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Patent # Description
US-9,643,997 Capture purification processes for proteins expressed in a non-mammalian system
Methods of purifying proteins expressed in non-mammalian expression systems in a non-native soluble form directly from cell lysate are disclosed. Methods of...
US-9,643,996 Processes for producing protein microparticles
Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized...
US-9,643,995 Triterpene glycoside and triterpene compositions and methods of using same
In the present invention, different strategies are used to improve the bioavailability of triterpene glycosides and triterpenes including, for example, (a) a...
US-9,643,994 Crystalline polymorphic form of ulipristal acetate
A novel crystalline polymorphic form of ulipristal acetate useful as an agent for preventing and/or treating uterine leiomyoma and as a contraceptive, and a...
US-9,643,993 Crystalline polymorphic form of ulipristal acetate
A novel crystalline polymorphic form of ulipristal acetate useful as an agent for preventing and/or treating uterine leiomyoma and as a contraceptive, and a...
US-9,643,992 Two crystal forms of ginsenoside C-K and method for preparing same
Provided are ginsenoside C-K polymorphic forms and a method for preparing same. The ginsenoside C-K polymorphic forms are crystal form D and crystal form H.
US-9,643,991 Process for preparing a novel crystalline form of emamectin benzoate and use the same
A crystalline modification V of emamectin benzoate, exhibiting at least 3 of the following reflexes in an X-ray powder diffractogram recorded using Cu--K.alpha....
US-9,643,990 Non-caloric sweeteners and methods for synthesizing
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
US-9,643,989 Methods for preparing ruthenium carbene complex precursors and ruthenium carbene complexes
A method for preparing a ruthenium carbene complex precursor includes reacting a ruthenium refinery salt with a hydrogen halide to form a ruthenium...
US-9,643,988 Compounds having low ionization energy
The present invention provides compounds that are soluble in a non-polar solvent and having a low ionization energy and negative oxidation potentials in...
US-9,643,987 Monophosphites having an unsymmetric biaryl unit
Monophosphites having an unsymmetric biaryl structure and metal complexes thereof are provided. The metal complex compositions are useful as hydroformylation...
US-9,643,986 Factor D inhibitors useful for treating inflammatory disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-9,643,985 PCL compounds, compositions, and methods of use thereof
Disclosed herein are compounds useful for detecting oxidants in a living cell, in a multicellular organism, or in a cell-free sample. In particular, disclosed...
US-9,643,984 Method for the preparation of [1,2,4]-triazolo[4,3-a]pyridines
Disclosed herein are methods for preparing [1,2,4]triazolo[4,3-a]pyridines, particularly ...
US-9,643,983 Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives
A compound of Formula I ##STR00001## in free or salt or solvate form, where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9,...
US-9,643,982 Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein R.sup.1-R.sup.8,...
US-9,643,981 Process for preparing (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,- ...
The present invention relates to the preparation of (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4 ...
US-9,643,980 Benzoxazepin oxazolidinone compounds and methods of use
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: ...
US-9,643,979 Inhibitors of DNA gyrase for the treatment of bacterial infections
The present invention relates to compounds which specifically inhibit bacterial DNA Gyrase and can be used for the treatment of respiratory tract infections.
US-9,643,978 Methods and compounds for synthesizing fused thiophenes
Disclosed herein are thiophene compounds of formulae (I), (I'), (II), (II'), (II''), and (II'''), methods for making such compounds, and methods for making...
US-9,643,977 Necroptosis inhibitors and methods of use therefor
Described herein are compositions that inhibit the production of TNF.alpha. downstream of CD40 activation. As such, also described are various methods of using...
US-9,643,976 Solvates of darunavir
The present invention relates to novel solvates of Darunavir of Formula I. ##STR00001##
US-9,643,975 Synthesis method of 9-allylcamptothecin derivatives
A method for preparing 9-allylcamptothecin derivatives using compound 14 as an essential intermediate. The total yield of the method is high.
US-9,643,974 Amino-substituted imidazopyridazines
The present invention relates to amino-substituted imidazopyndazine compounds of general formula (I): in which A, R1, R2, R3, R4 and n are as defined in the...
US-9,643,973 Crystalline form of diclosulam, a process for its preparation and use of the same
A crystalline form of diclosulam of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods and using the...
US-9,643,972 Immunoregulatory agents
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such...
US-9,643,971 Breathing control modulating compounds, and methods of using same
The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a...
US-9,643,970 Substituted imidazo [1,5-a]pyrazines as PDE9 inhibitors
This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically...
US-9,643,969 (aza)indolizine derivative and pharmaceutical use thereof
(Aza)indolizine derivatives represented by Formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a...
US-9,643,968 Fused acridine derivative and pharmaceutical composition, preparation method and use thereof
Provided is a fused acridine derivative as formula (I), which has good antitumor activity. In addition, also provided are a process for preparing the...
US-9,643,967 Pyrrolo[3,2-c]pyridine derivatives as TLR inhibitors
The present invention provides a heterocyclic compound having a TLR7, TLR9, TLR7/8, TLR7/9 or TLR7/8/9 inhibitory action, which is useful as an agent for the...
US-9,643,966 Compounds for the treatment of cancer and inflammatory diseases
The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various...
US-9,643,965 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
US-9,643,964 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1H-pyrrolo[2,3-C]pyridine derivatives as NIK inhibitors for the...
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
US-9,643,963 Antiparasitic compounds
The invention relates to 1,2,4-thiadiazole derivatives and their use to treat parasites.
US-9,643,962 Processes for preparing dihydropyrimidine derivatives and intermediates thereof
The present invention refers to processes for preparing a dihydropyrimidine compound having Formula (I), or a tautomer thereof having Formula (Ia), as well as a...
US-9,643,961 Cyclohexylamine derivatives having .beta.2 adrenergic antagonist and M3 muscarinic antagonist activities
The present invention relates to novel compounds having .beta.2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions...
US-9,643,960 Procaspase activating compounds
Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis...
US-9,643,959 Tubulin polymerization inhibitor and method for synthesizing same
The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-in- dol-1-yl)acetate as a novel tubulin...
US-9,643,958 Deprotection method for protected hydroxyl group
To deprotect an alcoholic hydroxyl group protected by a t-butyldimethylsilyl group without influencing a functional group unstable to an acid. In the presence...
US-9,643,957 Heterocyclic compounds having cholesterol 24-hydroxylase activity
An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or...
US-9,643,956 Solid forms of an ASK1 inhibitor
Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-y- l)pyridin-2-yl)-2-fluoro-4-methylbenzamide(Compound I) were...
US-9,643,955 2-pyridyloxy-3-nitrile-4-substituted orexin receptor antagonists
The present invention is directed to 2-pyridyloxy-3-nitrile-4-substituted compounds which are antagonists of orexin receptors. The present invention is also...
US-9,643,953 Substituted benzylpyrazoles
Compounds of formula (I) and their use as pharmaceutical. ##STR00001##
US-9,643,952 Pyridone compound
The invention provides a pyridone compound represented by the following formula (I) [wherein, R.sup.1 represents cycloalkyl optionally having substituent(s) and...
US-9,643,951 Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof
The present invention provides a somatostatin receptor subtype 2 agonist. A disclosed compound represented by the general formula (I): ##STR00001## wherein all...
US-9,643,950 Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d.sub.5)-2,6-di- one}
The invention in one embodiment is directed to solid forms of {S-3-(4-Amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d.sub.5)-2,6-di- one}, including an...
US-9,643,949 Method for producing glycolide
A method for producing a GL comprising: (I) a heating step of heating a mixture either under normal pressure or reduced pressure at a temperature at which a...
US-9,643,948 2-oxo-1,3-dioxolane-4-acyl halides, their preparation and use
The present invention suggests 2-oxo-1,3-dioxolane-4-acyl halides of formula (I), ##STR00001## wherein X is selected from F, Cl, Br, I and mixtures thereof,...
US-9,643,947 7-membered fused heterocycles and methods of their synthesis
Disclosed are a new method for synthesizing 7-membered fused heterocycles and compounds synthesized by the new method. The method involves a dual activation...
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