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Patent # Description
US-9,605,053 Influenza virus-neutralizing antibody and screening method therefor
Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according...
US-9,605,052 Method for extracting IgY (.gamma.-livetin) from egg yolk
A method for extracting IgY (.gamma.-livetin) from yolk is disclosed, which comprises the following steps: (A) providing a buffer solution, a yolk sample, and...
US-9,605,051 Viscosity-reducing excipient compounds for protein formulations
The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods...
US-9,605,050 Glycoprotein synthesis and remodeling by enzymatic transglycosylation
A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group...
US-9,605,049 Chimeric receptors with 4-1BB stimulatory signaling domain
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the...
US-9,605,048 Human soluble CD146, preparation and uses thereof
The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to...
US-9,605,047 Compositions and methods for treating hypertension
The technology described herein is directed to agents that reduce the level of oxidant-modified ET-B Cys405, Cys403, or Cys402 and the identification and use of...
US-9,605,046 Protease Activated Receptor-1 (PAR1) Derived Cytoprotective Polypeptides and Related Methods
The present invention provides novel PAR 1 derived cytoprotective oligopeptides or polypeptides which typically contain at least the first 4 N-terminal residues...
US-9,605,045 Expression of the human IGF-1 in transgenic plastids
A plastid transformation vector for stably transforming a plastid genome, comprising, as operably-linked components, a first flanking sequence, a DNA sequence...
US-9,605,044 Methods and compositions for modulating immune tolerance
The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for...
US-9,605,043 Fusion protein for suppressing cancer cell growth and suppressing vasculogenesis, and anticancer composition...
The present invention relates to a fusion protein resulting from the fusion of a cancer-specific antibody and an angiogenesis inhibitor, and relates to an...
US-9,605,042 Compositions and methods related to tauopathy
Disclosed herein are isolated polypeptides, antibody preparations, treatment methods, diagnostic methods, and screening methods related to tauopathy. Generally,...
US-9,605,041 Regulatory proteins and inhibitors
The invention provides a previously uncharacterized protein (gamma secretase activating protein or gSAP) that activates .gamma.-secretase to produce...
US-9,605,040 Nutritive proteins and methods
Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues...
US-9,605,039 Protein scaffolds for antibody mimics and other binding proteins
Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such...
US-9,605,038 Fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof for preventing and treating...
The present invention relates to a fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof. More specifically, the present invention relates...
US-9,605,037 Recombinant host cells and nucleic acid constructs encoding polypeptides having cellulolytic enhancing activity
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
US-9,605,036 Vaccines and diagnostics for the ehrlichioses
The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies,...
US-9,605,035 Vaccines and diagnostics for the ehrlichioses
The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies,...
US-9,605,034 Method and use for surface display of proteins and peptide derivatives in a bacterial thermophile
Provided are compositions are methods for discovery of new materials and interactions under extreme environmental conditions such as elevated temperatures at or...
US-9,605,033 Immunoreactive glycoprotein GP19 of ehrlichia canis
The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides,...
US-9,605,032 Immunoreactive glycoprotein GP19 Ehrlichia canis
The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides,...
US-9,605,031 In vitro reconstituted plant virus capsids for delivering RNA genes to mammalian cells
The invention provides compositions of matter comprising a cowpea chlorotic mottle virus capsid protein (CCMV CP) and a ribonucleic acid, as well as methods for...
US-9,605,030 Rapid selection method for HIV gp-120 variants
The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120...
US-9,605,029 Antibody-binding peptide
Polypeptides which have binding activity to an Fc region of immunoglobulin G and can be favorably used in detecting, purifying, immobilizing or removing an...
US-9,605,028 Antibacterial agents: salinamide derivatives
The invention provides compounds of formula (I): ##STR00001## and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit...
US-9,605,027 Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
The present invention relates to novel linear and cyclic polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor...
US-9,605,026 Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation
The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.
US-9,605,025 Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family
Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts...
US-9,605,024 PAR4 agonist peptides
Protease activated receptor 4 (PAR4) agonist peptides are disclosed. These peptides are useful for developing robust PAR4 receptor assays.
US-9,605,023 Application of SP peptide or derivative thereof in preparing medicines for preventing or treating asthma
The present invention provides an application of an SP peptide or a derivative thereof in preparing medicines for preventing or treating asthma. The peptide or...
US-9,605,022 Macrocyclic compounds for inhibition of inhibitors of apoptosis
There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of...
US-9,605,021 Indoline compounds as granzyme B inhibitors
Granzyme B inhibitor compounds, compositions that include the compounds, and methods for using the compounds. The compounds of the invention have advantageous...
US-9,605,020 Method for producing dipeptide derivative containing disubstituted amino acid residue
A method for producing a dipeptide that has a protected N-terminal and is represented by formula (1) or a salt of the dipeptide, said method comprising...
US-9,605,019 Methods for the synthesis of functionalized nucleic acids
The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising ...
US-9,605,018 Substituted nucleotide analogs
Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or...
US-9,605,017 2', 5'-dideoxy-5-fluorouridine derivatives having cytotoxic activity, a process for the manufacture thereof and...
The subject matter of the invention is novel 2',5'-dideoxy-5-fluorouridine derivatives of general formula 1. ##STR00001## wherein R.sub.1 denotes cinchona...
US-9,605,016 Method of esterification of carboxyl groups present on multihydroxyl cyclic polyene molecular structures...
Disclosed is a process for the preparation of partricin alkyl esters which involves reacting partricin in a solvent with primary alkyl alcohols in the quantity...
US-9,605,015 Polyene compound, method for preparing the same, and antifungal drug comprising novel polyene compound as...
The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel...
US-9,605,014 Glycomimetics to inhibit pathogen-host interactions
The present invention relates to novel glycomimetic compounds that are rationally designed to inhibit the binding of various pathogens to cell surface...
US-9,605,013 Derivatives of hemin with antibacterial and antiviral activity
The invention relates to hemin derivatives of general formula (I), preparing and use thereof as antibacterial and/or antiviral agents, including, as a component...
US-9,605,012 Palladium-ruthenium-zinc-organo complexes and methods for their use in the treatment of inflammatory diseases
The described invention provides organometallic complexes capable of spin transfer, comprising at least three different metals and the use of pharmaceutical...
US-9,605,011 Monophosphite compounds having an ether group
Novel monophosphite compounds having an ether group, and a process for preparing these compounds, which are especially suitable for use as ligands in...
US-9,605,010 Monophosphite compounds having a methyl group
Novel monophosphite compounds having a methyl group, and a process for preparing these compounds, which are especially suitable for use as ligands in...
US-9,605,009 Method for the purification of lecithin
A method for the purification of lecithin, comprising the steps of: a. reducing the viscosity of lecithin to a viscosity of less than about 10 Pas; then b....
US-9,605,008 Benzyl-1H-pyrazolo[3,4-b]pyridines and use thereof
The present application relates to novel benzyl-1H-pyrazolo[3,4-b]pyridines, to processes for their preparation, to their use alone or in combinations for the...
US-9,605,007 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,- 3-thiazol-4-yl amides
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have...
US-9,605,006 5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines
The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
US-9,605,005 Alkynyl alcohols and methods of use
The invention relates to compounds of Formula (0): ##STR00001## wherein Q, A.sup.1-A.sup.8, R.sup.4 and R.sup.5 and each has the meaning as described herein....
US-9,605,004 Chemical compounds
The invention relates to pyrrolone compounds of the formula (I), wherein X, R.sup.a, R.sup.b, R.sup.c, R.sup.1, R.sup.2 and R.sup.3 are as defined in the...
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