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Patent # Description
US-9,593,127 Heterocyclylalkyne derivatives and their use as modulators of mGluR5 receptors
This invention relates to compounds of formula I, ##STR00001## their use as allosteric modulators of mGluR5 receptor activity, pharmaceutical compositions...
US-9,593,126 Synthesis of spirocyclic isoxazoline derivatives
The invention recites an improved process for preparing spirocyclic isoxazoline derivatives of Formula (1) wherein "*", R.sup.1a, R.sup.1b, and R.sup.1c are as...
US-9,593,125 Heterocyclic flavone derivatives, compositions, and methods related thereto
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical...
US-9,593,124 Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine...
US-9,593,123 Triazolo[4,5-D]pyrimidine derivatives
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of...
US-9,593,122 Substituted pyrazolylpyrazole derivative and use of same as herbicide
Provided is a compound capable of effectively control worst weeds of higher leaf stages that present practical problems. A specific pyrazolylpyrazole derivative...
US-9,593,121 Indole substituted pyrrolopyrimidinyl inhibitors of Uba6
Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*.sup.1 is...
US-9,593,120 Paralytic shellfish poison
The invention concerns a paralytic shellfish poison for the treatment of itching in a human being or another mammal.
US-9,593,119 Process for the preparation of dipeptidylpeptidase inhibitors
The present invention provides a process for the preparation of linagliptin, a compound of Formula I, the process comprising deprotecting a compound of Formula...
US-9,593,118 Xanthine-substituted alkynyl carbamates/reverse carbamates as A.sub.2B antagonists
The present invention provides xanthine-substituted alkynyl carbamates/reverse carbamates and derivatives thereof and pharmaceutical compositions containing the...
US-9,593,117 Crystalline form of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-- ...
Crystalline form, Form HI.5-4, of N,N-di-cyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl- ...
US-9,593,116 Crystalline forms of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-- ...
Crystalline form, Form T1H1.5-4, of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl ...
US-9,593,115 Substituted fused tricyclic compounds, compositions, and medicinal applications thereof
The present invention relates to substituted fused tricyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates,...
US-9,593,114 Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives
The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated ...
US-9,593,113 Imide and acylurea derivatives as modulators of the glucocorticoid receptor
Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1,...
US-9,593,112 Substituted pyrazolylpyrazole derivative and use of same as herbicide
Provided is a compound capable of effectively control worst weeds of higher leaf stages that present practical problems. A specific pyrazolylpyrazole derivative...
US-9,593,111 Oxidative dearomatization of berbines
The present disclosure provides oxidized berbine derivatives, processes for their preparation, and methods of using the oxidized berbine derivatives.
US-9,593,110 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula I: ##STR00001## where R.sup.1-R.sup.6 are as defined in the specification, or a...
US-9,593,109 Bicyclic agonists of GPR131 and uses thereof
The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various...
US-9,593,108 Compounds and methods for antiviral treatment
The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral...
US-9,593,107 Dihydroquinoline-2-one derivatives
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7,...
US-9,593,106 Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists
The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R.sup.2 and...
US-9,593,105 Cyclic amines
The present invention is directed to novel cyclic amines which inhibit the P2X.sub.7 receptor.
US-9,593,104 Process for the preparation of oxazolidinone derivatives
The present invention relates to an improved process for the preparation of Oxazolidinone derivatives. More specifically, the present invention relates to an...
US-9,593,103 Pyridyl hydrazones for the treatment of tuberculosis and related diseases
The invention provides pyridyl-hydfazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isprriers and prodrugs thereof as well as...
US-9,593,102 Piperidine compounds, pharmaceutical composition comprising the same and its use
Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically...
US-9,593,101 Avanafil preparation method
Disclosed is a method for preparing avanafil (I) by using cytosine as the starting material. The preparation steps comprise: using cytosine as the raw material,...
US-9,593,100 Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent...
US-9,593,099 Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent...
US-9,593,098 Compounds and compositions for modulating EGFR mutant kinase activities
The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are...
US-9,593,097 Axl inhibitors
Compounds of the general formula (I): ##STR00001## processes for the preparation of these compounds, compositions containing these compounds, and the uses of...
US-9,593,096 .alpha.7 nicotinic acetylcholine receptor modulators and uses thereof-III
The present invention relates to chemical compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (.alpha.7 nAChR).
US-9,593,095 Methods for the treatment of bacterial infections
This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method...
US-9,593,094 Liquid crystal medium, optical device, and liquid crystal compound
A liquid crystal medium having stability to heat, light and so forth, a wide liquid crystal phase temperature range, a low driving voltage and a small...
US-9,593,093 Methods for the manufacture of acetals and ketals, and the acetals and ketals produced thereby
A method for producing a product that comprises glycerol ketal of ethyl levulinate or propylene glycol ketal of ethyl levulinate comprises reacting either...
US-9,593,092 Pyran derivatives, their preparation and use thereof in perfumery
A process of preparing a compound of formula (I) wherein R represents a linear or branched C5 alkyl group, as well as the use of such compounds in a fragrant...
US-9,593,091 Methods for making epoxidized fatty acid alkyl esters
Methods for making epoxidized fatty acid alkyl esters. Such epoxidized fatty acid alkyl esters can be prepared by epoxidizing a natural oil with an acid and a...
US-9,593,090 Alkylene oxide separation systems, methods, and apparatuses
A propylene oxide separation system that comprises a distillation column, a decanter, and water wash system. The distillation column is configured to receive a...
US-9,593,089 Process for preparing TDI isocyanurate
The present invention relates to a method for preparing TDI (toluene diisocyanate) isocyanurate by using TDI, monohydric alcohol, solvent, antioxidant, catalyst...
US-9,593,088 Method for producing a polymerizable UV absorber
The present invention relates to a two-stage preparation process for an organic UV absorber that has a (meth)acrylate group in the molecule and which as a...
US-9,593,087 Materials for organic electroluminescent devices
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent...
US-9,593,086 Process for the preparation of deferasirox
Present disclosure discloses the commercially viable process for the preparation of Deferasirox and its polymorph with. Disclosed process involves the...
US-9,593,085 Blue luminescent compounds
There is provided a compound having Formula I ##STR00001## In the formula: R.sup.1 can be alkyl, aryl, alkylaryl, or deuterated analogs thereof; R.sup.2 can...
US-9,593,084 Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
This invention provides compounds of the formula I: ##STR00001## and their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions...
US-9,593,083 Crystalline erlotinib hydrochloride process
The present invention provides process for preparation of Crystalline Erlotinib HCl (I) Form-SE ##STR00001## characterized by X-ray powder diffraction pattern...
US-9,593,082 Compositions and methods for inhibition of the JAK pathway
The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation...
US-9,593,081 4-alkynyl imidazole derivative and medicine comprising same as active ingredient
There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof; the derivatives...
US-9,593,080 Triazabutadienes as cleavable cross-linkers
Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with click chemistry, e.g., clickable triazabutadienes. For example, in...
US-9,593,079 Stabilized multi-functional antioxidant compounds and methods of use
Disclosed are novel stable compounds having anti-oxidant properties and methods of using the compounds for the treatment of diseases or injuries associated with...
US-9,593,078 Crystal forms
The present invention features crystalline forms of Compound I. In one embodiment, a crystalline form of Compound I has characteristic peaks in the PXRD pattern...
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