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Patent # Description
US-9,657,114 Electrically chargeable encapsulated particles
Methods of encapsulating particles (260) in polymer (280, 382, 384) and compositions of matter using such encapsulated particles (260). Methods include mixing...
US-9,657,113 Hydrogenation of a diene-based polymer latex
The present invention provides a novel process for selectively hydrogenating the carbon-carbon double bonds in diene-based polymers which are present in latex...
US-9,657,112 Co-agglomerated latex polymer dispersions and methods of preparing and using same
Co-agglomerated dispersions and methods for their preparation are described herein. The co-agglomerated dispersions are prepared by co-agglomerating an anionic...
US-9,657,111 Humanized monoclonal antibodies against activated protein C and uses thereof
Provided are humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Methods of...
US-9,657,110 Polypeptides and use thereof
The present invention provides a polypeptides capable of modulating tissue transglutaminase-induced cell behavior wherein the polypeptide comprises or consists...
US-9,657,109 Compositions and methods for the treatment of systemic inflammatory response syndromes
Described herein are peptides from secretory phospholipase A.sub.2-IB and antibodies that can be used to reduce the contribution of the gastrointestinal tract...
US-9,657,108 Dosage and administration of anti-EGFR therapeutics
Methods for optimizing a therapeutic response in a patient (e.g., a cancer patient) to an anti-EGFR therapy, and methods for preventing or ameliorating infusion...
US-9,657,106 Optimized Fc variants
The present invention relates to Fc variants having decreased affinity for Fc.gamma.RIIb, methods for their generation, Fc polypeptides comprising optimized Fc...
US-9,657,099 Anti-glucagon antibodies
The present invention provides antibodies that bind to glucagon and methods of using the same. According to certain embodiments, the antibodies of the invention...
US-9,657,098 Anti-hepcidin antibodies and uses thereof
The present application relates to antibodies that specifically bind to hepcidin and methods of using the antibodies. Another aspect relates to antibodies which...
US-9,657,096 Human domain antibodies against components of the human insulin-like growth factor (IGF) system
Antibodies and antibody fragments that bind to insulin-like growth factor (IGF) 1 receptor (IGF-1R) or IGF-2, as well as methods of using the antibodies for...
US-9,657,094 Biodegradable polymers for delivery of therapeutic agents
Methods, processes, systems, and compositions for treating disease are disclosed. In some cases, the present disclosure provides for delivery of therapeutic...
US-9,657,093 Methods for treating sepsis using chimeric and humanized anti-histone antibodies
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein....
US-9,657,092 S100A4 antibodies and therapeutic uses thereof
The invention relates to antibodies against S100A4, methods for the preparation of these antibodies, pharmaceutical compositions comprising these antibodies,...
US-9,657,090 Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
The invention provides a method of treating alveolar bone loss involving administration of a sclerostin inhibitor to a subject in need thereof.
US-9,657,087 Subcutaneous administration of anti-hepatitis B antibodies
The present application relates to an immunoglobulin preparation comprising anti-hepatitis B antibodies for subcutaneous administration and to uses thereof,...
US-9,657,086 Whole egg protein peptides, preparation method and use thereof
Provided are whole egg protein peptides and the preparation method thereof, wherein the whole egg protein peptides are obtained by adopting compound proteases...
US-9,657,085 Protease inhibitor: protease sensitive expression system and method improving the therapeutic activity and...
A genetically engineered live bacterium which is adapted to selectively replicate in and colonize a selected tissue type within the mammal, and concurrently...
US-9,657,084 Fusion protein inhibiting angiogenesis or growth and use thereof
Provided are a fusion protein inhibiting angiogenesis or vascular growth, coding sequence thereof, vector comprising the coding sequence, host cell,...
US-9,657,083 Composition comprising a mixture of CD95-Fc isoforms
The present invention relates to a composition comprising a mixture of fusion protein isoforms, each fusion protein comprising an extracellular CD95 domain or a...
US-9,657,082 PD-L1 and PD-L2-based fusion proteins and uses thereof
Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and...
US-9,657,081 Inhibiting peptides derived from triggering receptor expressed on myeloid cells-1 (TREM-1) TREM-like transcript...
The present invention relates to a peptide comprising at least 6 consecutive amino acid selected from the amino acid sequence SEQ ID NO: 2 and a...
US-9,657,079 Truncated GLP-1 derivatives and their therapeutical use
The invention relates to truncated GLP-1 analogs, in particular a GLP-1 analog which is a modified GLP-1(7-35) (SEQ ID No 1) having: i) a total of 2, 3, 4, 5 6,...
US-9,657,074 Enzymatic large-scale synthesis of mucin glyconjugates, and immunogenic applications thereof
The present invention relates to mucin glycoconjugates, and to a process of producing mucin glycoconjugates. It relates to the biological, pharmaceutical and...
US-9,657,073 Inhibitors of Bcl-2
A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids...
US-9,657,072 Modified peptides and their use for treating autoimmune diseases
The present invention relates to a peptide, or a salt thereof, comprising or consisting of the amino acid sequence IHMVYSKRSGKPRGYAFIEY, comprising one or more...
US-9,657,071 IgE peptide vaccine
It is intended to provide an IgE peptide vaccine that can be used in the prevention or treatment of allergic diseases in animals other than mice, such as humans...
US-9,657,069 Anti-cancer compositions containing WNT decoy receptor
The present invention relates to a composition for preventing or treating cancer comprising Wnt decoy receptor. The composition of the present invention or the...
US-9,657,068 Telomerase polypeptide vaccine for treating cancer
A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at...
US-9,657,066 Pseudomonas exotoxin A with less immunogenic B cell epitopes
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more of amino acid residues E420, D463,...
US-9,657,060 Natural IgM antibodies and inhibitors thereof
The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.
US-9,657,058 Compounds for enzyme inhibition
One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain...
US-9,657,056 Integrated continuous manufacturing of therapeutic protein drug substances
Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are...
US-9,657,055 Affinity chromatography matrix
The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains...
US-9,657,054 Immunoglobulin aggregate removal
For the removal of high molecular weight compounds from recombinantly produced polypeptides generally chromatographic methods are employed. It has been found...
US-9,657,052 Compounds and methods of making sterols using diols
Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The...
US-9,657,049 ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors
Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or...
US-9,657,045 Process for producing a particulate composition comprising crystalline trehalose dihydrate
A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an...
US-9,657,044 Method for antagonizing STAT3 dimerization and compounds for use therein
A compound of the formula: ##STR00001## Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient...
US-9,657,038 Guanidine-functionalized particles and methods of making and using
Guanidine-functionalized particles and methods of making and using such particles.
US-9,657,037 Pyrrole compounds with silicon incorporation
The present invention discloses novel Silicon incorporated pyrrole compounds of Formula I having potential anti-bacterial properties. The invention further...
US-9,657,031 Ant-ligands molecules and biological applications
ANT-ligands having a substituted nitrogeneous heterocycle A wherein A is a substituted pyrimidinone of formula I ##STR00001## wherein R1 is ...
US-9,657,028 Processes for making hydrocodone, hydromorphone and their derivatives
Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.
US-9,657,024 Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
Disclosed herein are erythropoietin-mimetic compounds of Formula I, which modulate the survival, function, or differentiation of, for example, kidney cells,...
US-9,657,023 Polymorph of Syk inhibitors
Polymorphs of a bis-mesylate salt of a compound of Formula I: ##STR00001## or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a...
US-9,657,021 Process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2[((3R)-piperidine-3-carbonyl)-hydrazino ...
A process for preparation of (2S,5R)-7-oxo-6-sulphooxy-2-[((3R)-piperidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2.1]octane of Formula (I) is...
US-9,657,017 Crystal form of (R)-praziquantel and preparation method and application thereof
The present invention relates to a crystal form of (R)-praziquantel and a preparation method and uses thereof. The X-ray diffraction pattern (CuK.alpha....
US-9,657,013 Inhibitors of hepatitis B virus covalently closed circular DNA formation and their method of use
Pharmaceutical compositions of the invention comprise covalently closed circular DNA formation inhibitors having a disease-modifying action in the treatment of...
US-9,657,011 Chemical process
The present invention relates to a process for the preparation of umeclidinium bromide, and to processes for preparing intermediates used in the preparation of...
US-9,657,005 Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase...
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit...
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