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Patent # Description
US-9,688,778 Thermally modified starch
A process for producing thermally inhibited starch is described resulting in a visco-stable starch product with improved whiteness. The process comprises...
US-9,688,777 Protein-polymer complex, TGase substrate-containing polymer, TGase substrate-containing monomer, method for...
Provided is a protein-polymer complex which is capable of detecting a target with good sensitivity. Specifically provided is a protein-polymer complex...
US-9,688,776 Anti-human mIgA antibodies capable of lysing mIgA-B lymphocytes and decreasing IgA production
Disclosed herein is an anti-migis-.alpha..alpha.antibody specific for the migis-.alpha. of human m.alpha. chain that can bind to mIgA on B lymphocytes, cause...
US-9,688,774 Anti c-Met antibodies
The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth...
US-9,688,772 Anti-GD2 antibodies
In this application are described chimeric, humanized, affinity matured, stability enhanced, and bispecific Anti-GD2 antibodies and fragments thereof. Also...
US-9,688,770 Anti-CD98 antibody processes
A human antibody or a functional fragment thereof having specific binding ability to CD98 which is derived from the cell membrane of cancer cells and is in the...
US-9,688,767 Method of predicting survival time in myocardial infarction patients by measuring BAFF levels
The present invention relates to a method for predicting the survival time of a patient suffering from myocardial infarction or the recurrence of a myocardial...
US-9,688,762 Modified antibody constant region
The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated...
US-9,688,760 Anti-leukocyte adhesion for the mitigation of potential adverse events caused by CD3-specific binding domains
The present invention relates in essence to use of a compound, which decreases or inhibits the binding of mammalian T-cells to mammalian endothelial cells for...
US-9,688,759 Ferroportin antibodies and methods of use
Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies,...
US-9,688,758 Single-chain antibodies and other heteromultimers
The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying...
US-9,688,757 Bi-specific affinity reagents for cell-lineage-specific TNF-alpha neutralization
The invention relates to isolated bispecific affinity reagents, such as antibodies or antibody fragments that bind TNF.alpha. and a marker molecule for...
US-9,688,756 Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor
Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher...
US-9,688,754 Anti-ACTH antibodies and use thereof
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the...
US-9,688,753 Nucleic acids encoding antibodies that bind IL-23
The present invention provides an antibody that binds to the p19 subunit of human IL-23 and is characterized as having high affinity, selective, and...
US-9,688,752 Low acidic species compositions and methods for producing and using the same using displacement chromatography
The present invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods...
US-9,688,750 Anti-nodal antibodies and methods of using same
The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or...
US-9,688,742 Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (IBD) and...
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention...
US-9,688,741 Elastic hydrogel
The present invention relates to hydrogels and to the use of hydrogels for repair or restoration of tissue. In particular, the hydrogels of the present...
US-9,688,738 Immunotherapy against ErbB-3 receptor
The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More...
US-9,688,729 Respiratory syncytial virus (RSV) vaccine
The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory...
US-9,688,725 Bacillus sp. biosurfactants, composition including same, method for obtaining same, and use thereof
Biosurfactants produced by a strain of Bacillus sp and to uses thereof. A composition comprising the biosurfactants, and a method for producing the ...
US-9,688,723 C4S proteoglycan specific transporter molecules
The present invention relates to isolated molecules, peptides, and polypeptides of specific consensus sequences or structures, and to compounds comprising or...
US-9,688,717 Raman tag
The present invention provides novel Raman tags for exploring membrane interactions in cells. The tags comprise a phenyl diyne probe where in the dyine is...
US-9,688,710 Inhibitors of sodium glucose cotransporter 1
Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes...
US-9,688,707 Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
The present invention provides bicyclic morpholino compounds and oligomeric compounds prepared therefrom. More particularly, incorporation of one or more of the...
US-9,688,705 Methods for synthesizing metal mesoporphyrins
Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin...
US-9,688,702 Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
The present invention provides compounds of Formula (I) as inhibitors of LMP7 for the treatment of autoimmune and inflammatory diseases. ##STR00001##
US-9,688,699 3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines
The present application relates to novel 3-(pyrimidin-2-yl)imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in...
US-9,688,698 Heteroaromatic compounds and their use as dopamine D1 ligands
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
US-9,688,691 Macrocyclic quinazole derivatives and their use as MTKI
The present invention concerns the compounds of formula ##STR00001## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically...
US-9,688,687 Polymorphic forms of icotinib phosphate and uses thereof
Disclosed is Icotinib phosphate (i.e., the compound of Formula (I)) and polymorph forms thereof, and methods of preparing and using them. ##STR00001##
US-9,688,684 Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
The present invention relates to tetrahydro-tetrazolo[1,5-a]pyrazine compounds of formula (I), wherein R.sup.1 denotes --R.sup.3, --CH.sub.2--R.sup.3 or...
US-9,688,683 Substituted condensed pyrimidine compounds
Novel substituted condensed pyrimidine compounds of general formula (I) ##STR00001## in which the chemical groupings, substituents and indices are as defined...
US-9,688,680 Compositions useful for treating disorders related to kit
Compounds and compositions useful for treating disorders related to Kit are described herein.
US-9,688,670 Benzimidazole compounds and medical uses thereof
The present invention provides a medicament for treating a disease involving Nav 1.7 such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber...
US-9,688,669 Oxazolidinones as modulators of mGluR5
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are...
US-9,688,668 Long chain base sphingosine kinase inhibitors
The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of...
US-9,688,664 Modulators of fatty acid amide hydrolase
4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. ...
US-9,688,658 Process for the optical purification of esomeprazole
An efficient process for increasing the optical purity of the active pharmaceutical ingredient Esomeprazole, by means of a substantially quantitative and...
US-9,688,654 Compounds inhibiting leucine-rich repeat kinase enzyme activity
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in...
US-9,688,652 Hydrogenation of catmint oil
Disclosed are methods for treating catmint oil. The process allows the separation of sulfur-containing compounds from the catmint oil. The treated catmint oil...
US-9,688,651 Geranyl geranyl acetone analogs and uses thereof
The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the...
US-9,688,650 Method for producing 2-substituted 4-hydroxy-4-methyl-tetrahydropyrans in a reactor cascade
The invention relates to a method for producing 2-substituted 4-hydroxy-4-methyltetrahydropyrans.
US-9,688,649 Amide-linked perfluoropolyether thiol compounds and processes for their preparation and use
A perfluoropolyether thiol compound comprises a perfluoropolyether segment, at least one mercapto group (--SH), and at least one intervening divalent...
US-9,688,648 Process for the preparation of propylene oxide
A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile,...
US-9,688,647 Alkylene oxide synthesis
Direct epoxidation of propene is carried out on electrochemically tuned mixed oxide catalyst surfaces in a single chamber reactor with mixed reaction gas of...
US-9,688,646 Process for producing N-methyl or N,N-dimethyl amines
A process for producing N-methyl or N,N-dimethyl amines, which comprises using amine compound, nitro-containing compound or nitrile compound as a starting...
US-9,688,645 Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa
The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula...
US-9,688,644 Synthesis of Tetracyclines and intermediates thereto
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the...
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