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Patent # Description
US-9,717,736 Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors
There is provided a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture...
US-9,717,735 Tricyclic lactams for use in HSPC-sparing treatments for RB-positive abnormal cellular proliferation
This invention is in the area of tricyclic lactam compounds for and methods of treating selected Rb-positive cancers and other Rb-positive abnormal cellular...
US-9,717,734 Chewable lipid supplements containing caffeine for increasing alertness, focus and energy
Flavored chewable wafers containing caffeine suitable for increasing alertness and allow an individual to perform tasks in a more focused and energetic manner...
US-9,717,733 Edible plant-derived microvesicle compositions including conjugated therapeutic agents and methods for using...
A composition is provided that includes a microvesicle derived from an edible plant and a therapeutic agent conjugated to the microvesicle. The therapeutic...
US-9,717,732 Drug combination
The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is ...
US-9,717,731 TEC family kinase inhibitor adjuvant therapy
Described herein are methods and compositions comprising a covalent TEC family kinase inhibitor for use in adjuvant therapy, including adjuvant cancer therapy,...
US-9,717,730 Combinations of AKT inhibitor compounds and chemotherapeutic agents, and methods of use
The invention provides combinations comprising a) compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof wherein R.sup.1, R.sup.2,...
US-9,717,729 Fluorinated integrin antagonists
The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to...
US-9,717,728 Pharmaceutical combination comprising a B-Raf inhibitor and a histone deacetylase inhibitor and their use in...
A pharmaceutical combination comprising (a) a B-Raf inhibitor and (b) a histone deacetylase inhibitor; the uses of such combination in the treatment of...
US-9,717,727 Methods of treating and preventing leukemia and other cancers of the blood and bone
The present invention relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by inhibiting...
US-9,717,726 Product and method for treating diarrhea
A method of treating diarrhea in a patient includes administering an H1 receptor antagonist and an H2 receptor antagonist to the patient.
US-9,717,725 Use of opioid antagonists
Embodiments of the invention provide methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell...
US-9,717,724 Methods for treating pancreatic cancer using combination therapies
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional...
US-9,717,723 Liposomes useful for drug delivery
The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging...
US-9,717,722 Methods and agents for treating tyrosinase-positive albinism
Methods for treating a subject with tyrosinase-positive albinism; agents and compositions thereof for use in treating tyrosinase-positive albinism; and...
US-9,717,721 Use of aryl-quinolin derivatives as inhibitors of vasculogenic mimicry
Aryl-quinolin derivatives for use in inhibiting vasculogenic mimicry, treating diseases characterized by abnormal vascular morphology or function and/or by the...
US-9,717,720 Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof...
US-9,717,719 Treatment, prevention, and reversal of alcohol-induced liver disease
This invention relates to methods for treating, preventing, or reversing liver disease or damage produced by chronic alcohol intake by administering at least...
US-9,717,718 Anti-inflammatory compounds
Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as...
US-9,717,717 Methods of treating cancer through the inhibition of USP7 and immune system modulation
Methods and compounds for treating cancer by, for example, modulating immune system activity, are provided.
US-9,717,716 Methods of sedation during critical care treatment
Methods of sedating a patient undergoing critical care treatment using intravenous gaboxadol are provided.
US-9,717,715 Method of combination therapy using an anti-C-Met antibody
A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at...
US-9,717,714 Spirocyclic CETP inhibitors
Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising...
US-9,717,713 Benzimidazole derivatives: preparation and pharmaceutical applications
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to...
US-9,717,712 Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function...
US-9,717,711 Methods and compositions for treating Clostridium difficile associated disease
The present invention provides methods for treating and preventing the reoccurrence of C. diff infection by administering an immunoglobulin concentrate in...
US-9,717,710 Treatment of mild and moderate Alzheimer's disease
The present invention relates to methods of treatment using [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)- -propyl]-diethyl amine...
US-9,717,709 Substituted pyrazoles as heat shock transcription factor activators
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically...
US-9,717,708 Process for preparing ertapenem-containing lyophilized formulation
The present invention provides a process for preparing an ertapenem-containing lyophilized formulation, comprising the use of hydroxypropyl .beta.-cyclodextrin...
US-9,717,707 Pharmaceutical statin composition
The invention relates to a pharmaceutical composition, comprising or consisting of: 10 to 30 weight percent of at least a pharmaceutically active amount of a...
US-9,717,706 Chromone inhibitors of S-nitrosoglutathione reductase
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and...
US-9,717,705 Anaplerotic therapy of huntington disease and other polyglutamine diseases
The present invention relates to a method for treating and/or preventing Huntington disease and other polyglutamine diseases, comprising the step of...
US-9,717,704 Method of treating, delaying and/or preventing Alzheimer's Disease
The present invention relates to the treatment and/or prevention of Alzheimer's Disease or the symptoms associated therewith by daily administration of a drink...
US-9,717,703 Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed
Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed.
US-9,717,702 Treatment of cancer with specific RXR agonists
A method of treating cancer is disclosed comprising administering to a patient in need of such treatment a RXR agonist at a level below the RAR activating...
US-9,717,701 Compositions for overcoming resistance to tramadol
Disclosed herein is a composition for oral administration of O-desmethyltramadol that is effective for overcoming resistance to tramadol in patients.
US-9,717,700 Methods for overcoming resistance to tramadol
There is disclosed a method for treating disorders modulated by at least opiate receptor activity or monoamine activity, including acute and chronic pain,...
US-9,717,699 Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides
Sterilized wound healing compositions comprise stabilized cyanoacrylate monomers homogenously mixed together with a naphthoquinone 2,3-oxide, including vitamin...
US-9,717,698 Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy
A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin...
US-9,717,697 Compositions and methods for the transdermal delivery of methylphenidate
Compositions for the transdermal delivery of methylphenidate in a flexible, finite form are described. The compositions comprise a polymer matrix that includes...
US-9,717,696 Enteric coated multiparticulate composition with proteinaceous coating for improved storage stability
A storage stable L-menthol composition includes a tablet, caplet, capsule, or sachet dosage form. The dosage form has (a) a plurality of individual cores...
US-9,717,695 Constructs for diagnosing and treating inflammatory bowel diseases and colon cancer
The present invention features, inter alia, constructs for the delivery of therapeutic and diagnostic agents to a patient. The constructs can include a...
US-9,717,694 Peptide/particle delivery systems
Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use...
US-9,717,693 Compositions of microparticles and granules for oral controlled release of substances for veterinary use
Microparticles or granules intended for use in the zootechnical field, constituted by a core which contains a substance having a pharmacological action, a food...
US-9,717,692 Effervescent formulations comprising dexketoprofen
The present invention relates to water-soluble formulations comprising the active agent dexketoprofen and to a process for production of said formulations. The...
US-9,717,691 Pharmaceutical containing a hormone combination having a contraceptive effect and an insulin sensitizer
The present invention relates to a medicament in the form of daily units, which contain an active ingredient combination consisting of a hormone combination...
US-9,717,690 Cleavable lipids
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are...
US-9,717,689 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate...
US-9,717,688 Controlled release of biological entities
A process is provided for releasably encapsulating a biological entity. The process comprises combining a solution of a surfactant in a non-polar solvent with a...
US-9,717,687 Lipid membrane structure including bacterial cell component having dispersibility in non-polar solvent, and...
[Problem] To provide: a lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration, contains...
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