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Patent # Description
US-9,586,945 Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions...
The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) ##STR00001## or a...
US-9,586,944 Specific targeting of RNA expanded repeat sequences
The present invention provides small molecule compounds that can form covalent adducts with specific sequences of RNA, such as the hairpin loop r(CUG).sup.exp...
US-9,586,943 Bilaterally-substituted tricyclic compounds for the treatment of human immunodeficiency virus type-1 (HIV-1)...
The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their...
US-9,586,942 Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
The present invention relates to aminotetraline and aminoindane derivatives of the formula (I) ##STR00001## or a physiologically tolerated salt thereof. The...
US-9,586,940 Methods for treatment of breast cancer nonresponsive to trastuzumab
The present invention provides a method of treating breast cancer that is nonresponsive to treatment with trastuzumab, comprising administering to a subject in...
US-9,586,939 Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof
The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as...
US-9,586,938 Cyclic amine azaheterocyclic carboxamides
The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the...
US-9,586,937 sGC stimulators
Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds...
US-9,586,936 Heteroarylamine derivatives as protein kinase inhibitors
A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for...
US-9,586,935 Urazole compounds
The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) wherein R.sup.1, R.sup.2, R.sup.3,...
US-9,586,934 2-pyridyloxy-4-methyl orexin receptor antagonists
The present invention is directed to 2-pyridyloxy-4-methyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
US-9,586,933 Processes for preparing ASK1 inhibitors
The present disclosure provides processes for the preparation of a compound of formula: ##STR00001## which exhibits apoptosis signal-regulating kinase...
US-9,586,932 Apoptosis signal-regulating kinase inhibitors
The present invention relates to compounds of Formula (I): ##STR00001## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4, X.sup.5, X.sup.6, X.sup.7, X.sup.8,...
US-9,586,931 Triazolyl derivatives as Syk inhibitors
Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives...
US-9,586,930 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The...
US-9,586,929 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same
Provided are quinazolinone compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and...
US-9,586,928 Modulators of the nuclear hormone receptor ROR
The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as ROR.alpha., ROR.beta., or ROR.gamma., of formula ...
US-9,586,927 Method for continuously producing cyclic carbonate
Provided is a method for continuously producing a cyclic carbonate, by which generation of a glycol in a reaction for synthesizing a cyclic carbonate is...
US-9,586,926 Methods of making alkylene carbonates and methods of converting CO.sub.2
Embodiments of the present disclosure provide for a method of making an alkylene carbonate, catalysts, methods of converting CO.sub.2 to an alkylene carbonate,...
US-9,586,925 1-(dimethylamino)ethyl-substituted 6H-benzo[C]chromen-6-ones against senile dementia
This invention relates to novel (.+-.)1-(Dimethylamino)ethyl substituted 6H-benzo[c]chromen-6-one compounds which are useful as pharmaceutical compositions.
US-9,586,924 Organic compound, light-emitting element, light-emitting device, electronic appliance, and lighting device
An organic compound that emits blue light with high color purity and has a long lifetime is provided as a novel substance. The organic compound is a fluorescent...
US-9,586,923 Spray oxidation process for producing 2,5-furandicarboxylic acid from hydroxymethylfurfural
A process is provided for carrying out an oxidation on a sprayable feed including a furanic substrate to be oxidized and a catalytically effective combination...
US-9,586,922 Methods for purifying 5-(halomethyl)furfural
The present disclosure provides methods for purifying a 5-(halomethyl)furfural composition, including 5-(chloromethyl)furfural, at operating conditions that...
US-9,586,921 Burdock fruit extract containing arctigenin at high content and process for producing same
PROBLEM TO BE SOLVED A burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for...
US-9,586,920 Process for production of hexanetriol from 5-hydroxymethylfurfural
Industrial scale conversions of 5-hydroxymethylfurfural to commodity chemicals such as 1,2,6-hexanetriol and 1,6-hexanediol by chemocatalytic conversions using...
US-9,586,919 Crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
The present invention relates to a new anhydrous crystalline form of Cabazitaxel of formula (I), designated as form H. A further object of the present invention...
US-9,586,918 Unsaturated fatty acid ester-based compositions useful as plastic additives
Compositions useful as plastic additives may be prepared from renewable resources such as vegetable oils by functionalizing an unsaturated fatty acid ester with...
US-9,586,917 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for...
A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost,...
US-9,586,916 Integrin antagonist conjugates for targeted delivery to cells expressing alpha-V-beta-3
The invention relates to compounds of formula (I): wherein R.sup.1, R.sup.2, and n are defined in the detailed description and claims. In particular, the...
US-9,586,915 Multifunctional composition base 1,3-oxazinan-6-ones with corrosion inhibition and heavy organic compounds...
Base compounds including 1,3-oxazinan-6-one derivatives of N-alkyl or N-alkenyl or N-cycloalkyl or N-aryl propionic acids and paraformaldehyde, and their...
US-9,586,914 Modulators of C3a receptors
Heterocyclic compounds that modulate C3a receptors and their use in the treatment or prevention of inflammatory diseases, infectious diseases, cancers,...
US-9,586,913 Processes for the preparation of linezolid using novel intermediates
Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of Linezolid, in high yield and purity, using...
US-9,586,912 2-substituted-2H-1, 2, 3-triazole derivative and its preparation method
Disclosed is a 2-substituted-2H-1,2,3-triazole derivative, a compound as represented by formula I or II. Also disclosed is a preparation method of the compound...
US-9,586,911 Arylalkyl- and aryloxyalkyl-substituted epthelial sodium channel blocking compounds
The present invention relates to the compound of the formula: ##STR00001## or pharmaceutically acceptable salts thereof, as well as compositions containing the...
US-9,586,910 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amin- ...
The present invention relates to the compound of the formula: ##STR00001## or pharmaceutically acceptable salts thereof, as well as compositions containing the...
US-9,586,909 Compound of synthetic intermediate
Provided is a 5,6-diaryl-2-pyrazyl triflate, its synthetic method, and a method for synthesizing an organometallic complex having a triarylpyrazine ligand from...
US-9,586,908 2,4-pyrimidinediamine compounds and their uses
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical...
US-9,586,907 Isothiocyanate compounds, pharmaceutical compositions, and uses thereof
Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including...
US-9,586,906 Method of working up mixtures comprising imidazolium salts
Method of lightening the color of mixtures comprising imidazolium salts or imidazoles, wherein the mixtures are treated with an oxidant.
US-9,586,905 Benzoazepine derivative and medical use thereof
A compound having a V2 receptor agonistic activity is provided. Providing a pharmaceutical composition which contains, as an active ingredient, a compound...
US-9,586,904 Preparation of (-)-huperzine A
The present invention relates to a method for preparing (-)-huperzine A. The method involves: allowing a mixture of (.+-.)-huperzine A obtained from chemical...
US-9,586,903 Isoquinoline derivatives
The present invention relates to the use of compounds of general formula ##STR00001## wherein R.sup.1 is phenyl or pyridinyl, which are optionally substituted...
US-9,586,902 Histone demethylase inhibitors
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
US-9,586,901 Lactams
Lactams of formulae (I) and (II) and their use in the treatment of microbial infections and microbial contamination of surfaces, particularly infections and...
US-9,586,900 Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These...
US-9,586,899 Synthetic process for aminocyclohexyl ether compounds
Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or...
US-9,586,898 Oxidation of cyclohexylbenzene
In a process for oxidizing a feed comprising cyclohexylbenzene, the feed is contacted with oxygen and an oxidation catalyst in a plurality of reaction zones...
US-9,586,897 Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of ...
US-9,586,896 Nitroxyl donors with improved therapeutic index
The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and...
US-9,586,895 Dimethylsulfoxide preparation method
A process for producing dimethyl sulfoxide, wherein said process comprises the following steps: (1) contacting hydrogen sulfide with methanol to produce a...
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