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Patent # Description
US-9,593,379 Composition and kit for diagnosing breast cancer including polynucleotide within vesicle, and method of...
A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the...
US-9,593,378 BCR-ABL1 splice variants and uses thereof
The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the bcr-abl1 transcript and the finding that these...
US-9,593,377 Signatures and determinants associated with cancer and methods of use thereof
The present invention provides methods of detecting cancer using biomarkers.
US-9,593,376 Natural killer p30 (NKp30) dysfunction and the biological applications thereof
The present invention relates to a method of assessing a favorable or, on the contrary, an unfavorable prognosis of a cancer in the subject, which method...
US-9,593,375 Nucleic acid analysis using emulsion PCR
The present invention provides methods for analyzing large nucleic acids including chromosomes and chromosomal fragments. In one aspect, the present invention...
US-9,593,374 Composition and method for determination of CK19 expression
Disclosed is a method for quantitative determination of CK-19 mRNA positive cells in a biological sample. The method can be used, for instance, with peripheral...
US-9,593,373 Modified nucleosides or nucleotides
Some embodiments described herein relate to modified nucleotide and nucleoside molecules with novel 3'-hydroxy protecting groups. Also provided herein are...
US-9,593,372 Nanopore based sequencer
The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such...
US-9,593,371 Integrated photonic electronic sensor arrays for nucleic acid sequencing
Devices and methods for detecting, identifying, and sequencing, compounds, complexes, and molecules are described. Electronic detection is combined with optical...
US-9,593,370 Biochemical analysis apparatus and rotary valve
An analysis apparatus for performing biochemical analysis of a sample using nanopores comprises: a sensor device that supports plural nanopores, reservoirs...
US-9,593,369 Direct nucleic acid analysis
The present disclosure provides methods, systems, and apparatuses for collecting and/or amplifying nucleic acids. In general, provided methods, systems, and...
US-9,593,368 Methods for amplifying nucleic acids on substrates
A method is provided herein, the method includes: applying a sample comprising target nucleic acids to a sample application zone of a substrate; applying an...
US-9,593,367 Genetic test system
There is provided a genetic test system provided with a dispensing means for dispensing a sample and a reagent to a reaction vessel and a vessel conveyance...
US-9,593,366 Individually synthesized primers to be used in whole genome amplification
Disclosed are compositions and methods for random amplification of nucleic acid sequences of interest using random-G-deficient primers. Also disclosed are...
US-9,593,365 Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
The present invention relates to methods and products for localized or spatial detection and/or analysis of RNA in a tissue sample or a portion thereof,...
US-9,593,364 Detecting a target molecule in a sample using a dual-antibody quantitative fluorescence-based detection method
A kit and method for detection of a target in a sample. An assay mixture provided in the kit and used in the method includes a first probe with a first antibody...
US-9,593,363 Methods and models for assessing anti-aging benefits of agents
A screening method for identifying an agent as effective for providing an anti-aging skin benefit is provided. The screening method includes culturing first and...
US-9,593,362 Fluorogenic glycosidase substrate and associated detection method
The invention concerns novel glycosidase substrates of formula (I): ##STR00001## where R.sub.0, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are such as defined in...
US-9,593,361 Salmonella detection articles and methods of use
An article for detecting Salmonella microorganisms is provided. The article comprises a highly selective nutrient medium and a plurality of indicator systems. A...
US-9,593,360 Measurement of brain CDP-diacylglycerol synthase 1 enzyme and uses thereof
Provided herein are methods of diagnosing depressive disorders in a subject by comparing a CDP-diacylglycerol synthase 1 enzyme activity or expression level to...
US-9,593,359 Liquid to liquid biological particle concentrator with disposable fluid path
Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a...
US-9,593,358 Method and medium for detecting Shiga toxin-producing Escherichia coli bacteria
The present invention relates to a method for specific and direct detection of Shiga toxin-producing Escherichia coli bacteria in a sample using a selective and...
US-9,593,357 Process to control CO concentrations in fermentations
A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process...
US-9,593,356 Protein enriched microvesicles and methods of making and using the same
Protein enriched micro-vesicles and methods of making and using the same are provided. Aspects of the methods include maintaining a cell having a ...
US-9,593,355 Process for the production of optimised liquefied lignocellulosic substrate
The present invention concerns a production of liquefied lignocellulosic substrate by enzymatic reaction. 10% to 40% by weight dry matter of pre-treated...
US-9,593,354 Method for producing L-lysine using microorganisms having ability to produce L-lysine
The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1;...
US-9,593,353 Microorganisms for production of O-succinylhomoserine and method for production of O-succinylhomoserine using...
The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a...
US-9,593,352 Production of fatty acid alkyl esters by use of two lipolytic enzymes
A method for producing fatty acid alkyl esters, wherein a solution comprising triglyceride and alcohol is contacted with a first lipolytic enzyme having a...
US-9,593,351 Recombinant microalgae including sucrose invertase and thioesterase
Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the...
US-9,593,350 Lactate dehydrogenase mutant, polynucleotide coding for the mutant, yeast cell including the polynucleotide,...
A lactate dehydrogenase mutant, a polynucleotide encoding the mutant, a recombinant yeast cell including the polynucleotide, and a method of preparing the...
US-9,593,349 Fermentative production of alcohols
The invention relates to the development of microorganisms capable of producing fermentation products via an engineered pathway in the microorganisms. The...
US-9,593,348 System and method for continuous enzyme addition to a fermentation process
A method for controlling a fermentation process includes injecting a mash into a fermenter and injecting an enzymatic additive into the fermenter on a...
US-9,593,347 Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector...
The invention provides modified HSV vectors that exhibit enhanced entry of cells, either through direct infection and/or lateral spread. In one aspect, HSV...
US-9,593,346 Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50, and uses thereof
A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A...
US-9,593,345 Bacillus thuringiensis gene with coleopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having...
US-9,593,344 Enhanced triacylglycerol accumulation in vegetative tissues of plants
In the tgd1-1 mutant that displays substantially enhanced TAG synthesis and turnover, disruption of SUGAR-DEPENDENT1 (SDP1) TAG lipase or PEROXISOMAL...
US-9,593,343 Plant variant, method for producing plant variant, and method for accumulating soluble sugar
This invention is intended to allow accumulation of large quantities of soluble sugars in tissue other than plant seeds. A plant is modified so as to suppress a...
US-9,593,342 Methods for producing polypeptides in enzyme-deficient mutants of Fusarium venentatum
The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent Fusarium venenatum strain in a medium for...
US-9,593,341 Filamentous fungi having an altered viscosity phenotype
Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in...
US-9,593,340 Expression system for modulating an immune response
The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response...
US-9,593,339 Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
The present invention uses co-expression of protease inhibitors and protease sensitive therapeutic agents including phage and phagemids delivering peptides,...
US-9,593,338 Synthetic transcriptional control elements and methods of generating and using such elements
Provided herein are nucleic acid constructs that contain a synthetic control element that includes a cis-regulator of translation, and an adapter...
US-9,593,337 Method for identifying biologically active oligonucleotides capable of modulating the immune system
The present invention relates to methods of identifying oligonucleotides capable of modulating the immune system in a mammalian subject, comprising analysis of...
US-9,593,336 Compositions and methods for treating cancer and other diseases
Aptamers and improved aptamers are provided with enhanced efficacy for binding to target molecules in vivo or for treating cancer or other diseases. Such...
US-9,593,335 Small interference RNAs, uses thereof and method for inhibiting the expression of PLK1 gene
The present invention provides siRNAs for inhibiting the expression of plk1 gene, and the method for inhibiting the expression of plk1 gene in mammalian cells....
US-9,593,334 Use of the chromosome 19 microRNA cluster (C19MC) for treating viral disease and promoting authophagy
It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and...
US-9,593,333 Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
Provided are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein for treating, preventing, delaying, or ameliorating...
US-9,593,332 Methods and compositions for targeting immunoglobulins
The present invention relates to compositions and methods for targeting immunoglobulins and immunoglobulin-producing plasma cells. In particular, the present...
US-9,593,331 Double-stranded nucleic acid molecule for gene expression control
Provided are an improved double-stranded nucleic acid molecule involved in gene expression control mediated by a gene silencing mechanism, a method of producing...
US-9,593,330 Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Frataxin (FXN), in particular, by targeting...
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