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Patent # Description
US-9,644,047 Metallocenes and catalyst compositions derived therefrom
This invention relates to a novel group 2, 3 or 4 transition metal metallocene catalyst compound having two indenyl ligands with identical substitution...
US-9,644,046 Method for producing modified conjugated diene-based polymer, modified conjugated diene-based polymer, and...
A method for producing a modified conjugated diene-based polymer having a good balance between the hysteresis loss properties and the wet skid resistance,...
US-9,644,045 End-functionalized conjugated diene-based polymer and process for producing same
Disclosed are a modified conjugated diene-based polymer represented by Chemical Formula 1, a method of preparing the same, and a rubber composition including...
US-9,644,044 Process and catalyst for resin hydrogenation
The invention is in the field of catalysis. More specifically, the invention pertains to catalytic hydrogenation processes and catalysts used therein. According...
US-9,644,043 Method for producing hydrogenated petroleum resin
A manufacturing method of a hydrogenated petroleum resin of the invention includes: a thermal polymerization step of thermally polymerizing a cyclopentadiene...
US-9,644,042 Electrochemically mediated atom transfer radical polymerization
Electrochemical reduction of an exemplary ATRP catalyst, C.sup.IIBr.sub.2/Me.sub.6TREN, is shown to be an efficient process to mediate and execute an ATRP. The...
US-9,644,041 Process and apparatus for production of halogenated butyl rubber with reduced emissions
The present invention relates to a process for the production of halogenated butyl rubber and an apparatus for the production of rubber cement for use in the...
US-9,644,040 Hyaluronic acid derivatives
The present disclosure relates to hyaluronic acid derivatives, and in particular, derivatives in which the N-acetyl group of hyaluronic acid has been...
US-9,644,039 Acid-degradable and bioerodible modified polyhydroxylated materials
Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby...
US-9,644,038 Apolipoprotein nanodiscs with telodendrimer
The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The...
US-9,644,037 Antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at...
Monoclonal antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 (pT1989 ATR), antigen binding...
US-9,644,036 Predictive marker for topoisomerase I inhibitors
The present invention generally relates to phospho-serine 10 topoisomerase I antibodies and other protein binding moieties, and kits and uses thereof.
US-9,644,035 Methods for treating conditions associated with MASP-2 dependent complement activation
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the...
US-9,644,034 Anti-RSPO2 antibodies and uses thereof
The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides...
US-9,644,033 Protein constructs designed for targeting and lysis of cells
The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic...
US-9,644,032 Antibodies against OX40 and uses thereof
Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications,...
US-9,644,031 Epidermal growth factor receptor antibody
Provided are an improved EGFR antibody or a functional segment thereof, comprising an engineered heavy chain and light chain. Specifically, the antibody is an...
US-9,644,030 Antibodies to VLA-1
Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are...
US-9,644,029 Cancer diagnosis and treatment of cancer using anti-ROBO1 antibody
A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth...
US-9,644,028 Anti-CDH3 humanized antibody, drug conjugate thereof, and use thereof
The present invention provides an anti-CDH3 humanized antibody having lower immunogenicity, and an anti-CDH3 humanized antibody drug conjugate having the...
US-9,644,027 Antibodies that specifically bind to DRG11-responsive (DRAGON) proteins
This invention features antibodies that specifically bind to a murine Dragon family protein.
US-9,644,026 Antibody against mutant .alpha.-actinin-4
An antibody against mutant .alpha.-actinin-4 having an amino acid sequence with at least one amino acid residue substitution in the region between position 245...
US-9,644,025 Immunotherapy regimes dependent on ApoE status
The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype...
US-9,644,024 Nucleotide sequences, vectors and host cells
Polynucleotides encoding fusion proteins comprising fragments of toxin A and toxin B from Clostridium difficile are described, as well as vectors and host cells...
US-9,644,023 Compositions and methods for phagocyte delivery of anti-staphylococcal agents
The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding...
US-9,644,022 Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the...
Amino acid sequences are provided that are directed against/and or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in...
US-9,644,021 Bovine fusion antibodies
Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or...
US-9,644,020 Human Tim-3 fusion protein capable of blocking Tim-3 signaling pathway
The present invention provides a human Tim-3-Ig fusion protein which can block Tim-3 signal pathway, and said Ig fusion protein comprises Tim-3 protein, human...
US-9,644,019 Compounds for treating cardiac damage after ischaemia/reperfusion
The present invention relates to the use of an Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) inhibitor for preventing and/or treating cardiac damage...
US-9,644,018 Antibody modulators of APLNR
The present invention provides apelin receptor (APLNR) modulators that bind to APLNR and methods of using the same. The invention includes APLNR modulators such...
US-9,644,017 Insulin derivatives having an extremely delayed time-action profile
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end...
US-9,644,016 Soluble notch receptor proproteins and methods of use thereof
The present disclosure provides for proprotein and activatable proprotein compositions. A proprotein contains a functional protein (i.e. a full length protein...
US-9,644,015 Codon optimized sequence for an antiviral protein
A codon optimized nucleic acid sequence for Interferon Alpha-2a is provided which can be used for expression of Interferon Alpha-2a in E. Coli.
US-9,644,014 Modified animal erythropoietin polypeptides and their uses
Modified animal erythropoietin polypeptides and uses thereof are provided.
US-9,644,013 Partial region polypeptide of REIC/Dkk-3 protein
A polypeptide capable of strongly inducing and activating dendritic-cell-like cells for treating or prevent cancer by immunotherapy, and DNA encoding the...
US-9,644,012 Production of proteins and polypeptides
A method of producing a desired non-spidroin protein or polypeptide is comprising the steps of expressing in a suitable host a fusion protein, obtaining a...
US-9,644,011 Mu-conotoxin peptides and use thereof as a local anesthetic
The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. The invention...
US-9,644,010 LY6K epitope peptides for TH1 cells and vaccines containing the same
Isolated LY6K-derived epitope peptides having Th1 cell inducibility are disclosed herein. Such peptides can be recognized by MHC class II molecules and induce...
US-9,644,009 L-amino acid-producing bacterium and a method for producing an L-amino acid
An L-amino acid is produced by culturing a microorganism of the family Enterobacteriaceae which has the ability to produce an L-amino acid and which has been...
US-9,644,008 Deglycosylated hemagglutinin and manufacture thereof
The invention provides a deglycosylated hemagglutinin, wherein the glycosylation site(s) on the stem region is removed. The deglycosylated hemagglutinin may...
US-9,644,007 Red genetically encoded calcium indicators and methods of use
Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (GECIs) disclosed herein rival best-of-class green...
US-9,644,006 Carrier peptides for cell delivery
The invention relates to the technological sector of the transport and delivery of molecules into cells, either at cytoplasm or at nucleus or inter-cells (cell...
US-9,644,005 Didemnin biosynthetic gene cluster in Tistrella mobilis
A novel Tistrella mobilis strain having Accession Deposit Number NRRL B-50531 is provided. A method of producing a didemnin precursor, didemnin or didemnin...
US-9,644,004 Peptide and peptidomimetic inhibitors
The present invention provides inhibitors and/or antagonists of plasma kallikrein. Also provided are methods of utilizing the inhibitors as therapeutics.
US-9,644,003 RTN4B polypeptide, monoclonal antibody thereof, monoclonal antibody-producing hybridoma cell strain, and,...
The present invention relates to a RTN4B-related polypeptide, a monoclonal antibody thereof, a monoclonal antibody-producing hybridoma cell strain, and,...
US-9,644,002 Allosteric modulators of EGFR and constitutively active mutants
The present invention includes a novel class of allosteric modulators that target a protein having a juxtamembrane segment. In another embodiment, the...
US-9,644,001 Cell-penetrating peptides
A vector that includes a cell-penetrating peptide linked to a therapeutic agent. The therapeutic agent can be a cytotoxic agent, an anti-viral agent, an...
US-9,644,000 V1a receptor agonists
Compounds of formula (I), salts thereof, and compositions and uses thereof are described. The compounds are useful as V1a vasopressin agonists, for the...
US-9,643,999 Hepatitis C virus inhibitors
Hepatitis C virus inhibitors having the general formula (I) ##STR00001## are disclosed. Compositions comprising the compounds and methods for using the...
US-9,643,998 Real time monitoring and control of protein production processes using impedance spectroscopy
Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance...
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