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Patent # Description
US-9,670,246 Process for the esterification of a carbothioic acid
A process for preparing compounds of formula [II] ##STR00001## by esterification of the C-17 hydroxyl group of ...
US-9,670,245 Ginsenoside C-K polymorphic compounds and method for preparing same
Provided are several types of ginsenoside polymorphic substances and a method for preparing same. In particular, new crystal form A, crystal form B, crystal...
US-9,670,244 Oxysterol compounds and the hedgehog pathway
This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof,...
US-9,670,243 Compositions and methods for sequencing nucleic acids
Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme...
US-9,670,242 Tetracyclic anthraquinone derivatives
Disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof, ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
US-9,670,241 Organometallic compound and organic light-emitting device including the same
An organometallic compound represented by Formula 1: M(L.sub.1).sub.n1(L.sub.2).sub.n2 Formula 1 wherein in Formula 1, M, L.sub.1, L.sub.2, n1, and n2 are...
US-9,670,240 Cyclic phosphinate derivatives and method of preparing the same
Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including...
US-9,670,239 Bisphosphites having an outer naphthyl-phenyl unit and a central 2,3'-biphenol unit
Bisphosphites having an outer naphthyl-phenyl unit and a central 2,3'-biphenol unit and their preparation are described.
US-9,670,238 5'-dibenzyl phosphates of 5-azacytidine or 2'-deoxy-5-azacytidine
The present invention relates to a novel compound represented by formula (1), or salt thereof, ##STR00001## wherein R is hydroxy group or hydrogen atom;...
US-9,670,237 Phosphonium-based ionic liquids and their use in the capture of polluting gases
An ionic liquid composition having the following chemical structural formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently...
US-9,670,236 Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from...
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function...
US-9,670,235 Oligomer-foscarnet conjugates
The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a...
US-9,670,234 Metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to...
This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of...
US-9,670,232 Molecular precursor compounds for zinc-group 13 mixed oxide materials
Molecular precursor compounds, processes and compositions for making Zn-Group 13 mixed oxide materials including IZO, GZO, AZO and BZO, by providing inks...
US-9,670,231 Fused tricyclic amide compounds as multiple kinase inhibitors
Provided are fused tricyclic amide compounds, pharmaceutical compositions comprising at least one such fused tricyclic compound, processes for the preparation...
US-9,670,230 Heteroaryl compounds and methods of use thereof
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one...
US-9,670,229 5-HT3 receptor antagonists
The present invention provides 5-HT3 receptor antagonists of Formula (I): ##STR00001## which are useful for the treatment of diseases treatable by inhibition...
US-9,670,228 Benzoxazepin PI3K inhibitor compounds and methods of use
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof,...
US-9,670,227 Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.12, X, A and n are as defined in the...
US-9,670,226 Sesquiterpenoids
The invention provides novel compounds and compositions for inhibiting IKK.alpha./.beta., including treating disorders associated with IKK.alpha./.beta....
US-9,670,225 HIV-1 protease inhibitors and uses thereof
Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or...
US-9,670,223 Compounds with super-aspirin effects
A compound having the structural formula (I) and pharmaceutically acceptable salt and/or hydrates thereof, (I) wherein Y is an arylester or an C.sub.1-C.sub.8...
US-9,670,222 CCR2 receptor antagonists and uses thereof
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and...
US-9,670,221 Furopyridines as bromodomain inhibitors
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
US-9,670,220 Fused heterocyclic derivatives as S1P modulators
The present invention relates to a fused heterocyclic derivative of the formula (I) The variables R1-R4, z, A, Q, X and Y are as defined in the claims. The...
US-9,670,219 Tetrahydrooxepinopyridine compound
[Problem] Provided is a compound having a positive allosteric modulating activity (PAM activity) on an .alpha.7 nicotinic acetylcholine receptor (.alpha.7 nACh...
US-9,670,218 Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of...
US-9,670,217 Process for preparing chlorins and their pharmaceutical uses
The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and...
US-9,670,216 Cannabinoid-2 agonists
The present specification discloses cannabinoid-2 agonists, compositions comprising such cannabinoid-2 agonists, and methods of treating an individual suffering...
US-9,670,215 Compounds useful as inhibitors of ATR kinase
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions...
US-9,670,214 Small molecule myristate inhibitors of Bcr-abl and methods of use
The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group...
US-9,670,213 Pteridine ketone derivative and applications thereof as EGFR, BLK, and FLT3 inhibitor
Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the...
US-9,670,212 Inhibitors of PI3K-delta and methods of their use and manufacture
The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the...
US-9,670,211 Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, W and X are as described herein,...
US-9,670,210 Cyclopropylamines as LSD1 inhibitors
The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
US-9,670,209 Muscarinic agonists
Compounds of formula (I) and methods are provided for the treatment of disease or conditions in which modification of cholinergic, especially muscarinic...
US-9,670,208 Serine/threonine kinase inhibitors
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases....
US-9,670,207 Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein...
US-9,670,206 Pyrido[4,3-B]pyrazine-2-carboxamides as neurogenic agents for the treatment of neurodegenerative disorders
The present invention relates to compounds of general formula I wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein which may be used for the treatment...
US-9,670,205 Toll like receptor modulator compounds
The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical...
US-9,670,204 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
The present invention discloses compounds according to Formula I: ##STR00001## Wherein R.sup.1a, R.sup.1b, R.sup.2, R.sup.4, R.sup.5, R.sup.6a, R.sup.6b,...
US-9,670,203 Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors
Provided are certain fused tricyclic urea compounds and salts thereof, compositions thereof, and methods of use therefor.
US-9,670,202 Substituted triazolopyridines
The present invention relates to substituted triazolopyridine compounds of general formula (I); in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as...
US-9,670,201 Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR.gamma....
US-9,670,200 Quaternary ammonium salt prodrugs
The invention provides a method of sustained delivery of a tertiary amine-containing parent drug comprising administering to a patient an effective amount of a...
US-9,670,199 Ergoline derivatives as dopamine receptor modulators
The invention provides compounds of formula I: ##STR00001## wherein R.sup.1-R.sup.4 have any of the values defined in the specification, and salts thereof....
US-9,670,198 Nicotinic acetylcholine receptor modulators
Provided herein are novel and selective high affinity .alpha.3.beta.4 nicotinic acetycholine receptor ligands and pharmaceutical compositions thereof. In other...
US-9,670,197 Small molecule modifiers of the Hec1-Nek2 interaction in G2/M
Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: ##STR00001## In Formula 1, Z is...
US-9,670,196 Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) (I), or pharmaceutically acceptable salts thereof, wherein ring...
US-9,670,195 Glycosidase inhibitors and uses thereof
The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of...
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