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Patent # Description
US-9,611,259 Substituted pyridine derivatives useful as C-FMS kinase inhibitors
The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives...
US-9,611,258 Dual MEK/PI3K inhibitors and therapeutic methods using the same
Dual inhibitors of MEK and PI3K and compositions containing the same are disclosed. Methods of using the dual MEK/PI3K inhibitors in the treatment of diseases...
US-9,611,257 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,611,256 Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers
A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az...
US-9,611,255 Process for total synthesis of flavonoid compounds and isomers thereof
The present invention relates to the a process for total synthesis of flavonoid compounds of general formula I and isomers thereof ##STR00001## wherein R.sub.1...
US-9,611,254 Triazole compounds and their use as gamma secretase modulators
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical...
US-9,611,253 Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith
Solid forms comprising pyrazolylaminoquinazoline, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the...
US-9,611,252 Therapeutic inhibitory compounds
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma...
US-9,611,251 Substituted piperidine compounds and their use as orexin receptor modulators
The present invention is directed to compounds of Formula I: wherein X is CR.sub.1 or N; Y is CR.sub.2 or N; Z is NH or O; R.sub.1 is alkoxy, triazolyl,...
US-9,611,250 Process for preparing 4-(cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridyl)-5-methoxypyridi- ...
The present invention relates to a novel process for preparing the compound 4-(cyclopropylmethoxy)-N-(3,5-di-chloro-1-oxido-4-pyridyl)-5-met- ...
US-9,611,249 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
The present invention relates to the 1H-indazole-3-carboxamide compounds having the following general formula (I) as glycogen synthase kinase 3 beta...
US-9,611,248 Chemical compounds
The invention relates to pyrrolone compounds of the formula (I) ##STR00001## wherein X, R.sup.1, R.sup.2, R.sup.3 and A are as defined in the specification....
US-9,611,247 Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with acrylonitrile to provide ...
US-9,611,246 Compositions, apparatus, systems, and methods for resolving electronic excited states
The present disclosure relates, according to some embodiments, to molecules, including conjugated fused polycyclic molecules, that may receive excited state...
US-9,611,245 Diarylalkylamine REV-ERB antagonists and their use as medicaments
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical...
US-9,611,244 Cyclic compounds
The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of...
US-9,611,243 Method of producing beraprost
An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d...
US-9,611,242 Process for preparation of dronedarone by N-butylation
The invention relates to a compound of formula (II) ##STR00001## and salts thereof. Also described herein are processes for the preparation of a compound of...
US-9,611,241 Conversion of fructose-containing feedstocks to HMF-containing product
The present invention relates generally to processes for converting fructose-containing feedstocks to a product comprising 5-(hydroxymethyl)furfural (HMF) and...
US-9,611,240 14-hydroxy-docosahexaenoic acid compounds
The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
US-9,611,239 14-hydroxy-docosahexaenoic acid compounds
The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.
US-9,611,238 14-hydroxy-docosahexaenoic acid compounds
The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.
US-9,611,237 Phosphor materials and related devices
A phosphor material is presented that includes a blend of a first phosphor, a second phosphor and a third phosphor. The first phosphor includes a composition...
US-9,611,236 Method for producing ethylene oxide
[Problem] To provide a method by which an amount of production of ethylene glycol as a by-product is reduced and a yield of ethylene oxide can be improved in a...
US-9,611,235 Methods and compositions related to a retinoid receptor-selective pathway
Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a...
US-9,611,234 Choline cocrystal of epalrestat
The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidinea- cetic acid. The preparation and...
US-9,611,233 Organic compound
The present invention provides an organic compound to be used in an electrochromic device. The organic compound has excellent oxidation-reduction repeating...
US-9,611,232 Oxazolidinone and imidazolidinone compounds
The invention provides compounds having the general formula I ##STR00001## wherein n, R.sup.1, R.sup.2a, R.sup.2b, R.sup.3a and R.sup.3b are as herein defined,...
US-9,611,231 Method for preparing 3-trifluoromethyl chalcones
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture...
US-9,611,230 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by...
US-9,611,229 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the...
US-9,611,228 Stabilized compositions and methods of manufacture
A method for stabilization of potent alkanone-heterocyclic flavorants in dry powder form is provided. Coordination of alkanone-heterocyclic flavorants to...
US-9,611,227 Antitumor effect potentiator and antitumor agent
The present invention provides an antitumor effect potentiator for enhancing antitumor activity of an antitumor agent comprising tegafur in a therapeutically...
US-9,611,226 Preparation method for azoxystrobin
Disclosed in the present invention is a preparation method of azoxystrobin having a structure as shown by formula (1), the method comprising: a) performing an...
US-9,611,225 Process for preparation of androgen receptor antagonist
The present invention provides an isopropanol solvate of enzalutamide. The present invention also provides a process for the preparation of androgen receptor...
US-9,611,224 Antiproliferative benzo [B] azepin-2-ones
Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are described in...
US-9,611,223 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
US-9,611,222 Pyridine compounds and the uses thereof
The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein...
US-9,611,221 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or...
US-9,611,220 Inhibitors of histone demethylases
The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment...
US-9,611,219 Inhibitors of histone demethylases
The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment...
US-9,611,218 Metal-organic materials and method for preparation
The present invention provides metal-organic materials, more specifically organometallic polymers, comprising polypyridyl organic ligands such as ...
US-9,611,217 Synthetic processes of carprofen
Methods and intermediates for the synthesis of carprofen and its derivatives starting from cyclohexanone are disclosed.
US-9,611,216 Compound with branching alkyl chains, method for preparing the same, and use thereof in photoelectric device
The invention discloses a compound having branching alkyl chains, the method for preparing the same and use thereof in photoelectric devices. By applying the...
US-9,611,215 Nucleophile-reactive sulfonated compounds for the (radio)labelling of (bio) molecules; precursors and...
Nucleophile-reactive sulfonated compounds used as precursors to (radio)labelled (bio)molecules are produced by pre-introduction of a nucleophilic compound R*...
US-9,611,214 N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
The present invention provides a pyrrolidine compound of General Formula (1) ##STR00001## or a salt thereof, wherein R.sup.101 and R.sup.102 are each...
US-9,611,213 Functionalized 1,3-benzene diols and their method of use for the treatment of hepatic encephalopathy
Pharmaceutical compositions of the invention include novel functionalized 1,3-benzenediols having a disease-modifying action in the treatment of hepatic...
US-9,611,212 Polyol estolides and methods of making and using the same
Provided herein are polyol estolide compounds. Polyol estolides may be prepared by contacting a polyol with an estolide compound. Also provided are compositions...
US-9,611,211 1-(2-acyloxyethyl)cyclopropyl sulfonate compound, 3-halomethyl-3-butenyl carboxylate compound, and method for...
Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More...
US-9,611,210 Single-pot synthesis of dialkyl carbonates using catalyst from natural resource
The present invention relates to a single-pot method for preparing dialkyl carbonates, the method comprises reaction of alkylene oxide with aliphatic or cyclic...
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