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Patent # Description
US-9,732,161 Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods...
Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for...
US-9,732,160 Methods of treating acute myeloid leukemia with antibodies to bone marrow stromal antigen 1
The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and...
US-9,732,158 Antibodies against fatty acid synthase
The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized...
US-9,732,157 Methods for the development of metzincin-selective catalytic cleft directed antibodies for therapeutic and...
In some aspects, general methods to develop highly selective inhibitory antibodies towards members of the metzincin superfamily of metalloproteases and their...
US-9,732,156 Methods of treating rheumatoid arthritis using antibodies to matrix metalloproteinase 9
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to...
US-9,732,155 Crystal structures of heterodimeric Fc domains
Disclosed are the atomic coordinates of compositions comprising Fc heterodimer proteins in crystalline form derived from high resolution x-ray diffraction....
US-9,732,154 Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
The present invention relates to combination therapies with anti-CD38 antibodies.
US-9,732,153 Antibodies directed against signal peptides, methods and uses thereof
Provided are methods employing antibodies directed against the signal peptide (SP) domain of various disease-associated polypeptides. These anti-SP antibodies...
US-9,732,152 Formulation of human antibodies for treating TNF-alpha associated disorders
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
US-9,732,151 Biomarkers for TSLP treatment
The present invention relates to biomarker responsive to treatment with an anti-Thymic Stromal Lymphopoietin (TSLP) antibody.
US-9,732,150 Therapeutic use of antibodies to HGF
The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in...
US-9,732,149 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial...
US-9,732,148 Anti-.alpha.-synuclein antibodies and methods of use
The present invention relates to anti-alpha-synuclein (anti-.alpha.-synuclein) antibodies and methods of using the same.
US-9,732,147 Method for delivering alpha-melanocyte stimulating hormone mimetibody composition comprising propylene glycol...
Pharmaceutical compositions and methods for delivering a polypeptide to the central nervous system of a mammal via intranasal administration are provided. The...
US-9,732,146 Antibody-mediated transduction of heat shock proteins into living cells
The invention provides for a fusion protein comprising a 3E10 Fv joined to a Hsp-70, Hsp-27, Hsp-90 or GRP-78 or portion thereof, and optionally, the 3E10 Fv...
US-9,732,145 Antibodies directed to Bacillus anthracis protective antigen
This disclosure generally relates to therapeutic antibodies for treating Bacillus anthracis (B. anthracis) infection, to specific variants thereof,...
US-9,732,144 Infectious bursal disease (IBDV) vaccine compositions
Provided herein are methods and compositions relating to Infectious Bursal Disease Virus (IBDV), and vaccines for treatment and prevention thereof.
US-9,732,143 Methods and materials for enhancing functional protein expression in bacteria
Novel materials and methods useful for expressing heterologous proteins in prokaryotic cells are provided, including prokaryotic cells expressing FkpA and/or Skp.
US-9,732,142 Intracellular antibody delivery
The present invention concerns a composition comprising vesicles and encapsulated within the vesicles, an antibody, wherein the vesicles comprise an amphiphilic...
US-9,732,141 Therapeutically useful molecules
A T cell receptor molecule (TCR) containing an alpha chain portion and a beta chain portion wherein the alpha chain portion contains three complementarity...
US-9,732,140 Use of soluble forms of CD83 and nucleic acids encoding them for the treatment or prevention of diseases
The present invention provides for the use of soluble forms of CD83 and nucleic acids encoding them for the treatment of diseases caused by the dysfunction or...
US-9,732,139 Methods of treating cancer by administering a soluble receptor comprising a human Fc domain and the Fri domain...
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means...
US-9,732,138 Loss of function mutations in KCNJ10 cause SeSAME, a human syndrome with sensory, neurological, and renal deficits
The invention includes a method of identifying a human subject at-risk of developing SeSAME syndrome. The invention also includes a method of diagnosing a human...
US-9,732,137 Semi-recombinant preparation of GLP-1 analogues
A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of...
US-9,732,136 VIP fragments and methods of use
The invention relates to composition comprising a pharmaceutically effective amount of one or more functional vasoactive intestinal peptide (VIP) fragments, and...
US-9,732,135 Targeting of human interferon antagonists
The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule....
US-9,732,134 Method of treating graft versus host disease using IL-2 muteins
Described herein are immunosuppressive molecules including immunosuppressive variants of IL-2, and use of such molecules to treat inflammatory and autoimmune...
US-9,732,133 Therapeutic IL-13 polypeptides
Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13R.alpha.2, relative...
US-9,732,132 Therapeutic compositions and methods for disorders associated with neuronal degeneration
Disclosed are isolated mutant erythropoietin (EPO) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such...
US-9,732,131 Identification and use of novopeptides for the treatment of cancer
Compositions, methods, systems, apparatus and/or articles of manufacture are disclosed for reducing the susceptibility of a population and/or members thereof to...
US-9,732,130 WNT7A compositions and method of using the same
There are provided compositions and methods for modulating stem cell division, in particular, division symmetry. It has been demonstrated that Wnt7a polypeptide...
US-9,732,129 Peptides and uses thereof
Disclosed herein are zinc finger peptides having at least 4 zinc finger domains, such as 6, 11, 12 or 18 zinc finger domains. The zinc finger peptides may be...
US-9,732,128 Methods of modifying transcriptional regulatory networks in stem cells
The vast differentiation potential of human embryonic and induced pluripotent stem cells, including their potential to cascade through all of the somatic cell...
US-9,732,127 Colorimetric and fluorescent proteins
The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a...
US-9,732,126 Method for crystallization of TRX-TXNIP complex mutein and 3D structure thereof
The present invention relates to a modified TXNIP protein, a method for preparing the modified TXNIP protein, a polynucleotide encoding the modified protein, an...
US-9,732,125 Polypeptide particle and method for producing same
Polypeptide particles of the present invention are particles of a polypeptide derived from spider silk proteins, and have an average particle size of 1000 nm or...
US-9,732,124 Peptides and compositions for prevention of cell adhesion and methods of using same
Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2),...
US-9,732,123 Mono or multivalent botulinum neurotoxin based vaccine using the heavy chain from serotypes of Clostridium...
Disclosed herein are compositions and methods for treating Clostridium botulinum neurotoxin intoxication and in particular, vaccines against the neurotoxin that...
US-9,732,122 Attenuated recombinant vesicular stomatitis viruses comprising modified matrix proteins
The present invention relates to vesicular stomatitis virus (VSV) matrix (M) protein mutants. One mutant M protein includes a glycine changed to a glutamic acid...
US-9,732,121 Rational vaccine design for hepatitis C virus
Compositions and methods are provided relating to HCV E2 protein and modifications thereto which enhance the immunogenicity of the protein for vaccine...
US-9,732,120 Self-assembled peptide nanostructures by exploiting conformational change, biosensor using the same and...
The present disclosure relates to a self-assembled peptide nanostructure including at least one amphiphilic peptide and a biosensor using the same. The...
US-9,732,119 Immunomodulators
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
US-9,732,118 Modulation of antigen immunogenicity by deleting epitopes recognized by NKT cells
The invention describes a method and compounds for the prevention of immune responses towards allofactors, towards viral vectors used for gene therapy and gene...
US-9,732,117 Steroids as agonists for FXR
The invention relates to compounds of formula (I): ##STR00001## wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino...
US-9,732,116 Preparation and uses of obeticholic acid
The present invention relates to obeticholic acid: ##STR00001## or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic...
US-9,732,115 3-(4'-substituted)-benzyl-ether derivatives of pregnenolone
The invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein R1 is C1-8 alkyl, C1-8 alkoxy, CN, NO.sub.2, amino,...
US-9,732,114 Compounds having anti-adhesive effects on cancer cells
Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3'.fwdarw.P5' thiophosphoramidate (NPS) internucleoside linkages,...
US-9,732,113 Dendrimeric dye-containing oligonucleotide probes and methods of preparation and uses thereof
The invention provides novel oligonucleotide probes that have dendrimeric dyes useful for detecting and analyzing biological samples, and compositions and...
US-9,732,112 Synthesis of 2',3'-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization
Methods for preparation of 2',3'-dideoxynucleotides support structures, such as 2',3'-dideoxyguanosine, 2',3'-dideoxyadenosine, and 3'-deoxythymidine support...
US-9,732,111 2'-alkynyl substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
The present invention relates to 2'-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1,...
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