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Patent # Description
US-9,642,862 Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and...
The invention relates to a method of reducing chronic inflammatory pain in a human subject with androgen deficiency symptoms comprising transdermally...
US-9,642,857 Substituted (E)-N'-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
Methods of treatment of disorders of uncontrolled cellular proliferation, including cancer, by administering substituted ...
US-9,642,856 Treatment for pancreatic cancer
The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a...
US-9,642,855 Substituted pyrrolo[2,3-d]pyrimidines as LRRK2 inhibitors
The present invention provides novel 4,5-disubstituted-7H-pyrrolo[2,3-d]pyrimidine derivatives of Formula I, and the pharmaceutically acceptable salts thereof ...
US-9,642,854 Flavanoid compounds and process for preparation thereof
The present invention relates to flavanoid compounds of general formula (X.sub.1) wherein: R.sub.1 is selected from a group consisting of morpholinyl, N-methyl...
US-9,642,853 Stable pharmaceutical composition containing folates
The administration of leucovorin as well as other active, reduced folates is useful as an antidote to drugs which act as folic acid antagonists and in...
US-9,642,852 Sulfur-containing bicyclic compound
A sulfur-containing bicyclic compound of the present invention has a PAM action of GABA.sub.B. A composition containing the sulfur-containing bicyclic compound....
US-9,642,851 Indolinone derivative as tyrosine kinase inhibitor
The present invention relates to a compound represented by general formula (I), a method for preparing said compound, a pharmaceutical formulation containing...
US-9,642,850 Method of providing sustained analgesia with buprenorphine
A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day...
US-9,642,849 Nalmefene for reduction of alcohol consumption in specific target populations
The present invention relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who has a high drinking risk...
US-9,642,848 Sublingual naloxone spray
The invention provides storage stable sublingual formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention...
US-9,642,847 Combinational compositions and methods for treatment of cancer
The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a...
US-9,642,846 Antifungal drugs
The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need...
US-9,642,845 Method for alleviating side effects of retinoic acid therapy and/or improving efficacy without interfering with...
The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy....
US-9,642,844 Sublingual fentanyl spray
The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable sale thereof, or derivative thereof, suitable...
US-9,642,843 Pharmaceutical compounds and use of same in cancer and tauopathies
Disclosed are compounds of formula (1)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating...
US-9,642,842 Opioid receptor ligands and methods of using and making same
This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain...
US-9,642,841 Snoring treatment
The present invention features compositions and methods for treatment of snoring. We describe compositions comprising an antihistamine or a pharmaceutically...
US-9,642,840 Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
Disclosed herein are methods of treating conditions, which may be associated with elevated levels of plasma cells and/or B-cells, with a therapeutically...
US-9,642,839 Substance having tyrosine kinase inhibitory activity and preparation method and use thereof
Disclosed in the present disclosure are substances having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substances...
US-9,642,838 Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin...
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form...
US-9,642,837 Methods of treating Alzheimer's disease and pharmaceutical compositions thereof
The present invention describes methods of treating dementia comprising administering an effective daily dose of ...
US-9,642,836 Isotopologues of isoindole derivatives
Provided herein are isoindole derivatives, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched...
US-9,642,835 Modulators of GTPase and use in relevant treatment
The present invention relates to molecules which function as selective modulators (i.e., inhibitors and agonists, preferably inhibitors) of the Ras-homologous...
US-9,642,834 Composition comprising alpha-lipoic acid and honokiol for treating neuropathies
The present invention relates to a composition comprising alfa-lipoic acid, or a salt or complex thereof, and honokiol, wherein the weight quantity of said...
US-9,642,833 Vitamin C and vitamin K, and compositions thereof for treatment of osteolysis or prolongation of prosthetic implant
Provided herein is a method of treating, preventing, or managing osteolysis in a subject, comprising administering to the subject a therapeutically effective...
US-9,642,832 Use of atractylenolide compound or its derivatives and a medicament for inhibiting platelet aggregation
A medicament for inhibiting platelet aggregation, comprising atractylenolide compound or its derivatives, wherein the said atractylenolide compound has the...
US-9,642,831 Substituted chromanes and method of use
The invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, X, Y, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10,...
US-9,642,830 Use of sting agonists to treat hepatitis B virus infection
The invention includes methods of treating a subject having hepatitis B viral (HBV) infection. In certain embodiments, the method of the invention comprises...
US-9,642,829 Antifungal compound and uses thereof
Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small...
US-9,642,828 Parenteral dosage form of amiodarone
The present invention relates to a stable, sterile, ready to administer parenteral dosage form of amiodarone or its pharmaceutically acceptable salt....
US-9,642,827 Method for treating skin cancer
A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the...
US-9,642,826 Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
An emulsion is provided including: an oil component and a water component, the oil component including: fish oil triglycerides in an amount of about 60% to...
US-9,642,825 Bio-available N-acetyl creatine species and compositions thereof
Creatine derivatives and compositions containing a bioactive form of creatine. The new chemical entity comprises an acetyl creatine, N-acyl creatines,...
US-9,642,824 Valaciclovir and diclofenac combination therapy for functional somatic syndromes
The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound...
US-9,642,823 Methods of treating tinnitus
The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods...
US-9,642,822 Methods for treating and preventing neutrophil-derived net toxicity and thrombosis
Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus...
US-9,642,821 MiR-182 in the diagnosis and treatment of cancer
The present disclosure provides methods of determining the levels of BRCA1 in a cell, altering the levels of BRCA1 in a cell, determining the likelihood of...
US-9,642,820 Materials and methods for controlling infections
The subject invention provides materials methods for reducing infections in subjects. The materials methods utilize chlorhexidine, which has been found to be...
US-9,642,819 Low dosage serotonin 5-HT2A receptor agonist to suppress inflammation
The present invention is directed to a method for the treatment of an inflammatory disorder in a mammal, said method comprising administering to a mammal in...
US-9,642,818 Compositions and methods for nutrition supplementation
The present invention relates to compositions that may be swallowable, chewable or dissolvable, comprising various vitamins and minerals, and in a specific...
US-9,642,817 Liposomal compositions and uses of same
Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical...
US-9,642,816 Nanocapsules of protamine
The present invention relates to the design and development of nanocapsule systems for the administration of active substances, wherein the nanocapsules of the...
US-9,642,815 Biocompatible graphene quantum dots for drug delivery and bioimaging applications
In this work we have targeted two aspects of GQDs, Size and ROS to reduce their cytotoxicity. Small size can damage cell organelles and production of ROS...
US-9,642,814 Microencapsulation technique and products thereof
Inside-out gelation process to generate hydrogel microcapsules (aka microbeads). Methods of encapsulating biological material in the microbead 3-dimensional...
US-9,642,813 Method for producing soft capsule type external preparation, softening liquid, and soft capsule type external...
The invention is to provide a method for producing a soft capsule type external preparation (and a softening liquid (L) used for the production thereof, and an...
US-9,642,812 Dosator apparatus for filling a capsule with dry powder
The invention relates to a dosator which comprises a tapered elongate cavity; a stationary plunger disposed within the cavity; a removable mesh screen disposed...
US-9,642,811 Abuse deterrent immediate release biphasic matrix solid dosage form
An abuse deterrent immediate release biphasic matrix solid dosage form that releases the drug at a desired rate for quick onset of action when a single unit or...
US-9,642,810 Formulation containing carbidopa, levodopa, and entacapone
Disclosed herein are stable pharmaceutical dosage forms containing carbidopa, levodopa, and entacapone. The dosage forms are prepared by mixing carbidopa,...
US-9,642,809 Controlled release pharmaceutical compositions for prolonged effect
Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part of the gastrointestinal...
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