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Patent # Description
US-9,597,355 Cell culture cassettes and incubator
The invention relates to cassettes for culturing cells. The invention also relates to analytical and preparative incubators for housing the cassettes. The...
US-9,597,354 Sodium nitrite-containing pharmaceutical compositions
Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the...
US-9,597,353 Redox signaling gel formulation
Formulations containing reactive oxygen species (ROS), processes for making these formulations, and methods of using these formulations are described. The...
US-9,597,352 Compositions and methods for treating pain
In the present invention, Applicants demonstrate the effect of a biomembrane sealing agent on the development of chronic pain following tissue injury as well as...
US-9,597,351 Nano-targeted delivery of protease, polymerase inhibitors with or without immune modulators in the treatment of...
This disclosure concerns novel formulation and Nanoformulations as defined in the specification and compositions comprising combination of HCV protease and...
US-9,597,350 Composition comprising at least one alginate for use in treatment and/or prevention of overweight
The present invention relates to a composition in the form of a powder or a viscous paste, and which includes at least one low viscosity alginate having a...
US-9,597,349 Combination of an oxidant and a photoactivator for the healing of wounds
There is provided a wound healing composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant and at least...
US-9,597,348 Method of treating leukemia
The present invention relates to methods of treating disorders in which DOT1L-mediated protein methylation plays a part, such as cancer, by administering DOT1L...
US-9,597,347 Compositions for treating obesity and insulin resistance disorders
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance...
US-9,597,346 Methods for reducing protein levels in a cell
The present invention provides a method of reducing levels of at least one target protein in a cell. The cell is contacted with a first agent and a second...
US-9,597,345 Kit-in-parts for cleaning and treating ears of companion animals
The invention relates to a kit-in-part comprising of a composition for the use as a cleaning and treating of ears of a companion animal and suitable packaging...
US-9,597,344 Sonosensitive liposome, pharmaceutical composition including the same, and method of delivering active agent to...
Provided is a liposome comprising a lipid bilayer and a sonosensitizer that is disposed in and/or on the lipid bilayer, wherein the sonosensitizer...
US-9,597,343 Targeted therapeutics
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a...
US-9,597,342 GABAergic receptor subtype selective ligands and their uses
Described herein are .alpha.3 or .alpha.2 or .alpha.2/.alpha.3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of...
US-9,597,341 Phosphate compounds, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I): ##STR00001## wherein X, Y, A.sub.1, A.sub.2, R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.3, R.sub.4, T and R.sub.5 are as defined in...
US-9,597,340 Cannabinoid receptor modulators
Provided are certain methods useful in the treatment of cancer comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that...
US-9,597,339 Compositions and methods for the treatment of neurodegenerative and other diseases
In one embodiment, the present application discloses methods of treating diseases and disorders with sulfasalazine and pharmaceutical formulations of...
US-9,597,338 Shell-and-core dosage form approaching zero-order drug release
Drugs are formulated as oral dosage forms for controlled release in which the release rate limiting portion is a shell surrounding the drug-containing core. The...
US-9,597,337 Berberine-ursodeoxycholic acid conjugate for treating the liver
The present invention is a method and compound for treating specific cancerous cell lines. The invention treats liver cancer by directing a cancer-fighting drug...
US-9,597,336 Therapy for treatment of chronic degenerative brain diseases and nervous system injury
In one aspect, the present invention provides neuroactive steroids for use in the treatment of nervous system disorders, degenerative brain diseases and...
US-9,597,335 Use of testosterone and a 5-HT1A agonist in the treatment of sexual dysfunction
The invention relates to the field of male and/or female sexual dysfunction. The invention specifically relates to the use of testosterone and a 5-HT1A agonist.
US-9,597,334 Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions,...
Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a...
US-9,597,333 Benzazepine dicarboxamide compounds
This invention relates to novel benzazepine dicarboxamide compounds of the formula ##STR00001## wherein R.sup.1 to R.sup.4 are as defined in the description...
US-9,597,332 Sulfide alkyl compounds for HBV treatment
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the...
US-9,597,331 Therapeutic compositions containing macitentan
The invention relates to a product containing the compound of formula (I) below or a pharmaceutically acceptable salt of this compound, in combination with at...
US-9,597,330 Drugs for treating respiratory diseases
It is intended to provide a therapeutic agent and/or a preventive agent for a respiratory disease or a therapeutic agent and/or a preventive agent for a sodium...
US-9,597,329 Aurora kinase inhibitors and methods of making and using thereof
Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are...
US-9,597,328 Methods and compositions for treating dry eye disease and other eye disorders
The present invention discloses pharmaceutical preparations for treatment of eye disorders containing an alpha 2 adrenergic agonist, to processes for producing...
US-9,597,327 Synthesis of (R)-N-methylnaltrexone
This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof...
US-9,597,326 Benzonapthyridine compositions and uses thereof
The present invention generally relates to compositions comprising benzonapthyridine small molecule immune potentiators (SMIPs) that are capable of stimulating...
US-9,597,325 Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present...
US-9,597,324 Treatment of CNS disorders associated with mutations in genes encoding lysosomal enzymes
Described is a method for treating an individual having a neurological disorder with an associated mutation or mutations in a gene encoding a lysosomal enzyme....
US-9,597,323 Aminoester derivatives
Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating...
US-9,597,322 Otamixaban for use in the treatment of non-ST elevation acute coronary syndrome in patients planned to undergo...
The invention relates to otamixaban or a pharmaceutically acceptable salt thereof for use in the treatment of non-ST elevation acute coronary syndrome in...
US-9,597,321 Antifibrotic compounds and uses thereof
The present invention provides compounds having the general structural formula (I) ##STR00001## and pharmaceutically acceptable derivatives thereof, as...
US-9,597,320 Treatment of pancreatic and related cancers with 5-acyl-6,7-Dihydrothieno[3,2-C]pyridines
Methods for inhibiting the growth of pancreatic cancer cells or other cancer cells driven by Sonic hedgehog are disclosed. The method involves exposing the...
US-9,597,319 Compositions and methods of inhibiting metallo-.beta.-lactamases
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one...
US-9,597,318 2-oxothiazole compounds and method of using same for chronic inflammatory disorders
The invention provides compounds of formula (I) ##STR00001## wherein X is O or S; R.sub.1 is H, OH, SH, nitro, NH.sub.2, NHC.sub.1-6alkyl, ...
US-9,597,317 Substituted indazole derivatives active as kinase inhibitiors
The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases...
US-9,597,316 Indole compounds for use in treating inflammation and cancer
Provided herein are compounds, comprising Formula (I) or Formula (II), and their pharmaceutically acceptable salts. Also provided are pharmaceutical...
US-9,597,315 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
The invention provides novel 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as...
US-9,597,314 Beta-lactamylalkanoic acids for treating premenstrual disorders
0-lactamyl alkanoic acids are described. Methods for treating various premenstrual disorders using or more .beta.-lactamyl alkanoic acids are also described.
US-9,597,313 Composition and methods for the enterosorption and management of toxins
A composition and method for use as a preventive therapy to mitigate the effects of environmental toxins, and particularly aflatoxins in a subject. The subject...
US-9,597,312 Treatment of cognitive disorders associated with abnormal dendritic spines using PKC activators
The present disclosure provides methods of treating a cognitive disorder associated with abnormal dendritic spines, such as Fragile X Syndrome, Fragile X...
US-9,597,311 Suppression and prevention of tumors
Combinations of betaine and vitamin C are used to suppress or prevent malignant tumors, e.g., by combining the two ingredients in a product consumed by a human,...
US-9,597,310 Indanyloxydihydrobenzofuranylacetic acids
The present invention relates to compounds of general formula I, ##STR00001## wherein the groups (Het)Ar and R.sup.1 are defined as in claim 1, which have...
US-9,597,309 Methods of treating renal disease and other disorders
The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low...
US-9,597,308 N-acetyl L-cysteine chelates and methods for making and using the same
A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to zinc to form a chelate ring. A method...
US-9,597,307 Sulforaphane for treating or reducing insulin resistance of the liver
The present invention provides sulforaphane, or a plant extract comprising sulforaphane, for treating or reducing insulin resistance of the liver. Especially,...
US-9,597,306 Fumarate compounds, pharmaceutical compositions thereof, and methods of use
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for...
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