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Patent # Description
US-9,670,194 Substituted aminopyrimidine compounds and methods of use
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form...
US-9,670,192 Substituted isoxazole derivatives
The present invention relates to compounds of the formula I ##STR00001## wherein the substituents are defined in the claims and the specification.
US-9,670,191 Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R.sub.2, R.sub.3, R.sub.4, R.sub.5...
US-9,670,190 Pyridinyl and pyrimidinyl sulfonamide derivatives as chemokine receptor modulators
The present invention relates to novel pyridine or pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their...
US-9,670,189 Substituted condensed pyrimidine compounds
The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) ##STR00001## in which the chemical groupings, substituents...
US-9,670,188 Process for the preparation of crystalline form IV of posaconazole
The present invention relates to an improved large scale process for the preparation of posaconazole form IV.
US-9,670,187 Processes for preparing antiviral compounds
The present disclosure provides processes for the preparation of a compound of formula: ##STR00001## which is useful as an antiviral agent. The disclosure...
US-9,670,186 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula: ##STR00001## where X, R.sup.a, R.sup.b, R.sup.2, and R.sup.7 are as defined in the...
US-9,670,185 Organic electroluminescent materials and devices
Novel carbazole-containing compounds are provided. The novel compounds also contain electron donor groups, aryl linkers, and at least one nitrogen heterocycle....
US-9,670,184 Amorphous allisartan isoproxil, preparation method therefor, and pharmaceutical composition containing...
The present invention relates to an amorphous allisartan isoproxil which is an angiotensin II receptor blocker with good flowability and a large bulk density...
US-9,670,183 Bicyclic AZA compounds as muscarinic M1 receptor and/or M4 receptor agonists
This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4...
US-9,670,182 Method for producing substituted anthranilic acid derivatives
The present invention relates to a process for preparing substituted anthranilic acid derivatives of the formula (I) ##STR00001## in which R.sup.1, R.sup.2,...
US-9,670,181 Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
The invention relates to compounds of the formula ##STR00001## wherein R', R.sub.1 through R.sub.7 and Ar are as defined herein. These compounds are useful as...
US-9,670,180 Certain chemical entities, compositions, and methods
Chemical entities that are quinoxaline kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
US-9,670,179 Antibiotic compositions and methods of use
Embodiments of the present disclosure provide for compositions including an antibiotic containing a N-thiolated beta-lactam moiety, pharmaceutical compositions...
US-9,670,178 Processes for the preparation of pesticidal compounds
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
US-9,670,177 Crystalline C.sub.21H.sub.22Cl.sub.2N.sub.4O.sub.2 malonate
The present invention provides a malonate salt of a compound of formula (I): ##STR00001## which is a crystalline salt. Also provided are pharmaceutical...
US-9,670,176 Process for the preparation of zileuton
The invention discloses a process for the preparation of Zileuton of formula I by employing acetic acid-1-benzo[b]thiophen-2-yl-ethyl-ester of formula-III as an...
US-9,670,175 Protected succinates for enhancing mitochondrial ATP-production
Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile...
US-9,670,174 Mono- and dialkyl ethers of furan-2,5-dimethanol and (tetra-hydrofuran-2,5-diyl)dimethanol and amphiphilic...
Linear mono- and dialkyl ethers of furan-2,5-dimethanol (FDM) and/or 2,5-bis(hydroxymethyl)tetrahydrofuran (bH-MTHF), methods for their preparation, and...
US-9,670,173 Dicarboxylic acid compound
It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. Solution: A compound represented by a general...
US-9,670,172 Heterocyclic compounds and methods of use
This disclosure provides compounds and methods of using those compounds to treat metabolic disorders and hyperproliferative disorders, including administration...
US-9,670,171 Process for preparing fluoxastrobin
A process for preparing (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (13) or ...
US-9,670,170 Resorufin derivatives for treatment of oxidative stress disorders
Disclosed herein are resorufin derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including...
US-9,670,169 Process for the preparation of Efavirenz using keton solvents
An improved process for the preparation of Efavirenz which avoids the distillations of the solvents is provided.
US-9,670,168 Facile method for preparation of 5-nitrotetrazolates using a flow system
Described are methods for preparing salts of 5-nitrotetrazolate that include reacting aqueous solutions of 5-aminotetrazole, an acid, and sodium nitrite in a...
US-9,670,167 Reactive UV absorber, making method, coating composition, and coated article
Novel UV absorbers of benzotriazine type having a plurality of (meth)acryloxy groups have a UV absorbing capacity and a high solubility in multifunctional...
US-9,670,166 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 ##STR00001## and their use as inhibitors of neutrophil elastase activity,...
US-9,670,165 SIK inhibitor for use in a method of treating an inflammatory and/or immune disorder
The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are...
US-9,670,164 Processes for the preparation of pesticidal compounds
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
US-9,670,163 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide
The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide (Compound 1),...
US-9,670,162 Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof
The present disclosure provides compounds of formula (I) that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of...
US-9,670,161 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group of general formula (I) as described and defined...
US-9,670,160 Process for the preparation of tofacitinib and intermediates thereof
The present invention relates to process for the preparation of tofacitinib and intermediates thereof.
US-9,670,159 Pharmaceutical composition of a papillomavirus inhibitor
The invention relates to a pharmaceutical composition including a compound of general formula (I) combined with a solvent and a viscosity-enhancing agent, as...
US-9,670,158 Amorphous tecovirimat preparation
Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-et- ...
US-9,670,157 Benzylamine derivatives
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
US-9,670,156 Crystal form III of (S)-oxiracetam, preparation method and use thereof
(S)-4-hydroxy-2-oxo-1-pyrrolidine crystal form III (called crystal form III of (S) -oxiracetam for short) has diffraction peaks at diffraction angles 2.theta.,...
US-9,670,155 Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
The present invention relates to a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrro- lidin-3-one...
US-9,670,154 Amido compounds and their use as pharmaceuticals
The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and...
US-9,670,153 Compositions and methods for the treatment of inflammation and lipid disorders
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers,...
US-9,670,152 Ionizable cationic lipid for RNA delivery
What is described is a compound of formula I ##STR00001## wherein R is a linear alkyl of 1 to 12 carbons, or a linear alkenyl or alkynyl of 2 to 12 carbons;...
US-9,670,151 Tetralin and indane derivatives and uses thereof
Compounds of the formula I: ##STR00001## or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R.sup.1 and R.sup.2 are as defined herein. Also...
US-9,670,150 (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators
The present invention relates to (2-ureidoacetamido)alkyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use...
US-9,670,149 Process for preparing guanidino-functional monomers
A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one...
US-9,670,148 Method for producing meta-xylylenediisocyanates
A method for producing meta-xylylenediisocyanates includes a reaction step in which monohalogenated benzenes, formaldehydes, and an amide compound represented...
US-9,670,146 On-line analysis of acrylonitrile product
An apparatus comprises a first controller configured to control at least the flow rate of a polymerization inhibitor or acrylonitrile product to a first...
US-9,670,145 Process for preparing 1,1-disubstituted ethylene monomers
The present invention relates to a process for preparing 1,1-disubstituted ethylene monomers having general formula (I) from a compound of general formula (II)...
US-9,670,144 Process for the preparation of 2-cyano-3,3-diarylacrylates
The present invention relates to a novel process for preparation of 2-Cyano-3,3-diarylacrylates by the Knoevenagel condensation of Cyanoacetic esters and...
US-9,670,143 (2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydro- xmethyl-2-methylpentanoic acid
In one aspect, the invention relates to a compound of the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, and a crystalline form of this...
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