a pharmaceutically acceptable salt thereof, an optical isomer thereof, or a mixture of optical isomers thereof, as well as...
US-9,586,985 Organic compounds as proantigens for natural killer T cells
This invention relates to sphingoglycolipid analogs, compositions comprising these compounds, processes for preparing the compounds, and methods of treating or...
US-9,586,984 One-pot synthesis of alpha/beta-O-glycolipids
The present invention provides a one-pot method of preparing an unprotected .alpha.-O-glycolipid. The first step involves contacting a protected .alpha.-iodo...
US-9,586,983 Amphiphilic nanosheets and methods of making the same
In some embodiments, the present invention provides amphiphilic nanosheets that comprise lamellar crystals with at least two regions: a first hydrophilic...
US-9,586,982 Nickel-based complex and use thereof in a method for the oligomerisation of olefins
The invention describes a novel dissymmetric nickel-based complex and the method of preparation thereof from at least one diphosphinamine ligand B1 of formula...
US-9,586,981 Z-selective metathesis catalysts
A novel chelated ruthenium-based metathesis catalyst bearing an N-2,6-diisopropylphenyl group is reported and displays near-perfect selectivity for the Z-olefin...
US-9,586,980 Silane sulfide modified elastomeric polymers
The present invention relates to silane sulfide modifier compounds and methods of making them. The invention also relates to a silane sulfide modified...
US-9,586,979 Amino-silyl amine compound, method for preparing the same and silicon-containing thin-film using the same
Provided are a novel amino-silyl amine compound, a method for preparing the same, and a silicon-containing thin-film using the same, wherein the amino-silyl...
US-9,586,978 Anti-viral compounds
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds,...
US-9,586,977 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in...
US-9,586,975 Macrocyclic salt-inducible kinase inhibitors
The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of...
US-9,586,974 Cyclic N-acyl O-amino phenol CBI derivative
A group of cyclic N-acyl O-amino phenol CBI derivatives were synthesized and shown to be pro-drugs, subject to reductive activation by cleavage of a N-0 bond,...
US-9,586,973 HDAC6 inhibitors and uses thereof
Histone deacetylases 6 (HDAC6) inhibitors and compositions containing the same. Methods of treating diseases and conditions wherein inhibition of HDAC6 provides...
US-9,586,972 Organic thin film transistor, organic semiconductor thin film, and organic semiconductor material
An organic thin film transistor having a semiconductor active layer containing a compound represented by the formula (1) has a high carrier mobility and a small...
US-9,586,971 Green sulfur bacteria variant and bacteriochlorophyll
Provided is a strain permitting genetic engineering of green sulfur bacteria that synthesize bacteriochlorophyll e; isolated green sulfur bacterium...
US-9,586,970 Imidazole derivatives
The present invention relates to compounds of formula (I), wherein A, B, R.sup.1 and R.sup.2 are ##STR00001## as defined herein before useful for the...
US-9,586,969 Microbiocidal heterobicyclic derivatives
Compounds of the formula I wherein Y--X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, A.sup.1, A.sup.2, A.sup.3, Ra and n are as...
US-9,586,968 Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
Disclosed are compounds of Formula A-a, or a salt thereof: Where "B.sup.1" and "R.sup.1" through "R.sup.5" are as defined herein, which compounds have...
US-9,586,967 Pyrrolo pyrimidine derivative
A compound represented by the general formula (1) has a pyridone ring structure introduced into a pyrrolo pyrimidine skeleton, so that the compound has a strong...
US-9,586,966 Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-one
The present invention relates to compounds of general formula I wherein R.sup.1, R.sup.2, R.sup.3 and X are as defined ##STR00001## herein, or to a...
US-9,586,965 Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including...
US-9,586,964 Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the...
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds,...
US-9,586,963 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists
The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical...
US-9,586,962 Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in...
US-9,586,961 Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
The invention relates to compounds of general formula (I) wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, m and n are defined as defined herein, and...
US-9,586,960 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrro- lo[1,2,3-de]...
The present invention relates to toluenesulfonic acid addition salt crystals of 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4': ...
US-9,586,959 Substituted tricyclic heterocycles as histamine 4 receptor inhibitors
The present invention relates to novel heterocyclic compounds of formula 1 useful in preparing drugs for treatment of diseases associated with various functions...
US-9,586,958 Prodrug derivatives of substituted triazolopyridines
The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or...
US-9,586,957 2-keto amide derivatives as HIV attachment inhibitors
Compounds of Formula I, including pharmaceutically acceptable salts thereof: I useful as HIV attachment inhibitors. ##STR00001##
US-9,586,956 Isoquinoline and naphthyridine derivatives
The invention provides novel compounds having the general formula: ##STR00001## wherein A, R.sup.1 and R.sup.2 are as described herein, compositions including...
US-9,586,955 Compounds for treating spinal muscular atrophy
Provided herein are compounds of Formula (I): ##STR00001## and forms thereof, including compositions thereof and uses therewith for treating spinal muscular...
US-9,586,954 N-substituted noribogaine prodrugs
This invention relates generally to prodrugs of noribogaine. This invention also relates to pharmaceutical compositions comprising the prodrugs of noribogaine...
US-9,586,953 Prodrugs of amino quinazoline kinase inhibitor
Disclosed are compounds having the formula: ##STR00001## wherein X is as defined herein, and methods of making and using the same.
US-9,586,952 Polycyclic estrogen receptor modulators and uses thereof
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
US-9,586,951 Morpholine derivative or salt thereof
There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof ##STR00001## (In the formula, a ring A represents a ring...
US-9,586,950 2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists
The present invention is directed to 2-pyridyloxy-3-ester-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed...
US-9,586,949 Aza-heteroaryl compounds as PI3K-gamma inhibitors
The present invention provides aza-heteroaryl derivatives of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W,...
US-9,586,948 Inhibitors of IRAK4 activity
The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for...
US-9,586,947 Imidazoline derivatives, preparation methods thereof, and their applications in medicine
New imidazoline derivatives represented by formula (I): ##STR00001## preparation methods thereof, pharmaceutical compositions comprising such derivatives, and...
US-9,586,946 Selective immunoproteasome inhibitors with non-peptide scaffolds
Compounds useful for inhibiting the immunoproteasome have the formula of ##STR00001## Methods and compounds for inhibiting the immunoproteasome, particularly,...
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