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Patent # Description
US-9,611,309 Methods of use of soluble CD24 for therapy of rheumatoid arthritis
Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian...
US-9,611,308 Compositions and methods for enhancing odorant receptor activity
The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides...
US-9,611,307 Method for increasing granulocyte number in a patient by administering superactive IL-33 fragments
The present invention discloses novel active polypeptide fragments of human IL-33 corresponding to natural forms generated by the proteases of human neutrophils...
US-9,611,306 TGFB type II-type III receptor fusions
Certain embodiments are directed to novel heterotrimeric fusions in which the ectodomain of the TGF-.beta. type II receptor (T.beta.P?II) is coupled to the N-...
US-9,611,305 Treating cardiovascular or renal diseases
This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic...
US-9,611,304 TNNT1 mini-promoters
Isolated polynucleotides comprising a TNNT1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter...
US-9,611,303 Modified biotin-binding protein
The present invention provides a modified biotin-binding protein comprising an amino acid sequence represented by SEQ ID NO: 2 or its modified sequence and...
US-9,611,302 High-transduction-efficiency RAAV vectors, compositions, and methods of use
The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or...
US-9,611,301 GB virus C (hepatitis G virus) E2 glycoprotein as an immunomodulatory agent
GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods...
US-9,611,300 cDNA construct of Salmonidae alphavirus
The invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a...
US-9,611,299 Method for highly expressing recombinant protein of engineering bacteria and use thereof
Provided are methods for highly expressing recombinant protein of engineering bacteria and the use thereof. The method comprises the following steps: (1)...
US-9,611,298 Charged nutritive proteins and methods
Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the...
US-9,611,297 Compositions and methods for the treatment of cast nephropathy and related conditions
Provided are novel peptides of Formula SEQ ID No. 1: J.sup.1CysX.sup.1X.sup.2X.sup.3X.sup.4X.sup.5X.sup.6ProX.sup.7ThrCysJ.sup- ...
US-9,611,296 Peptides that bind to amino-truncated amyloid-beta-peptide and use of said peptides
Peptides that bind to amino-terminal truncated pEA.beta.3-42, the free glutamic acid residue of which lies in position 3 or 11 in the form of cyclized...
US-9,611,295 Treatment of IL-17 mediated disease by blocking SEFIR-SEFIR interactions
A method of treating an IL-17 mediated disease in a subject by administering to the subject a therapeutically effective amount of a of a cell-permeable decoy...
US-9,611,294 Peptides mimicking HIV-1 viral epitopes in the V2 loop for the GP120 surface envelope glycoprotein
The present invention relates to an isolated immunogenic peptide comprising a V2 loop fragment from HIV surface envelope glycoprotein gp120. This peptide binds...
US-9,611,293 Synthesis of beta-arrestin effectors
Embodiments disclosed herein provide compounds and methods for preparing Beta-Arrestin Effectors.
US-9,611,292 Peptide inhibitors of serotonin 5-HT2c receptors:PTEN interaction
The 5-HT 2C receptor is implicated in feeding, obesity, palatable food reward, metabolic disorders, drug addiction, anxiety, stress sensitivity, and depression....
US-9,611,291 Use of a tetraphenylborate (TPB) salt for the separation of biomolecules
Process for the separation of a biomolecule containing at least one cationic group from a liquid medium containing said biomolecule, which comprises the use of...
US-9,611,290 Trypsin-like serine protease inhibitors, and their preparation and use
The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss...
US-9,611,289 Farnesoid X receptor modulators
The present invention provides a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein...
US-9,611,288 Compounds and methods involving sterols
Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The...
US-9,611,287 Trioxacarcins and uses thereof
The present invention relates to trioxacarcin compounds of the formula: ##STR00001## or pharmaceutically acceptable forms thereof; wherein R.sup.1, R.sup.2,...
US-9,611,286 Ruthenium carbon monoxide releasing molecules and uses thereof
The present invention provides novel ruthenium compounds of Formula (I): ##STR00001## or salts, isomers, hydrates, or solvates thereof, or combinations...
US-9,611,285 Fucosyltransferases and their applications
The present invention relates to nucleic acid and amino acid sequences from Escherichia coli serogroup O126, coding for/representing a novel ...
US-9,611,284 Prostaglandin-bisphosphonate conjugate compounds, methods of making same, and uses thereof
The invention provides in part, conjugate compounds. The invention also provides synthesis methods for making the compounds, and uses of the compounds.
US-9,611,283 Methods for inhibiting cell proliferation in ALK-driven cancers
The invention features a method for treating patients who have an ALK-driven cancer, which is, or has become, refractory to one or more of crizotinib, CH5424802...
US-9,611,282 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as ...
4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using the...
US-9,611,281 BODIPY derivatives and methods of synthesis and use thereof
Derivatives of BODIPY (boron dipyrromethene difluoride) and their synthesis and use are disclosed.
US-9,611,280 Tetraaryl borate compound and method for producing same
The present invention relates to a novel tetraaryl borate compound and a method for producing the same, and a method for producing a tetraaryl borate compound...
US-9,611,279 Zinc complex
A zinc complex characterized in exhibiting an octahedral structure and being configured from repeating units represented by general formula (I): ##STR00001## ...
US-9,611,278 Soluble guanylate cyclase activators
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate...
US-9,611,277 Substituted 2-azabicycles and their use as orexin receptor modulators
The present invention is directed to compounds of Formula I: wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl,...
US-9,611,276 Imidazo bicyclic iminium compounds as antitumor agents
Compounds of formula I: ##STR00001## are disclosed. The compounds are inhibitors of Hedgehog pathway activation and are useful in treating solid tumors. An...
US-9,611,275 Permeable glycosidase inhibitors and uses thereof
The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase...
US-9,611,274 Macrocycles as factor XIa inhibitors
The present invention provides compounds of Formula (Ia): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein...
US-9,611,273 Trioxane thioacetal monomers and dimers and methods of use thereof
Monomeric and dimeric trioxane thioacetals and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases...
US-9,611,272 Polymorphic forms of icotinib and uses thereof
The present invention relates to the polymorphic forms of the compound of Formula I, preparation thereof and pharmaceutical compositions, and use of a polymorph...
US-9,611,271 C20' urea derivatives of vinca alkaloids
A vinca alkaloid compound that is substituted at the 20'-position with a urea or thiourea group is disclosed. The urea's proximal nitrogen atom bonded to the...
US-9,611,270 Inhibitors of CYP17A1
Compounds according to formula I or II are provided. Such compounds are useful in treating cancers, such as leukemia, colon cancer, breast cancer, or prostate...
US-9,611,269 Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
The present invention provides azetidinyl phenyl, pyridyl, or pyrazinyl carboxamide derivatives, as well as their compositions and methods of use, that modulate...
US-9,611,268 Modulators of toll-like receptor 7
The present application includes a compound of Formula I or II: ##STR00001## or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions...
US-9,611,267 Substituted tricyclic compounds as FGFR inhibitors
The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are...
US-9,611,266 Compounds and anti-tumor NQO1 substrates
Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment,...
US-9,611,265 Tropomyosin-related kinase (TRK) inhibitors
Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as...
US-9,611,264 N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-y- l)-1,3-thiazol-4-yl] amides
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have...
US-9,611,263 Compounds that modulate intracellular calcium
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels....
US-9,611,262 Substituted 2-azabicycles and their use as orexin receptor modulators
The present invention is directed to compounds of Formula I: ##STR00001## Methods of making the compounds of Formula I are also described. The invention also...
US-9,611,261 Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula...
US-9,611,260 Compositions and methods for inhibition of the JAK pathway
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in...
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