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Patent # Description
US-9,604,952 Compositions and methods for inhibiting cytochrome P450 2D6
Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or...
US-9,604,951 Process for making HMF from sugars with reduced byproduct formation, and improved stability HMF compositions
Disclosed is a process for making HMF or a derivative of HMF by dehydrating one or more hexose sugars in a reduced oxygen environment. In another, related...
US-9,604,950 Trail enhancers for the selective killing of cancer cells
The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor...
US-9,604,949 Prostaglandin conjugates and derivatives for treating glaucoma and ocular hypertension
Prostaglandin conjugates and derivatives and methods for their use to treat glaucoma and/or lower intraocular pressure are disclosed. Additionally, ophthalmic...
US-9,604,948 Process for preparing substituted 5-fluoro-1H-pyrazolopyridines
The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) ##STR00001##...
US-9,604,947 Substituted 5-imino-1,2,4-thiadiazoles that can be used to treat neurodegenerative diseases
The present invention is based on the use of a broad family of 5-imino-1,2,4-thiadiazoles as potential new drugs for the treatment of diseases in which PDE7...
US-9,604,946 Methods for modulating bacterial virulence and related compounds
The present invention relates to compounds and methods for the treatment of bacterial infections. The compounds and methods involve the disruption of the QseC...
US-9,604,945 Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders
Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression...
US-9,604,944 Arylpiperazine derivatives and methods of utilizing same
The present invention provides arylpiperazine derivatives having Formula 1a as shown below, which can be advantageously used for treating schizophrenia and...
US-9,604,943 UV absorber-containing urethane acrylate
The present invention relates to a UV absorber-comprising urethane acrylate, to a process for its preparation, and to the use thereof. The UV absorber is...
US-9,604,942 Preparation of haloalkoxyarylhydrazines and intermediates therefrom
The invention in this document is related to the field of preparation of haloalkoxyarylhydrazines and certain intermediates derived therefrom, where said...
US-9,604,941 Preparation method of conjugated compound containing bis(phenylsulfonyl)benzene structure and an organic...
The invention provides a conjugated compound containing a bis(phenylsulfonyl)benzene structure, a preparation method and an application thereof, the compound...
US-9,604,940 2-aminopyrazine derivatives as CSF-1R kinase inhibitors
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, N-oxide, hydrate or solvate thereof: wherein: ring A, R.sup.1,...
US-9,604,939 Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-YL)pyridin-3-YL)-1-((trans)-4-methoxycyclohexyl)-- ...
Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid...
US-9,604,938 Amino quinazolines as kinase inhibitors
Disclosed are compounds having the formula (Formula I)): wherein R.sup.1, R.sup.2, R.sup.3 and Z are as defined herein, and methods of making and using the...
US-9,604,937 Pyrimidine-2,4-diamine derivatives for treatment of cancer
A compound of formula (I), or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit...
US-9,604,936 Besylate salt of a BTK inhibitor
The present invention provides a salt form, and compositions thereof, useful as an inhibitor of one or more protein kinases and which exhibits desirable...
US-9,604,935 Deuterated phenyl amino pyrimidine compound and pharmaceutical composition containing the same
The present invention relates to a deuterated phenyl amino pyrimidine compound and pharmaceutical composition containing the same. Specifically provided are a...
US-9,604,934 Urea hydantoin derivatives as formyl peptide modulators
The present invention relates to urea hydantoin compounds, processes for preparing them, pharmaceutical compositions containing them, and their use as...
US-9,604,933 Pyrazolochalcones as potential anticancer agents
The present invention relates to a pyrazolochalcone of formula A useful as potential antitumor agent against human cancer cell lines and a process for the...
US-9,604,932 Substituted 1-pyrrolidinyloxy, 1-piperidinyloxy and 1-azepanyloxy compounds for treating diseases associated...
Compounds are of the class of 1-pyrrolidinyloxy,1-piperidinyloxy, and 1-azepanyloxy derivatives of formula (I): ##STR00001## The compounds are useful in...
US-9,604,931 Nuclear receptor binding agents
The present application relates to methods of treating, preventing, delaying the onset of, reducing the incidence of, or reducing the severity of hypertension...
US-9,604,930 Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,604,929 Functionalized carbon nanoparticles and functional polymer fibers prepared using the same
The present invention relates to a functionalized carbon nanoparticle prepared by modifying the surface of a carbon nanoparticle with C.sub.5-10 aryl or...
US-9,604,928 Light-emitting element
A light-emitting element having high external quantum efficiency is provided. A light-emitting element having a long lifetime is provided. A light-emitting...
US-9,604,927 Indolinone compounds and uses thereof
Indolinone derivative compounds that act as EWS-FLI1 transcription factor inhibitors are provided. Also provided are pharmaceutical compositions of the...
US-9,604,926 Highly selective sigma receptor radioligands
Compounds having the general formula III', or IV' ##STR00001## wherein R.sub.1 can be a radical of an optionally substituted C-4 to C-7 N-containing...
US-9,604,925 Class II HMG-CoA reductase inhibitors and methods of use
Disclosed are compositions and methods for treating bacterial infections.
US-9,604,924 Substituted biaryl sulfonamides and the use thereof
Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of...
US-9,604,923 Small molecule inhibitors of STAT3 with anti-tumor activity
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3...
US-9,604,922 Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
The present invention provides compounds and pharmaceutical compositions for treating neurological diseases such as multiple sclerosis.
US-9,604,921 Sulfonium salt, resist composition and resist pattern forming process
A sulfonium salt of formula (0-1) is provided wherein W is alkylene or arylene, R.sup.01 is a monovalent hydrocarbon group, m is 0, 1 or 2, k is an integer:...
US-9,604,920 Compositions and methods for the treatment of hyperglycemia and metabolic syndrome
The invention relates to the compounds and compositions of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI or its pharmaceutical...
US-9,604,919 Disubstituted amino acids and methods of preparation and use thereof
Provided are crystalline .alpha., .alpha.-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as...
US-9,604,918 Carboxylic acid ester/carbamate compound with polymerizable functional group and fluorine atom group, and...
Provided are a fluorine-containing monomer soluble in a hydrocarbon-based solvent as well as excellent in water and oil repellence, and a manufacturing method...
US-9,604,917 Treatment of sleep-wake disorders
This invention is directed to a method of treating Excessive daytime Sleepiness (EDS) in a subject, comprising the step of administering a therapeutically...
US-9,604,916 Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator...
This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention...
US-9,604,915 Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is --CN...
US-9,604,914 Process for preparing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester
This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of...
US-9,604,913 Crystalline diacylhydrazine and the use thereof
The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid ...
US-9,604,912 Compositions and methods for the treatment of hyperglycemia and metabolic syndrome
The compositions and compounds of Formula I, Formula II, Formula III which includes a salts of polyunsaturated fatty acids in a molecular conjugate form with an...
US-9,604,911 Process for the synthesis of agomelatine
Process for the industrial synthesis of the compound of formula (I): ##STR00001##
US-9,604,910 Composition of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet...
Disclosed are 5-nitrobenzoate derivatives of Formula I, ##STR00001## and the preparation method therefor, wherein R is referred to hydrogen (H), unsubstituted,...
US-9,604,909 L-ornithine phenyl acetate and methods of making thereof
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V,...
US-9,604,908 Diether based biodegradable cationic lipids for siRNA delivery
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid...
US-9,604,907 Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics
Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount...
US-9,604,906 Process for the preparation of 3-aryloxy-3-phenylpropylamine and salt thereof
The present invention relates to an industrially feasible and economically viable process for the preparation of 3-aryloxy-3-phenylpropylamine and salt of...
US-9,604,905 Isomerization method for bis (aminomethyl) cyclohexane
A method for isomerizing a bis(aminomethyl)cyclohexane, including an isomerization step of isomerizing the bis(aminomethyl)cyclohexane in the presence of an...
US-9,604,904 Alpha- and gamma-truxillic acid derivatives and pharmaceutical compositions thereof
The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a...
US-9,604,903 Metathesis process
A process of metathesizing a feedstock in the presence of a metathesis catalyst and at least one catalyst enhancer. The catalyst enhancer can be selected from a...
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