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Patent # Description
US-9,670,296 Silica-coated alumina activator-supports for metallocene catalyst compositions
Silica-coated alumina activator-supports, and catalyst compositions containing these activator-supports, are disclosed. Methods also are provided for preparing...
US-9,670,295 Block-copolymer containing crosslinkable photoinitator groups
A block-copolymer containing at least two different blocks wherein block A contains (meth)acrylate monomers the copolymer having a glass transition temperature...
US-9,670,294 Method for producing solid catalyst component for use in polymerization of olefin, catalyst for use in...
A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves...
US-9,670,293 Solid single site catalysts with high polymerisation activity
Process for the preparation of a solid catalyst system comprising the steps of preparing a liquid clathrate comprising a mixing of an aluminoxane, an aromatic...
US-9,670,292 Apparatus for producing water-absorbent resin
In an apparatus for producing the water-absorbent resin, gas heated by the polymerization heat accompanied by a polymerization reaction in a reactor main body...
US-9,670,291 Functionalized diene elastomer, and rubber composition containing same
The present invention relates to a specific functionalized diene elastomer. This functionalized elastomer exhibits a reduced cold flow without, however,...
US-9,670,290 Alternan polysaccharide that is functionalized with nitrogen groups that can be protonated, or with permanently...
Functionalized alternan polysaccharide, comprising nitrogen groups or permanently positively charged nitrogen groups that can be protonated as functional groups...
US-9,670,289 Resorbable cellulose based biomaterial and implant
The present disclosure describes an implant for tissue replacement or augmentation including a resorbable non-pyrogenic porous body of irradiated oxidized...
US-9,670,288 Osteoprotegerin in neuroprotection
Methods for treating neurodegeneration, e.g., sensorineural hearing loss, or a demyelinating disease, using bisphosphonates, ERK kinase inhibitors, and...
US-9,670,287 Anti-human TROP-2 antibody having anti-tumor activity in vivo
The present invention provides: an antibody, which specifically reacts with hTROP-2 and has anti-tumor activity in vivo; a hybridoma, which produces the...
US-9,670,286 Disease therapy by inducing immune response to Trop-2 expressing cells
The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for Trop-2 (EGP-1) and at least one...
US-9,670,285 Monoclonal antibody and a method thereof
The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6...
US-9,670,284 Therapeutic uses for VEGFR1 antibodies
The present invention relates to methods of using VEGFR1 antibodies for the treatment of chronic kidney disease.
US-9,670,283 Depletion of plasmacytoid dendritic cells
The present invention relates to antibodies targeted to BDCA2 that deplete plasmacytoid dendritic cells (pDC) and methods of using the antibodies to treat...
US-9,670,282 Compositions and methods for diagnosing and treating an inflammation
A method of treating multiple sclerosis (MS) in a subject in need thereof, the method comprising administering to said subject a therapeutically effective...
US-9,670,281 Binding-triggered transcriptional switches and methods of use thereof
The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the ...
US-9,670,280 Folate receptor 1 antibodies and immunoconjugates and uses thereof
Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using...
US-9,670,279 Folate receptor 1 antibodies and immunoconjugates and uses thereof
Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using...
US-9,670,278 Folate receptor 1 antibodies and immunoconjugates and uses thereof
Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using...
US-9,670,277 Compositions and methods for treating inflammatory conditions of the ocular surface
This application discloses ophthalmic formulations and methods for treating inflammatory disease and conditions of the ocular surface with one or more C--C...
US-9,670,276 IL-1 binding proteins
The disclosure provides binding proteins that specifically bind to IL-1.alpha. and IL-1.beta.. These binding proteins can be organized into DVD-Igs. These...
US-9,670,275 Sequences directed against hepatocyte growth factor (HGF) and polypeptides comprising the same for the...
The present invention relates to biological materials against HGF and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods...
US-9,670,274 Anti-alpha-synuclein antibodies and methods of use
The invention provides anti-human alpha-synuclein antibodies and methods of using the same.
US-9,670,273 Humanized antibodies that recognize alpha-synuclein
The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy...
US-9,670,272 Method of providing disease-specific binding molecules and targets
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes...
US-9,670,271 Production of recombinant proteins with simple glycoforms
The present invention provides cell lines deficient in mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase I (Mgat1). Also provided are...
US-9,670,270 Minicell based delivery of biologically active compounds
Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and...
US-9,670,269 Methods of modifying antibodies for purification of bispecific antibodies
The present inventors devised methods for efficiently purifying bispecific antibodies using a chromatography column based on the difference in isoelectric...
US-9,670,268 Pharmaceutical composition and method of preparing same
An object of the present invention is to provide a pharmaceutical composition comprising an enzyme-treated human serum which is useful for treatment and...
US-9,670,267 Compositions and methods for enhancing coagulation factor VIII function
Factor VIII variants and methods of use thereof are disclosed.
US-9,670,266 Method and composition for crystallizing G protein-coupled receptors
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled...
US-9,670,265 Methods and compositions for modulating toso activity
The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses...
US-9,670,264 Water soluble G-protein coupled receptor
Described herein are recombinant integral membrane proteins having multiple transmembrane domains that have been engineered to be less hydrophobic, through...
US-9,670,263 Modulation of the VPS10p-domain receptor family for the treatment of mental and behavioural disorders
The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin,...
US-9,670,262 Modified SAK gene for the production of recombinant proteins
The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing...
US-9,670,261 Functionalized exendin-4 derivatives
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including...
US-9,670,260 Compositions comprising fusion variants of FGF19 polypeptides
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
US-9,670,259 Method of inhibiting angiogenesis using inhibitors of G-protein-coupled receptor kinase interacting protein-1...
The present invention is directed to methods and compositions comprising G-protein-coupled receptor kinase interacting protein-1 (GIT1) inhibitors that are...
US-9,670,258 Positive modulator of bone morphogenic protein-2
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic...
US-9,670,257 Methods for producing peptides using engineered inteins
The present invention provides a method for producing peptides by recombinant means. The peptides are expressed as part of a fusion protein comprising the...
US-9,670,256 Synthetic active peptide fragments
The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific...
US-9,670,255 Modified biotin, mutant streptavidin, and use thereof
It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin...
US-9,670,254 VMP-like sequences of pathogenic Borrelia species and strains
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to...
US-9,670,253 Antiviral vaccines with improved cellular immunogenicity
The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described...
US-9,670,252 Fusion expression of G-protein coupled receptor
The present invention relates to fusion proteins for the expression of G-protein coupled receptor proteins (GPCR) with the fusion partners, as inserted...
US-9,670,251 ANG-(1-7) derivative oligopeptides and methods for using and producing the same
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment,...
US-9,670,250 Alpha-helical peptidomimetic inhibitors and methods using same
The present invention includes a novel class of highly specific protease inhibitors. In one embodiment, the inhibitors of the invention are .alpha.-helical in...
US-9,670,249 Amphiphilic peptides and hydrogel matrices thereof for bone repair
The present invention relates in general to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in...
US-9,670,248 Method and system for processing of aquatic species
The present disclosure relates, according to some embodiments, to methods for recovering multiple products from industrial-scale production of a biomass of an...
US-9,670,247 Contraceptive agents
The invention provides compounds of formula I, II, III, or IV: ##STR00001## wherein R.sup.1 to R.sup.11, X, and Y have any of the values defined in the...
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