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Patent # Description
US-9,598,460 Antibody purification via affinity chromatography
Embodiments herein provide methods of purifying monoclonal and polyclonal antibodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell...
US-9,598,459 Pharmaceutical compositions and methods
This invention relates the use of cortisol blockers (e.g., glucocorticoid receptor [GR] antagonists) for the treating or preventing viral infections, treating...
US-9,598,458 Asymmetric auxiliary group
To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G.sup.1 and G.sup.2 are independently...
US-9,598,457 Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection...
US-9,598,456 Modified cytosine polynucleotide oligomers and methods
Disclosed are modified cytosine bases that provide enhanced base-pairing affinity for guanine bases in polynucleotide hybridization complexes. Also disclosed...
US-9,598,455 Modified thymine polynucleotide oligomers and methods
Disclosed are modified thymine bases that provide enhanced base-pairing affinity for adenine or 2,6-diaminopurine bases in polynucleotide hybridization...
US-9,598,454 Mannose derivatives for treating bacterial infections
The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: ##STR00001## The...
US-9,598,453 Functionalization and purification of molecules by reversible group exchange
Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups,...
US-9,598,452 Cellulose hydrolysis via modified lignosulfonate catalysts
Biopolymer catalysts, methods of synthesizing a biopolymer catalyst, and methods of catalyzing the hydrolysis of cellulose with a biopolymer catalyst are...
US-9,598,451 Bis-organometallic 2-amino-3-hydroxy-2-methylpropanenitrile derivatives for use as anthelmintics
The invention comprises a compound characterized by a general formula (1), ##STR00001## wherein X is a group described by a general formula ...
US-9,598,450 Emissive compounds for organic light-emitting diodes
Disclosed herein are compounds containing an optionally substituted (2-phenylpyridinato-N,C.sup.2')(2,4-pentanedionato)Pt(II). Some embodiments provide a...
US-9,598,449 Pyridine-oxyphenyl coordinated iridium (III) complexes and methods of making and using
Iridium (III) complexes are described together with methods to prepare and use such complexes. Also described are devices that utilize the iridium (III) complexes.
US-9,598,448 Osmium (II) arene imino anti-cancer complexes
The present invention relates to the use of certain osmium containing complexes such as cytotoxic agents particularly for the treatment of cancer. There is also...
US-9,598,447 Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
The disclosure relates to Phosphorus-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I): ##STR00001## and pharmaceutically acceptable...
US-9,598,446 Amino compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-9,598,445 Methods for producing functionalized graphenes
Methods for producing functionalized graphene from graphite oxide or graphite are disclosed in which ionic liquids are used as a reaction medium to promote...
US-9,598,444 Transition metal complexes of tridentate dianionic CNN ligands, production and use thereof
New pyridylamide transition metal complex compositions for olefin polymerizations are described herein featuring a 7-membered chelate ring and a cyclometalated...
US-9,598,443 Boron containing small molecules as antiprotozoal agents
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as...
US-9,598,442 Crystallized hybrid solid having a three-dimensional DMOF-1-N.sub.3 organic-inorganic matrix and method for...
A crystallized hybrid solid with an organic-inorganic matrix, of three-dimensional structure, containing an inorganic network of zinc-based metal centers...
US-9,598,441 Therapeutic compounds and methods
The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I,...
US-9,598,440 Inhibitors of IRAK4 activity
The present invention relates to compounds which modulate interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or...
US-9,598,439 Purification of rapamycin derivatives using temperature induced phase separation
The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also...
US-9,598,438 Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the...
Described herein are modified sugar, iminosugar and azasugar compounds and methods of making same. One or more of these modified compounds contain sulfates,...
US-9,598,437 Gamma secretase modulators
Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein each of the substituents is given the definition as set...
US-9,598,436 Substituted bicyclic heteroaryl compounds
Disclosed are azaindazole compounds of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is...
US-9,598,435 Fused heterocyclic compounds as ion channel modulators
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
US-9,598,434 Benzazepine compound
Provided is a compound which is useful as an agent for treating or preventing 5-HT.sub.2C receptor-related diseases, particularly incontinence such as stress...
US-9,598,433 Hepatitis C virus inhibitors
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit...
US-9,598,432 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents
The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the...
US-9,598,431 Compounds useful for inhibiting ROR-gamma-t
The present invention provides novel ROR gamma-t inhibitors and pharmaceutical compositions thereof: ##STR00001##
US-9,598,430 GLP-1 receptor modulators
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic...
US-9,598,429 Method for synthesizing Milbemycin oxime
The present invention provides a method for synthesizing Milbemycin oxime. The method comprises the following steps. (1) Oxidizing reaction: oxidizing...
US-9,598,428 Method for preparing a pyripyropene compound
The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a...
US-9,598,427 Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I): ##STR00001## wherein A.sub.1, A.sub.2, R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.3, R.sub.4, R.sub.5 and T are as defined in the...
US-9,598,426 Organic compounds
Provided are PDE1 inhibitors of Formula I, processes for their production and their use as pharmaceuticals, and pharmaceutical compositions comprising them.
US-9,598,425 Method for preparing Ibrutinib
Provided is a method for preparing Ibrutibin (I), and steps of preparing same comprise: 4-benzyloxybenzoyl chloride (II) is used as a raw material, condensation...
US-9,598,424 Heteroarylamide inhibitors of TBK1
The present invention provides compounds of formula 1: ##STR00001## which are useful as inhibitors of TBK-1, pharmaceutical compositionst thereof, methods for...
US-9,598,423 Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors
The invention provides compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein...
US-9,598,422 Immunoregulatory agents
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such...
US-9,598,421 Imidazopyridazine compounds
The present invention is directed to compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the substituents R.sup.1,...
US-9,598,420 Benzodiazepine bromodomain inhibitor
Benzodiazepine compounds of formula (I) ##STR00001## and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
US-9,598,419 Imidazotriazine and imidazodiazine compounds
The present invention provides thiazole compounds of Formula I ##STR00001## wherein X, Y, Z, X.sup.1, X.sup.2, X.sup.3, X.sup.4, X.sup.5, R.sup.1, R.sup.2,...
US-9,598,418 Substituted phthalazin-1 (2H)-one derivatives as selective inhibitors of poly (ADP-ribose) polymerase-1
The present invention relates to novel compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in...
US-9,598,417 (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the...
US-9,598,416 Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment cancer
This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-fJ[1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory...
US-9,598,415 Compounds as modulators of ROR.gamma.
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the variables are defined herein which are suitable for the modulation of...
US-9,598,414 Substituted benzo[5,6]azepino[3,2,1-hi]pyrido[4,3-b]indoles and substituted...
The present invention discloses pyridoinolobenz[b,e]azepine derivatives of Formula 1, ##STR00001## wherein X is --O--, --S--, --SO--, or --SO.sub.2--. Y is a...
US-9,598,413 Crystalline form of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-- ...
Crystalline form, Form T2H1.5-4, of N,Ndicyclopropyl-4-(1,5-dimethyl-1 Hpyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3- ...
US-9,598,412 Spiroindoline compounds for use as anthelminthics
This invention relates to spiroindoline compounds for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth...
US-9,598,411 Substituted benzimidazole-type piperidine compounds and uses thereof
The disclosure relates to Substituted Benzimidazole-Type Piperidine Compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts or solvates...
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